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Official Full Name heparan sulfate 2-O-sulfotransferase 1
Background Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
Synonyms HS2ST1; heparan sulfate 2-O-sulfotransferase 1; KIAA0448; 2OST; 2-O-sulfotransferase; dJ604K5.2; FLJ11317; MGC131986
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • HIS
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HS2ST1-105H Recombinant Human HS2ST1, His-tagged CHO HIS
    Human HS2ST1-1591H Recombinant Human HS2ST1 protein, His & T7-tagged E.coli His/T7
    Human HS2ST1-5047H Recombinant Human HS2ST1 Protein, GST-tagged Wheat Germ GST
    Human HS2ST1-5388HCL Recombinant Human HS2ST1 293 Cell Lysate HEK293 N/A
    Mouse HS2ST1-7855M Recombinant Mouse HS2ST1 Protein Mammalian Cell His
    Rhesus Macaque HS2ST1-2145R Recombinant Rhesus monkey HS2ST1 Protein, His-tagged Mammalian Cell His
    Chicken HS2ST1-6051C Recombinant Chicken HS2ST1 Mammalian Cell His

    hs2st1 involved in several pathways and played different roles in them. We selected most pathways hs2st1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, which may be useful for your reference. Also, other proteins which involved in the same pathway with hs2st1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST3B1; EXT1B; HS6ST3B; XYLT2; NDST1; HS3ST1L1; NDST2; EXTL3; HS2ST1A; GLCEA

    hs2st1 has several biochemical functions, for example, heparan sulfate 2-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hs2st1 itself. We selected most functions hs2st1 had, and list some proteins which have the same functions with hs2st1. You can find most of the proteins on our site.

    Function Related Protein
    heparan sulfate 2-O-sulfotransferase activity SULT1ST8; CHST3A; HS6ST3B; SULT2ST3; HS3ST3L; SULT3ST3; SULT1ST6; HS3ST1L1; SULT1ST2; HS6ST1A

    hs2st1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hs2st1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hs2st1.


    Nakayama, F; Hagiwara, A; et al. Hydrogen peroxide as a potential mediator of the transcriptional regulation of heparan sulphate biosynthesis in keratinocytes. CELLULAR & MOLECULAR BIOLOGY LETTERS 13:475-492(2008).

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