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Official Full Name 5-hydroxytryptamine (serotonin) receptor 1A
Background This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the;5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and;pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and;stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic;fevers.
Synonyms HTR1A; 5-hydroxytryptamine (serotonin) receptor 1A; 5-hydroxytryptamine receptor 1A; 5 HT1A receptor; 5 HT 1A; 5 HT receptor 1A; 5 HT1A; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; 5HT 1A; 5HT 1A receptor; 5HT receptor 1A; 5HT1A_HUMAN; ADRB2RL1; ADRBRL1; G 21; G protein coupled receptor; G-21; Gpcr 18; Gpcr18; Guanine nucleotide binding regulatory protein-coupled receptor; Serotonin 1A receptor; Serotonin 5HT1A receptor; Serotonin receptor 1A; 5HT1A; RAT5HT1A
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HTR1A-148H Recombinant Human HTR1A Mammalian Cell His
    Human HTR1A-25H Recombinant Human HTR1A protein Wheat Germ N/A
    Human HTR1A-26H Recombinant Human HTR1A protein, GST-tagged Wheat Germ GST
    Human HTR1A-27H Recombinant Human HTR1A protein, GST-tagged Wheat Germ GST
    Rat HTR1A-2959R Recombinant Rat HTR1A Protein Mammalian Cell His
    Rhesus Macaque HTR1A-2173R Recombinant Rhesus monkey HTR1A Protein, His-tagged Mammalian Cell His
    Chicken HTR1A-4048C Recombinant Chicken HTR1A Mammalian Cell His
    Kit-0995 Total Collagen Assay Kit (Perchlorate-Free) N/A
    Kit-1349 HTR1A CHO-K1 β-Arrestin GPCR Assay Kit N/A

    htr1a involved in several pathways and played different roles in them. We selected most pathways htr1a participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with htr1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway PAK1; BAD; MAP2K2; ATP2B1; RAC2; CREB5; PDE4D; GNAS; GRIA4; MAPK10
    Neuroactive ligand-receptor interaction GABRG3; LEPB; P2RX8; LHB; HTR2B; NPY5R; CHRND; S1PR3; GRIA2B; GRIN1B
    Serotonergic synapse PRKACA; CYP2C39; TPH1; HTR6; GNB2; MAPK1; PTGS1; GNG2; GABRB3; GABRB1

    htr1a has several biochemical functions, for example, protein binding, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by htr1a itself. We selected most functions htr1a had, and list some proteins which have the same functions with htr1a. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NFASC; HDAC7A; RNMT; FCGR2A; POU2F1; GABBR2; GOLM1; IL1RAPL1; TRIM2; RITA1
    serotonin receptor activity HTR1D; HTR1F; HTR7; HTR1B; HTR2CL1; HTR1A; HTR3E; HTR2B; HTR1E; HTR2C

    htr1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with htr1a here. Most of them are supplied by our site. Hope this information will be useful for your research of htr1a.

    Matthews, PR; Harrison, PJ; et al. A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. JOURNAL OF AFFECTIVE DISORDERS 137:125-134(2012).
    Xu, J; Zhang, GL; et al. Hypomethylation of the HTR1A promoter region and high expression of HTR1A in the peripheral blood lymphocytes of patients with systemic lupus erythematosus. LUPUS 20:678-689(2011).

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