HOMER2

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HOMER2

Official Full Name homer homolog 2 (Drosophila)
Background This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14.
Synonyms HOMER2; homer homolog 2 (Drosophila); homer protein homolog 2; CPD; Cupidin; HOMER 2; HOMER 2A; HOMER 2B; Vesl 2; ACPD; HOME2_HUMAN; Homer homolog 3; Homer neuronal immediate early gene 2; Homer-2; HOMER2A; HOMER2B; Vesl2; homer, neuronal immediate early gene, 2; VESL-2
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HOMER2-13880H Recombinant Human HOMER2, GST-tagged E.coli GST
    Human HOMER2-1697H Recombinant Human HOMER2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HOMER2-2252H Recombinant Human HOMER2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HOMER2-440H Recombinant Human HOMER2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HOMER2-4925H Recombinant Human HOMER2 Protein, GST-tagged Wheat Germ GST
    Human HOMER2-5437HCL Recombinant Human HOMER2 293 Cell Lysate HEK293 N/A
    Human HOMER2-5768H Recombinant Human HOMER2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Homer2-3426M Recombinant Mouse Homer2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse HOMER2-7776M Recombinant Mouse HOMER2 Protein Mammalian Cell His
    Rat HOMER2-2888R Recombinant Rat HOMER2 Protein Mammalian Cell His
    Zebrafish HOMER2-2809Z Recombinant Zebrafish HOMER2 Mammalian Cell His

    HOMER2 involved in several pathways and played different roles in them. We selected most pathways HOMER2 participated on our site, such as FoxO signaling pathway, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOMER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PIK3R5; INS2; CCNB1; AKT2L; CAT; PRKAG1; GABARAPA; SMAD3; SGK3; FOXO3A
    Glutamatergic synapse GRM2; GRIA3; GNAS; GLS; GNG12; GRM3; SHANK3; SLC1A7; SLC38A3; MAPK1

    HOMER2 has several biochemical functions, for example, G-protein coupled glutamate receptor binding, GKAP/Homer scaffold activity, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOMER2 itself. We selected most functions HOMER2 had, and list some proteins which have the same functions with HOMER2. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled glutamate receptor binding HOMER3; HOMER1; HOMER2; HOMER1B
    GKAP/Homer scaffold activity SHANK3; SHANK1; HOMER2
    actin binding CFL2L; FBXO25; SPATA31; SPIRE1; CYFIP1; DMTN; ARPC1A; LCP1; VPS16; SSH3
    protein binding HIST1H2AG; MARK2; STRN; PPP2R5A; FGFRL1A; U2AF2; FYCO1; COQ9; APC2; BCL2L16
    protein domain specific binding WNT3; YWHAE1; YWHAG1; HIST1H4D; ETV6; DRD3; YWHAQA; HIST1H4F; DBNL; RAB27B
    protein heterodimerization activity LIFR; TAF12; H2-AA; TAS1R1; RALGAPA2; SIM2; RBP4; UGT1A9; H2AFVB; DDX1
    protein homodimerization activity PON1; AIMP1; DMRT3; TENM2; PVRL2; SDCBP; TPD52L1; NFKB1; CAMK2D; FLRT3

    HOMER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOMER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOMER2.

    LZTS2; RNF41; APP; KPNA2

    Jing, X; Chen, SS; et al. Diagnostic Potential of Differentially Expressed Homer1, IL-1 beta, and TNF-alpha in Coronary Artery Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:535-546(2015).
    Gould, AT; Sacramento, AD; et al. Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse. ADDICTION BIOLOGY 20:148-157(2015).

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