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Official Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Background 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.
Synonyms HSD3B1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; HSD3B, HSDB3; 3 beta-hydroxysteroid dehydrogenase/Delta 5--> 4-isomerase type 1; SDR11E1; short chain dehydrogenase/reductase family 11E; member 1; 3 beta-hydroxystero
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD3B1-22H Recombinant Human HSD3B1 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human HSD3B1-4934H Recombinant Human HSD3B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HSD3B1-5078H Recombinant Human HSD3B1 Protein, GST-tagged Wheat Germ GST
    Human HSD3B1-5370HCL Recombinant Human HSD3B1 293 Cell Lysate HEK293 N/A
    Mouse Hsd3b1-1182M Recombinant Mouse Hsd3b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse HSD3B1-7882M Recombinant Mouse HSD3B1 Protein Mammalian Cell His
    Rat HSD3B1-2933R Recombinant Rat HSD3B1 Protein Mammalian Cell His
    Zebrafish HSD3B1-12064Z Recombinant Zebrafish HSD3B1 Mammalian Cell His

    hsd3b1 involved in several pathways and played different roles in them. We selected most pathways hsd3b1 participated on our site, such as Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd3b1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis SRD5A2A; HSD17B12B; UGT1A7C; UGT2B15; HSD11B2; HSD17B8; CYP2B19; SRD5A3; UGT1A7; CYP2D10
    Metabolic pathways ALDOCA; HEXB; BDH1; PYGL; CYP1A; B3GNT1; NME2B.1; PCYT2; HMBSB; IDUA
    Ovarian steroidogenesis PLA2G4C; CYP2J5; PRKACB; BMP15; HSD3B1; PLA2G4D; ALOX5; LHB; INS2; IGF1R
    Aldosterone synthesis and secretion DAGLB; CALM1; PRKACG; ATF4; CYP21A1; ADCY8; Adcy4; SLC14A2; KCNK9; PRKCG

    hsd3b1 has several biochemical functions, for example, 3-beta-hydroxy-delta5-steroid dehydrogenase activity, steroid delta-isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd3b1 itself. We selected most functions hsd3b1 had, and list some proteins which have the same functions with hsd3b1. You can find most of the proteins on our site.

    Function Related Protein
    3-beta-hydroxy-delta5-steroid dehydrogenase activity HSD3B5; HSD3B7; HSD3B6; HSD3B2; HSD3B1; HSD3B4; NSDHL; SDR42E1
    steroid delta-isomerase activity HSD3B2; EBP; HSD3B6; HSD3B1

    hsd3b1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd3b1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd3b1.

    Doi, M; Satoh, F; et al. Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E257-E262(2014).
    Chou, YY; Jeng, YM; et al. HSD3B1 Is a Specific Trophoblast-Associated Marker Not Expressed in a Wide Spectrum of Tumors. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 23:343-347(2013).

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