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Official Full Name heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Background This gene encodes the enzyme heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates 3-O-sulfated;glucosaminyl residues in heparan sulfate. Cell surface heparan sulfate is used as a receptor by herpes simplex virus;type 1 (HSV-1), and expression of this gene is thought to play a role in HSV-1 pathogenesis.
Synonyms HS3ST4; heparan sulfate (glucosamine) 3-O-sulfotransferase 4; heparan sulfate glucosamine 3-O-sulfotransferase 4; 3OST4; heparan sulfate 3-O-sulfotransferase 4; heparan sulfate 3-O-sulfotransferase-4; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 4; 30ST4; 3-OST-4; h3-OST-4;
    • Species :
    • Human
    • Zebrafish
    • Source :
    • CHO
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HS3ST4-1971H Recombinant Human Heparan Sulfate (glucosamine) 3-O-Sulfotransferase 4, His-tagged CHO His
    Human HS3ST4-5054H Recombinant Human HS3ST4 Protein Wheat Germ N/A
    Human HS3ST4-5055H Recombinant Human HS3ST4 Protein, GST-tagged Wheat Germ GST
    Human HS3ST4-564H Recombinant Human HS3ST4 Protein, His-tagged CHO His
    Zebrafish HS3ST4-5085Z Recombinant Zebrafish HS3ST4 Mammalian Cell His

    hs3st4 involved in several pathways and played different roles in them. We selected most pathways hs3st4 participated on our site, such as Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with hs3st4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan metabolism ST3GAL3A; MAPK1IP1L; HS3ST4; STAB2; B3GAT2; GPC1A; HPSE; CHP; DSEL; BGNB
    HS-GAG biosynthesis HS3ST6; GPC5A; GPC1B; MAPK1IP1L; SLC35D2; HS3ST4; Gpc2; GPC1A
    Heparan sulfate/heparin (HS-GAG) metabolism CSPG5B; GLB1L; GPC1B; HS3ST4; HPSE; B3GAT2; GPC1A; Gpc2; SLC35D2; MAPK1IP1L
    Metabolism ACY3.1; B3GNT2A; DUT; CYP2AD6; NAGS; AKR1C21; HAS1; DPEP2; NDUFAF5; CYP2Y3
    Metabolism of carbohydrates Gpc2; KHK; LYVE1; GCKR; SLC25A1; KIAA1199; GYG1A; SLC25A11; HS3ST4; GLB1L
    heparan sulfate biosynthesis MAPK1IP1L; A4GNT; HS3ST4
    heparan sulfate biosynthesis (late stages) A4GNT; HS3ST4
    metapathway biotransformation SULT6B1; CYP20A1; CHST9; CEACAM21; NAA50; KCNAB2; CHST4; NAT8; GAL3ST3; SULT1B1

    hs3st4 has several biochemical functions, for example, [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hs3st4 itself. We selected most functions hs3st4 had, and list some proteins which have the same functions with hs3st4. You can find most of the proteins on our site.

    Function Related Protein
    [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity HS3ST6; HS3ST5; HS3ST1; HS3ST4; HS3ST3B1

    hs3st4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hs3st4 here. Most of them are supplied by our site. Hope this information will be useful for your research of hs3st4.

    Brusilovsky, M; Cordoba, M; et al. Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses. JOURNAL OF IMMUNOLOGY 191:5256-5267(2013).
    Pempe, EH; Burch, TC; et al. Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate. GLYCOBIOLOGY 22:1353-1362(2012).

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