HLA-DRB3

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HLA-DRB3

Official Full Name HLA-DRB3 major histocompatibility complex, class II, DR beta 3 [ Homo sapiens ]
Background HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Synonyms major histocompatibility complex, class II, DR beta 3; 4951; MGC117330; DR7; MHC class II antigen DRB3; human leucocyte antigen DRB3; MHC class II HLA-DR beta 3 chain; MHC class II antigen DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA-DR3B
    • Species :
    • Human
    • Source :
    • E.coli
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DRB3-1210H Recombinant Human HLA-DRB3, GST-tagged Wheat Germ GST
    Human HLA-DRB3-13823H Recombinant Human HLA-DRB3, His-tagged E.coli His
    Human HLA-DRB3-798HCL Recombinant Human HLA-DRB3 cell lysate N/A

    HLA-DRB3 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB3 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome MHC2DCB; ITGA2; TLR4BB; ATP6V1AA; ATP6V1BA; TUBB6; DYNC1I2A; ATP6V0E; ATP6V1C2; MPO
    Cell adhesion molecules (CAMs) CLDNE; OCLN; NRXN2; ICOS; ITGB2L; CDH2; HLA-C; CADM1A; PVRL1B; ITGA8
    Antigen processing and presentation HSP90AB1; KLRC2; HLA-DPA1; CTSB; HSPA1B; IFNG; HLA-DMA; KIR2DL3; KLRD1; HLA-A
    Hematopoietic cell lineage CD7; ITGA4; HLA-DRA; IL11RA2; IL1R2; CSF1R; HLA-DRB3; EPO; CD1A; IL11
    Intestinal i LTBR; H2-AB1; HLA-DMA; BMA1; TNFRSF17; HLA-DPA1; CXCL12A; CXCL12; ICOSLG; HLA-DRB5
    ne network for IgA production TGFB1; IL15; TNFRSF17; PIGR; CXCL12A; CCR10; ITGA4; MADCAM1; CCL28; IL15RA
    Type I diabetes mellitus HLA-DRA; CPE; PRF1; HLA-A; HLA-DRB5; IL1A; HLA-DOA; HLA-DPB1; INS2; Fasl
    Leishmaniasis STAT1; Itgam&Itgb2; TNF; FOS; HLA-DQA1; HLA-DMA; IRAK4; TGFB1; FCGR2A; HLA-DOB
    Toxoplasmosis H2-AB1; Toxoplasma Gondii Major Surface Antigen P30; HSPA2; GNAI1; PIK3CD; TGFB3; BIRC8; MAPK3; IFNGR2; Toxoplasma Gondii Microneme Protein MIC3
    Staphylococcus aureus infection FGG; ITGAM; C1QB; C1S; C5; HLA-DMB; FCAR; HLA-DMA; FCGR1; FCGR3
    Tuberculosis IFNA5; RHOA; IFNA16; ITGB2L; ITGAM; HSPA9; RIPK2; KSR1; HLA-DOB; VDR
    Influenza A OAS2; IL12A; HLA-DRA; TRIM25; NLRP3; OAS3; MAPK11; FAS; PIK3CB; HLA-DQB1
    HTLV-I infection H2-AB1; PPP3CA; VDAC3; FZD7; MAP3K14; WNT3; POLE2; TRP53INP1; IL2RG; GPS2
    Herpes simplex infection TBPL1; JAK2B; NFKBIB; CDK1; TRAF2; ARNTL1A; TAF13; SRSF7; C3A.1; BMA2
    Epstein-Barr virus infection HLA-DQA2; RAN; FCER2; IRF3; MAPK13; HLA-G; TRAF2; CSNK2B; HSPA1L; TRAF6
    Asthma MS4A2; CD40; HLA-DRB1; H2-AB1; H2-AA; HLA-DOB; IL3; PRG2; EPX; FCER1G
    Autoi Il2; IFNA6; IFNA8; CD28; IFNA5; HLA-DPB1; H2-AA; IFNA16; Ifna11; IFNA13
    ne thyroid disease HLA-DOA; HLA-DQA1; IL5; HLA-DRB5; IFNA21; CD86; Fasl; IFNA17; HLA-DRB1; Ifna11
    Inflammatory bowel disease (IBD) HLA-DPA1; HLA-DRB5; TGFB2; Il23a; Il12b; IL21R; IL1B; Il23a; IL18; IL18R1; SMAD3
    Systemic lupus erythematosus HIST2H4A; FCGR3A; HIST3H3; GM14476; HIST1H2AI; HIST2H3C1; CD40LG; C1QB; HIST1H4H; GM14477
    Rheumatoid arthritis IL17A; ATP6V0D2; H2-AB1; FOS; LTB; Ctsl; ATP6V1G1; HLA-DRA; TNFSF13B; Ccl12
    Allograft rejection H2-Q10; CD40LG; Il2; FASLG; HLA-B; Fasl; HLA-DMB; IL12A; HLA-C; HLA-DQB1
    Graft-versus-host disease HLA-DOA; HLA-DPB1; IL1A; KIR2DL1; HLA-F; Il2; HLA-B; Fasl; FAS; CD86
    Viral myocarditis HLA-F; HLA-G; BID; CYCS; CASP8; ITGB2; Casp3; FYN; HLA-DRB5; SGCA

    HLA-DRB3 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB3 itself. We selected most functions HLA-DRB3 had, and list some proteins which have the same functions with HLA-DRB3. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DOA; HLA-DQB1; HLA-DRA; HLA-DRB4; HLA-DRB1; KRT17; HLA-DQA2; HLA-DQB2; HLA-DPA1; HLA-DRB3
    peptide antigen binding HLA-G; MHC1ZHA; AZGP1; BF2; HLA-DPA1; CLEC4M; H2-Q10; MHC1UIA; HLA-DPB1; MHC1ZBA
    protein binding RIBC1; TRPC4AP; EGLN2; HGD; SMARCA5; PVR; UBTD1; AGAP2; TBC1D16; KCTD17

    HLA-DRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB3.

    MAP3K13; CDCA8; ZDHHC17

    Kosmoliaptsis, V; Gjorgjimajkoska, O; et al. Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation. KIDNEY INTERNATIONAL 86:1039-1048(2014).
    Baxter-Lowe, LA; Cecka, M; et al. Center-Defined Unacceptable HLA Antigens Facilitate Transplants for Sensitized Patients in a Multi-Center Kidney Exchange Program. AMERICAN JOURNAL OF TRANSPLANTATION 14:1592-1598(2014).

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