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Official Full Name HNF1 homeobox B
Background This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms HNF1B; HNF1 homeobox B; TCF2, transcription factor 2, hepatic; LF B3; variant hepatic nuclear factor; hepatocyte nuclear factor 1-beta; HNF1beta; LFB3; MODY5; VHNF1; TCF-2; HNF-1B; HNF-1-beta; HNF1 beta A; homeoprotein LFB3; transcription factor 2, hepat
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hnf1b-6335M Recombinant Mouse Hnf1b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human HNF1B-13862H Recombinant Human HNF1B, GST-tagged E.coli GST
    Human HNF1B-29461TH Recombinant Human HNF1B Wheat Germ N/A
    Human HNF1B-4892H Recombinant Human HNF1B Protein, GST-tagged Wheat Germ GST
    Human HNF1B-5460HCL Recombinant Human HNF1B 293 Cell Lysate HEK293 N/A
    Human HNF1B-564H Recombinant Human HNF1B Protein, His-tagged E.coli His
    Mouse HNF1B-7751M Recombinant Mouse HNF1B Protein Mammalian Cell His
    Rat HNF1B-2877R Recombinant Rat HNF1B Protein Mammalian Cell His
    Rhesus Macaque HNF1B-2115R Recombinant Rhesus monkey HNF1B Protein, His-tagged Mammalian Cell His

    hnf1b involved in several pathways and played different roles in them. We selected most pathways hnf1b participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with hnf1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Maturity onset diabetes of the young NKX6; HNF4G; IAPP; NR5A2; FOXA2; PDX1; MAFA; PAX6; NKX6-1; INS1

    hnf1b has several biochemical functions, for example, DNA binding, core promoter proximal region DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hnf1b itself. We selected most functions hnf1b had, and list some proteins which have the same functions with hnf1b. You can find most of the proteins on our site.

    Function Related Protein
    core promoter proximal region DNA binding HNF1B
    protein binding FAM86C; CKS1B; CST9L; OAS1A; NAT8; RAB3IL1; GJB6; FOXP3; LMX1A; SHKBP1
    protein complex binding CCND1; ANKRD32; KHDRBS1; CDK4; NCOA1; NCKAP1L; STRN4; LCK; PPP1R9B; THRA
    protein heterodimerization activity PDZD7; TAP1; UGT1A1; CHUK; CHRNA3; CLNS1A; OSTB; TGFB2; SOX4; MAFA
    protein homodimerization activity CDA; STK25; KCNN2; TGFB2; IL6R; TIMELESS; LRRFIP1; RCHY1; RPL7; COMMD1
    sequence-specific DNA binding HOXD12A; CLOCK; HOXD4A; ARXA; FOXF2A; CREB3L3A; CREB3L1; ETS1; RX3; HOXA11
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding SOX9; SNAI2; USF2; RFX3; TFAP4; ATF2; JUN; HNF4A; GTF2IRD1; SRF
    transcription factor activity, sequence-specific DNA binding CREBZF; FOXF2; VDRB; FOXJ1; Aff1; SHOX; ATF5A; TGIF2; PURBA; BRD8

    hnf1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hnf1b here. Most of them are supplied by our site. Hope this information will be useful for your research of hnf1b.


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