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Official Full Name 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Background Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations.
Synonyms HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2C , HTR1C; 5-hydroxytryptamine receptor 2C; 5 HT2C; 5-HT1C; 5-HT-1C; 5-HT-2C; serotonin receptor 2C; serotonin 5-HT-2C receptor; 5-hydroxytryp
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HTR2C-26028TH Recombinant Human HTR2C Wheat Germ N/A
    Human HTR2C-5241H Recombinant Human HTR2C Protein, GST-tagged Wheat Germ GST
    Mouse HTR2C-7934M Recombinant Mouse HTR2C Protein Mammalian Cell His
    Rat HTR2C-2964R Recombinant Rat HTR2C Protein Mammalian Cell His
    Kit-0933 TR-FRET ERR gamma Coactivator Assay Kit, goat N/A
    Kit-1013 Cardiolipin Assay Kit (Fluorometric) N/A
    Kit-1018 D-Gluconate (D-Gluconic Acid) Assay Kit (Colorimetric) N/A
    Kit-1020 Fructosamine Assay Kit (Colorimetric) N/A
    Kit-1353 HTR2C U2OS β-Arrestin GPCR Assay Kit N/A
    Kit-1354 HTR2C Activated GPCR Internalization Assay Kit N/A
    Kit-1355 HTR2C(VGV) U2OS β-Arrestin GPCR Assay Kit N/A
    Kit-1356 HTR2C(VNV) U2OS β-Arrestin GPCR Assay Kit N/A
    Kit-1357 HTR2C(VSV) U2OS β-Arrestin GPCR Assay Kit N/A

    htr2c involved in several pathways and played different roles in them. We selected most pathways htr2c participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with htr2c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway DRD5; DRD1A; TMEM8C; SLC25A5; CAMK2D2; PDE1A; ITPKC; PHKG1B; TACR2; ADORA2AB
    Neuroactive ligand-receptor interaction GPR35; VIPR2; PTH2R; BRS3; P2RX4B; GRIN1; TAAR12I; NPY4R; TBXA2R; CHRNA5
    Serotonergic synapse GNG13; CYP2C50; ARAF; RAF1; HTR1B; CYP2C39; ALOX12B; PLA2G4D; GNGT1; PLA2G4C
    Inflammatory mediator regulation of TRP channels MAPK10; PLCG2; F2RL1; PLCB1; CYP2C54; ASIC2; ACCN3; PLCB3; MAPK8; PIK3R2

    htr2c has several biochemical functions, for example, 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, Gq/11-coupled serotonin receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by htr2c itself. We selected most functions htr2c had, and list some proteins which have the same functions with htr2c. You can find most of the proteins on our site.

    Function Related Protein
    1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding HTR2A; HTR2C
    Gq/11-coupled serotonin receptor activity HTR2C
    drug binding PYGM; CYP2D6; FOLR1; ADRB2; HTR2C; DCK; P2RX1; PNP; CHRNB4; GPR30
    serotonin binding HTR1B; HTR1E; MAOA; HTR2A; HTR2C; HTR3A; HTR1F; HTR2B
    serotonin receptor activity HTR2B; HTR1AB; HTR3B; HTR3A; HTR1AA; HTR7; HTR1F; HTR2C; HTR5A; HTR1A

    htr2c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with htr2c here. Most of them are supplied by our site. Hope this information will be useful for your research of htr2c.

    MPDZ; mesulergine; Arrb2; Mpdz

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