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Recombinant Human HTR2C Protein, GST-tagged

Cat.No. : HTR2C-5241H
Product Overview : Human HTR2C partial ORF ( NP_000859, 1 a.a. - 52 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
  • Related Products
Description : Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 31.46 kDa
AA Sequence : MVNLRNAVHSFLVHLIGLLVWQSDI SVSPVAAIVTDIFNTSDGGRFKFPD GV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [ Homo sapiens ]
Official Symbol : HTR2C
Synonyms : HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2C , HTR1C; 5-hydroxytryptamine receptor 2C; 5 HT2C; 5-HT1C; 5-HT-1C; 5-HT-2C; serotonin receptor 2C; serotonin 5-HT-2C receptor; 5-hydroxytryptamine receptor 1C; HTR1C; 5-HT2C; 5-HTR2C;
Gene ID : 3358
mRNA Refseq : NM_000868
Protein Refseq : NP_000859
MIM : 312861
UniProt ID : P28335

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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