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Official Full Name hyaluronoglucosaminidase 2
Background This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5 UTR.[provided by RefSeq, Mar 2010]
Synonyms HYAL2; hyaluronoglucosaminidase 2; LUCA2; hyaluronidase-2; hyal-2; PH20 homolog; PH-20 homolog; hyaluronidase 2; lysosomal hyaluronidase; lung carcinoma protein 2; hyaluronoglucosaminidase-2;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HYAL2-1651H Recombinant Human HYAL2 Protein (21-448 aa), His-tagged Yeast His
    Human HYAL2-14019H Recombinant Human HYAL2, His-tagged E.coli His
    Human HYAL2-5221H Recombinant Human HYAL2 Protein, GST-tagged Wheat Germ GST
    Human HYAL2-5323HCL Recombinant Human HYAL2 293 Cell Lysate HEK293 N/A
    Mouse Hyal2-1172M Recombinant Mouse Hyal2 protein, His-tagged E.coli His
    Mouse HYAL2-7953M Recombinant Mouse HYAL2 Protein Mammalian Cell His
    Rhesus Macaque HYAL2-2180R Recombinant Rhesus monkey HYAL2 Protein, His-tagged Mammalian Cell His

    hyal2 involved in several pathways and played different roles in them. We selected most pathways hyal2 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with hyal2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan degradation GUSB; GNSA; SGSH; HPSE; HYAL3; GNSB; IDUA; HYAL1; GNS; HYAL6
    Metabolic pathways GALCA; PANK1; SMPD2; MOGS; TYRP1; PTGES3B; PIGC; PTGS2B; PHGDH; UOX

    hyal2 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, enzyme binding, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hyal2 itself. We selected most functions hyal2 had, and list some proteins which have the same functions with hyal2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription coactivator activity PRRX1; SMARCA2; ANKRD1; SOX11; POU3F2; MKL1B; PITX2; HYAL2; POU3F1; CREBBP
    enzyme binding RAD9; HSPA6; TSPYL1; UGT1A2; PTPN1; NKX2-1; PDCD2; GOT2; HIST1H2AK; MDM2
    hyaluronic acid binding VCANB; TNFAIP6; VCAN; BCAN; HAPLN3; ACAN; LYVE1; HAPLN1; IMPG2; LAYN
    hyaluronoglucuronidase activity HYAL3; HYAL2
    hyalurononglucosaminidase activity HYAL1; CD44; HYAL2; HYAL3; HYAL4; HYAL6; SPAM1; KIAA1199; MGEA5
    NOT hyalurononglucosaminidase activity HYAL2; HYAL3; HYAL1
    protein binding SKAP2; STARD10; GATAD2A; GINS4; NUDT14; COL6A2; TK1; CST7; CAPN1; SHKBP1
    receptor signaling protein tyrosine kinase inhibitor activity HYAL2
    receptor tyrosine kinase binding ZFP259; TRP53; PCNA; FLT3LG; PTPN14; ANGPT2A; PTPN1; FIZ1; SQSTM1; CPNE3
    transforming growth factor beta binding ITGAV; THBS1; LTBP1; TGFBR3; ACVR1; LTBP4; HYAL2; TGFBR1; ENG; TGFB3
    virus receptor activity ITGB6; SLC52A2; DAG1; SLAMF1; SERPINB4; ICAM1; SELPLG; ITGB3; CXCR4; DPP4

    hyal2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hyal2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hyal2.

    FHL3; KRTAP3-2; fadE; q5nii2_fratt; pepP; yqgS

    Marei, WFA; Salavati, M; et al. Critical role of hyaluronidase-2 during preimplantation embryo development. MOLECULAR HUMAN REPRODUCTION 19:590-599(2013).
    Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
    Li, LL; Asteriou, T; et al. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. BIOCHEMICAL JOURNAL 404:327-336(2007).
    Selbi, W; de la Motte, C; et al. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. KIDNEY INTERNATIONAL 70:1287-1295(2006).

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