HYAL2
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Official Full Name
hyaluronoglucosaminidase 2
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Overview
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5 UTR.[provided by RefSeq, Mar 2010] -
Synonyms
HYAL2; hyaluronoglucosaminidase 2; LUCA2; hyaluronidase-2; hyal-2; PH20 homolog; PH-20 homolog; hyaluronidase 2; lysosomal hyaluronidase; lung carcinoma protein 2; hyaluronoglucosaminidase-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- CHO
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- C
- 6×His
- GST
- His
- His (Fc)
- Avi
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HYAL2 Related Articles
HYAL2 involved in several pathways and played different roles in them. We selected most pathways HYAL2 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan degradation | HPSE2;NAGLU;SPAM1;GALNS;HEXA;GUSB;GNSA;HYAL6;GLB1 |
| Metabolic pathways | CPS1;AK9;OCRL;FUT5;FASN;INPP4B;TREH;MUT;NDUFS7 |
HYAL2 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, enzyme binding, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL2 itself. We selected most functions HYAL2 had, and list some proteins which have the same functions with HYAL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription coactivator activity | ANKRD1;SOX12;RERE;WBP2;CITED2;MKL1B;TFAP2B;CITED4;PITX2 |
| enzyme binding | HIST1H2AG;MAPT;PARP1;CYP1A1;SNRPD3;U2AF2;A2M;PPP3CA;STC2 |
| hyaluronic acid binding | VCAN;IMPG2;BCAN;ACAN;LYVE1;HMMR;KIAA1199;HAPLN4;HAPLN3 |
| hyaluronoglucuronidase activity | HYAL2;HYAL3 |
| hyalurononglucosaminidase activity | SPAM1;HYAL3;HYAL4;MGEA5;HYAL1;HYAL2;HYAL6;CD44;KIAA1199 |
| NOT hyalurononglucosaminidase activity | HYAL2;HYAL3;HYAL1 |
| protein binding | CD27;CETN1;GNAI2;ARMCX5-GPRASP2;ZNF18;TSPAN15;HEMK1;PRMT6;MAD1L1 |
| receptor signaling protein tyrosine kinase inhibitor activity | |
| receptor tyrosine kinase binding | SHC3;NRG3;FLT3LG;GNB2L1;PTPN2;PLCG1;HYAL2;MYOC;PTPN11 |
| transforming growth factor beta binding | TGFBR1;TGFBR3;LTBP4;ACVR1;TGFB3;TGFBR2;THBS1;CD109;VASN |
| virus receptor activity | ITGB1;LAMP1;CD46;SCARB2;CLEC4G;HTR2A;CD209;TYRO3;RPSA |
HYAL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL2.
FHL3; KRTAP3-2; fadE; q5nii2_fratt; pepP; yqgS
- Q&As
- Reviews
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