HTR2C

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

  • Overview

    Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations.
  • Synonyms

    HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2C , HTR1C; 5-hydroxytryptamine receptor 2C; 5 HT2C; 5-HT1C; 5-HT-1C; 5-HT-2C; serotonin receptor 2C; serotonin 5-HT-2C receptor; 5-hydroxytryp;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR2C-26028TH Recombinant Human HTR2C Wheat Germ N/A 52 amino acids
Human HTR2C-1092HFL Recombinant Human HTR2C protein, His&Flag-tagged HEK293 His&Flag 1-458 aa
Human HTR2C-5241H Recombinant Human HTR2C Protein, GST-tagged Wheat Germ GST
Mouse HTR2C-7934M Recombinant Mouse HTR2C Protein Mammalian Cell His
Mouse HTR2C-4376M Recombinant Mouse HTR2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HTR2C-4376M-B Recombinant Mouse HTR2C Protein Pre-coupled Magnetic Beads HEK293
Rat HTR2C-2964R Recombinant Rat HTR2C Protein Mammalian Cell His
Rat HTR2C-2619R-B Recombinant Rat HTR2C Protein Pre-coupled Magnetic Beads HEK293
Rat HTR2C-2619R Recombinant Rat HTR2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canis lupus familiaris (Dog) (Canis familiaris) RFL5529CF Recombinant Full Length Dog 5-Hydroxytryptamine Receptor 2C(Htr2C) Protein, His-Tagged E.coli expression system His Full Length (1-458)
Homo sapiens (Human) RFL14239HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 2C(Htr2C) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-458)
Mus musculus (Mouse) RFL14531MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 2C(Htr2C) Protein, His-Tagged E.coli expression system His Full Length (1-459)
Pan troglodytes (Chimpanzee) RFL12961PF Recombinant Full Length Pan Troglodytes 5-Hydroxytryptamine Receptor 2C(Htr2C) Protein, His-Tagged E.coli expression system His Full Length (1-458)
Rattus norvegicus (Rat) RFL9813RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 2C(Htr2C) Protein, His-Tagged E.coli expression system His Full Length (1-460)
Kit-1013 Cardiolipin Assay Kit (Fluorometric) N/A
Kit-1018 D-Gluconate (D-Gluconic Acid) Assay Kit (Colorimetric) N/A
Kit-1355 HTR2C(VGV) U2OS β-Arrestin GPCR Assay Kit N/A
Kit-0933 TR-FRET ERR gamma Coactivator Assay Kit, goat N/A
Kit-1357 HTR2C(VSV) U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1020 Fructosamine Assay Kit (Colorimetric) N/A
Kit-1356 HTR2C(VNV) U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1353 HTR2C U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1354 HTR2C Activated GPCR Internalization Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

HTR2C involved in several pathways and played different roles in them. We selected most pathways HTR2C participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPLN;P2RX6;CAMK2D2;DRD1A;MYLK3;DRD5;CALM3A;ATP2B1A;PHKA1
Neuroactive ligand-receptor interactionVIPR2;RXFP4;GRM6A;MC3R;BDKRB2;TAAR12G;GABRB3;GABRB2;PTGER3
Gap junctionTUBA8L;TUBA3D;PRKG2;MAP2K5;PDGFAA;HRASA;PRKCA;EGFRA;MAPK1
Serotonergic synapseCYP2C55;GNG12;HTR3A;GNAI2;CYP2C39;GNG4;GNG7;ALOX5;MAPK3
Inflammatory mediator regulation of TRP channelsPPP1CC;CYP4A14;TRPM8;CYP2C70;PIK3R3;CYP2C50;F2RL1;TRPV2;Adcy4

HTR2C has several biochemical functions, for example, 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, Gq/11-coupled serotonin receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2C itself. We selected most functions HTR2C had, and list some proteins which have the same functions with HTR2C. You can find most of the proteins on our site.

Function Related Protein
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingHTR2A;HTR2C
Gq/11-coupled serotonin receptor activity
drug bindingPPARA;ADH1;GPR30;DRD1;SRP54;FASN;CNR1;PPP3CA;SIGMAR1
serotonin bindingMAOA;HTR2A;HTR2C;HTR3A;HTR1F;HTR1E;HTR1B;HTR2B
serotonin receptor activityHTR2C;HTR2B;HTR5A;HTR3B;HTR2A;HTR1E;HTR6;HTR1AA;HTR1B

HTR2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2C here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2C.

MPDZ; mesulergine; Arrb2; Mpdz

Gene Family

GPCRs

Research Area

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