HLA-DRB4 Protein


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Official Full Name major histocompatibility complex, class II, DR beta 4
Background HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Synonyms HLA-DRB4; major histocompatibility complex, class II, DR beta 4; HLA DR4B; DR4; DR-4; leukocyte antigen; MHC class2 antigen; MHC HLA DR-beta chain; MHC class II antigen DRB4; DRB1 transplantation antigen; human leucocyte antigen DRB4; MHC class II antigen
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DRB4-3738H Recombinant Human HLA-DRB4 protein, GST-tagged E.coli GST
    Human HLA-DRB4-1209H Recombinant Human HLA-DRB4, GST-tagged Wheat Germ GST
    Human HLA-DRB4-2263H Recombinant Human HLA-DRB4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-DRB4-5492HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DRB4 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB4 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CLDN5A; CNTNAP1; TIGIT; BF2; CLDN11A; HLA-C; NRXN2A; CLDN17; HLA-F; NCAM1A
    Antigen processing and presentation HLA-A; HLA-DOB; CANX; TAPBP; HLA-DRB4; KLRC4; CTSS; KIR3DL1; HSPA5; CD4
    Hematopoietic cell lineage CD22; GP1BA; Kitl; IL1R1; IL1A; FLT3LG; CSF1R; CD5; GM2002; CD1D2
    Intestinal i CCR9A; BMA1; HLA-DRA; HLA-DPB1; ITGA4; CD86; BLB2; MHC2DAB; CXCL12A; CD28
    ne network for IgA production HLA-DQB1; LTBR; TNFSF13; BMA2; HLA-DRA; TGFB1A; HLA-DRB3; CXCR4; CCL28; CD40LG
    Type I diabetes mellitus INS2; HLA-DRB3; HLA-DPB1; HLA-DOA; PTPRN2; HLA-DQB1; HLA-E; HLA-DRB1; GAD1; HLA-DRB4
    Leishmaniasis TRAF6; HLA-DOB; TLR2; IRAK1; HLA-DRA; IL1B; ITGAM; NFKBIB; H2-AA; MAPK13
    Toxoplasmosis XIAP; IRAK1; AKT1; IL12A; PPIF; MYD88; HLA-DOA; LAMA3; TLR2; HSPA1A
    Staphylococcus aureus infection SELP; CFB; C1QA; ITGB2L; DSG1; FCGR1; MASP1; ITGAM; ITGAL; DSG1C
    Tuberculosis H2-AB1; VDR; HLA-DRA; MRC1; RELA; Il23a; CD209B; RAB5B; ATP6V0D1; IFNA17
    Influenza A IL18; PABPN1L; BMA1; BLB1; DDX39B; LOC100686744; IRF3; VDAC1; HSPA8; STAT1
    HTLV-I infection ANAPC2; HLA-B; PRKACG; IL6; CREM; WNT3; RB1; DLG1; APC; PTTG1
    Herpes simplex infection HMGN1; EIF2AK1; TNF; PILRA; FB06F03; IKBKE; EIF2S1B; IFNB; ABCB3L1; HCFC1B
    Epstein-Barr virus infection IKBKB; PTMA; PIK3R5; CD38; MAPK9; SHFM1; NFKB1; RELB; PSMD11; HSPA1A
    Autoi Ifna15; HLA-DRB5; IFNA10; IFNA7; IFNA12; IFNA14; H2-Q10; HLA-DQA1; IFNA13; H2-AB1
    ne thyroid disease IFNA14; TG; IFNA17; IFNA2; HLA-DRA; PRF1; HLA-DOA; HLA-DMA; HLA-F; IL4
    Inflammatory bowel disease (IBD) HLA-DMA; NFATC1; HLA-DRB5; IL12A; SMAD2; H2-AB1; HLA-DRA; HLA-DQA2; TGFB3; MAF
    Systemic lupus erythematosus HIST2H3A; HIST1H2BQ; H2AFB1; C1QB; C5; GM14477; HIST1H2BK; HIST1H3G; H2AFY2; C8G
    Rheumatoid arthritis TGFB2; LTB; ATP6V0B; CCL3L1; ATP6V0E; Ccl12; ATP6V1B2; H2-AA; HLA-DRB4; ATP6V0A1
    Allograft rejection HLA-DRB4; CD28; HLA-DQB1; HLA-C; PRF1; HLA-DRB1; IL12B; HLA-DRB3; CD40LG; H2-AA
    Graft-versus-host disease HLA-DMB; HLA-DRB5; Il2; FASLG; FAS; HLA-A; HLA-DRA; GZMB; H2-AA; KLRD1
    Viral myocarditis CYCS; ICAM1; CD28; ACTB; HLA-B; SGCD; HLA-DRB4; H2-AA; HLA-DQA2; SGCG

    HLA-DRB4 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB4 itself. We selected most functions HLA-DRB4 had, and list some proteins which have the same functions with HLA-DRB4. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DQB1; KRT17; HLA-DQB2; HLA-DOA; HLA-DQA1; HLA-DOB; HLA-DRB4; HLA-DRB1; HLA-DRB3; HLA-DPA1
    peptide antigen binding BF2; HLA-DQB1; H2-AB1; TRGV3; MHC1ZKA; MHC1ZHA; H2-AA; MHC1UEA; MHC1UKA; HLA-G
    protein binding HADHA; SAP18; SYCE2; PDS5A; KCNJ3; FOXP4; SMCO3; SRM; PDLIM7; ADRA2C

    HLA-DRB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB4.


    Rasmussen, S; Donskov, F; et al. Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 35:487-496(2013).
    Resse, M; Paolillo, R; et al. Anti-HLA-A, -B, -DR,-DQB1 and-DQA1 antibodies reactive epitope determination with HLAMatchmaker in multipare awaiting list for heart transplant. HUMAN IMMUNOLOGY 74:937-941(2013).

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