Recombinant Human HSD17B4 protein, GST-tagged

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Recombinant Human HSD17B4 protein, GST-tagged

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Cat.No. : HSD17B4-111H
Product Overview : Recombinant Human HSD17B4(1 a.a. - 736 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
Description : The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 107.36 kDa
Protein length : 1 a.a. - 736 a.a.
AA Sequence : MGSPLRFDGRVVLVT GAGAGLGRAYALAFA ERGALVVVNDLGGDF KGVGKGSLAADKVVE EIRRRGGKAVANYDS VEEGEKVVKTALDAF GRIDVVVNNAGILRD RSFARISDEDWDIIH RVHLRGSFQVTRAAW EHMKKQKYGRIIMTS SASGIYGNFGQANYS AAKLGLLGLANSLAI EGRKSNIHCNTIAPN AGSRMTQTVTPEDLV EALKPEYVAPLVLWL CHESCEENGGLFEVG AGWIGKLRWERTLGA IVRQKNHPMTPEAVK ANWKKICDFENASKP QSIQESTGSIIEVLS KIDSEGGVSANHTSR ATSTATSGFAGAIGQ KLPPFSYAYTELEAI MYALGVGASIKDPKD LKFIYEGSSDFSCLP TFGVIIGQKSMMGGG LAEIPGLSINFAKVL HGEQYLELYKPLPRA GKLKCEAVVADVLDK GSGVVIIMDVYSYSE KELICHNQFSLFLVG SGGFGGKRTSDKVKV AVAIPNRPPDAVLTD TTSLNQAALYRLSGD RNPLHIDPNFASLAG FDKPILHGLCTFGFS ARRVLQQFADNDVSR FKAVKARFAKPVYPG QTLQTEMWKEGNRIH FQTKVQETGDIVISN AYVDLAPTSGTSAKT PSEGGKLQSTFVFEE IGRRLKDIGPEVVKK VNAVFEWHITKGGNI GAKWTIDLKSGSGKV YQGPAKGAADTTIIL SDEDFMEVVLGKLDP QKAFFSGRLKARGNI MLSQKLQMILKDYAK L
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 [ Homo sapiens ]
Official Symbol : HSD17B4
Synonyms : HSD17B4; hydroxysteroid (17-beta) dehydrogenase 4; peroxisomal multifunctional enzyme type 2; 3 alpha; 7 alpha; 12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase 4; 17beta estradiol dehydrogenase type IV; beta hydroxyacyl dehydrogenase; beta keto reductase; D 3 hydroxyacyl CoA dehydratase; D bifunctional protein; peroxisomal; DBP; MFE 2; peroxisomal multifunctional protein 2; SDR8C1; short chain dehydrogenase/reductase family 8C; member 1; 17-beta-HSD 4; 17-beta-HSD IV; beta-keto-reductase; multifunctional protein 2; beta-hydroxyacyl dehydrogenase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein, peroxisomal; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; short chain dehydrogenase/reductase family 8C, member 1; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; MFE-2; MPF-2;
Gene ID : 3295
mRNA Refseq : NM_000414
Protein Refseq : NP_000405
MIM : 601860
UniProt ID : P51659
Chromosome Location : 5q2
Pathway : Beta-oxidation of pristanoyl-CoA, organism-specific biosystem; Beta-oxidation of very long chain fatty acids, organism-specific biosystem; Bile acid and bile salt metabolism, organism-specific biosystem; Bile acid biosynthesis, cholesterol => cholate, organism-specific biosystem; Bile acid biosynthesis, cholesterol => cholate, conserved biosystem;
Function : 3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; estradiol 17-beta-dehydrogenase activity; isomerase activity; long-chain-enoyl-CoA hydratase activity; lyase activity; nucleotide binding; oxidoreductase activity; sterol binding; sterol transporter activity;

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