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HNRNPD

  • Official Full Name

    heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)

  • Overview

    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
  • Synonyms

    HNRNPD; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); AUF1, heterogeneous nuclear ribonucleoprotein D (AU rich element RNA binding protein 1, 37kD) , HNRPD; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HNRNPD-713H Recombinant Human HNRNPD Protein, His-tagged E.coli His
Human HNRNPD-4914H Recombinant Human HNRNPD Protein, GST-tagged Wheat Germ GST
Human HNRNPD-13869H Recombinant Human HNRNPD, GST-tagged E.coli GST 1-306a.a.
Human HNRNPD-5448HCL Recombinant Human HNRNPD 293 Cell Lysate HEK293 N/A
Human HNRNPD-373H Recombinant Human HNRNPD Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HNRNPD-220H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HNRNPD-004H Recombinant Human HNRNPD Protein, His-tagged E. coli His
Human HNRNPD-003H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HNRNPD-2638H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HNRNPD-001H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HNRNPD-799H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HNRNPD-5186H Recombinant Human HNRNPD protein, GST-tagged E.coli GST 18-306aa
Human HNRNPD-5765H Recombinant Human HNRNPD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HNRNPD-002H Recombinant Human HNRNPD Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human HNRNPD-2053HFL Recombinant Full Length Human HNRNPD Protein, C-Flag-tagged Mammalian cells Flag
Human HNRNPD-3681HF Recombinant Full Length Human HNRNPD Protein, GST-tagged In Vitro Cell Free System GST 355 amino acids
Human HNRNPD-1086H-B Recombinant Human HNRNPD Protein Pre-coupled Magnetic Beads HEK293
Human HNRNPD-1086H Recombinant Human HNRNPD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HNRNPD-7761M Recombinant Mouse HNRNPD Protein Mammalian Cell His
Mouse Hnrnpd-681M Recombinant Mouse Hnrnpd Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HNRNPD-4260M Recombinant Mouse HNRNPD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HNRNPD-4260M-B Recombinant Mouse HNRNPD Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HNRNPD-2122R Recombinant Rhesus monkey HNRNPD Protein, His-tagged Mammalian Cell His
Rhesus Macaque HNRNPD-1943R-B Recombinant Rhesus Macaque HNRNPD Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HNRNPD-1943R Recombinant Rhesus Macaque HNRNPD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HNRNPD-6181Z Recombinant Zebrafish HNRNPD Mammalian Cell His
Chicken HNRNPD-2815C Recombinant Chicken HNRNPD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HNRNPD Related Articles

HNRNPD involved in several pathways and played different roles in them. We selected most pathways HNRNPD participated on our site, such as AUF1 (hnRNP D0) binds and destabilizes mRNA, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRNPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AUF1 (hnRNP D0) binds and destabilizes mRNAHNRNPD;EIF4G1;PSMA8;PSMD14;PSME3;PSMD5;PSMD9;PSMD10
Gene ExpressionSETA;NR1D2B;COX16;APEH;BRF1;ZNF263;MED31;ZNF334;TBX5A
Processing of Capped Intron-Containing Pre-mRNACD2BP2;HNRNPD;THOC4;HNRNPUL1;HNRNPA0L;PCBP2;SLBP;SNRNP48;HNRNPH1L
Regulation of mRNA stability by proteins that bind AU-rich elementsKHSRP;SET;SETA;TNPO1;ZFP36L1A;HNRNPD;ZFP36L1;ZFP36L1B;SETB
mRNA SplicingSF3B2;HNRNPH2;SUGP1;SFRS3A;PTBP1B;HNRNPH1L;SF3A1;PRPF8;BCAS2
mRNA Splicing - Major PathwayHNRNPD;HNRNPA0B;HNRNPA0L;TXNL4A;CCAR1;HNRPL;HNRNPF;PRPF8;PCBP2
mRNA processingSF3B2;RBM12B1;CLK4;Akap17b;PTBP2;ZFP830;RBM12B2;BICC1;PRPF4B

HNRNPD has several biochemical functions, for example, RNA binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRNPD itself. We selected most functions HNRNPD had, and list some proteins which have the same functions with HNRNPD. You can find most of the proteins on our site.

Function Related Protein
RNA bindingUMPS;SRP14;PTBP2A;RPS4Y1;RBMS1;RBMX;THOC3;NOVA2;KHDRBS1B
nucleotide bindingDDX39AA;VPS11;CLCN3;DCKL1B;IFT22;RALAA;ITPA;DCLK2;ACTG2
poly(A) RNA bindingDDX3X;MRPL1;PRAC;DHX8;RPS12;ARL6IP4;FRG1;HIST1H4N;GRB2
protein bindingNTN4;CISD2;RBFA;PITX2;ITM2C;STEAP3;TOB1A;C1orf216;SHOC2
telomeric DNA bindingCDAN1;SMG6;TERFA;HNRNPD;TP53BP1;XRCC5;TERF2;CTC1;TERF1

HNRNPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRNPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRNPD.

ING4; HNRNPU; LDHAL6B; Cep152; Kif1c; Shoc2; ACTB; EXOSC2; HNRNPC; SNRPC

Komlosi, K; Duga, B; et al. Phenotypic variability in a Hungarian patient with the 4q21 microdeletion syndrome. MOLECULAR CYTOGENETICS 8:-(2015).
Ishii, T; Hayakawa, H; et al. Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells. FREE RADICAL BIOLOGY AND MEDICINE 79:109-116(2015).
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