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Official Full Name hydroxysteroid (17-beta) dehydrogenase 4
Background The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
Synonyms HSD17B4; hydroxysteroid (17-beta) dehydrogenase 4; peroxisomal multifunctional enzyme type 2; 3 alpha; 7 alpha; 12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogena
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Hsd17b4-1180M Recombinant Mouse Hsd17b4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human HSD17B4-1417H Recombinant Human HSD17B4 Protein (1-736 aa), His-tagged Yeast His
    Human HSD17B4-109H Recombinant Human HSD17B4, His-tagged HEK293 His
    Human HSD17B4-110H Recombinant Human HSD17B4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HSD17B4-111H Recombinant Human HSD17B4 protein, GST-tagged Wheat Germ GST
    Human HSD17B4-13960H Recombinant Human HSD17B4, GST-tagged E.coli GST
    Human HSD17B4-5373HCL Recombinant Human HSD17B4 293 Cell Lysate HEK293 N/A
    Mouse HSD17B4-7879M Recombinant Mouse HSD17B4 Protein Mammalian Cell His
    Rat HSD17B4-2928R Recombinant Rat HSD17B4 Protein Mammalian Cell His
    Chicken HSD17B4-6503C Recombinant Chicken HSD17B4 Mammalian Cell His
    Zebrafish HSD17B4-10487Z Recombinant Zebrafish HSD17B4 Mammalian Cell His

    hsd17b4 involved in several pathways and played different roles in them. We selected most pathways hsd17b4 participated on our site, such as Primary bile acid biosynthesis, Metabolic pathways, Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd17b4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary bile acid biosynthesis SCP2; SLC27A5; SCP2A; CH25HL2; ACOX2; CYP46A1.2; CYP46A1.1; AMACR; CYP46A1.4; CYP7B1
    Metabolic pathways CDS1; ctaG; PSPH; MVDA; GALNT18A; BCKDHB; UAP1L1; NME3; GCNT4; PI4K2A
    Peroxisome DDO; ACSL4; SCP2A; XDH; PAOX; DAO.3; MPV17L; CAT; ACSL1; ECH1

    hsd17b4 has several biochemical functions, for example, 17-beta-hydroxysteroid dehydrogenase (NAD+) activity, 3-hydroxyacyl-CoA dehydrogenase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd17b4 itself. We selected most functions hsd17b4 had, and list some proteins which have the same functions with hsd17b4. You can find most of the proteins on our site.

    Function Related Protein
    17-beta-hydroxysteroid dehydrogenase (NAD+) activity HSD17B4
    3-hydroxyacyl-CoA dehydrogenase activity HSD17B10; HSD17B8; HADHA; HADHAA; HADHAB; HSD17B4; H2-KE6; HADH; HADHB; EHHADH
    3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity HSD17B4
    isomerase activity GPR19; PPIFB; PBLD1; PDIP5; PDIA5; PGAM1A; BPGM; FKBP1AB; PTGESL; GPIB
    long-chain-enoyl-CoA hydratase activity HSD17B4; HADHA
    protein homodimerization activity S100A5; ZFP365; MZF1; CADM2A; TESC; GRM6; DMRTA1; TPD52L1; PKD2; Flt3l
    receptor binding CNPY3; SSTR3; DECR2; MSTN; DDX54; AMN; CXCL12; CNTFR; FGG; INHA

    hsd17b4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd17b4 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd17b4.

    PLEK; GSK3B; RELB; NDRG1; UBA5; MAPK8; CDK7; CASP9; BAK1; q74yg8_yerpe; midostaurin; ssrna_ag

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