ID1
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Official Full Name
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -
Overview
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the;basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit;the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may;play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have;been found for this gene. -
Synonyms
ID1;inhibitor of DNA binding 1, dominant negative helix-loop-helix protein;DNA-binding protein inhibitor ID-1;bHLHb24;dJ857M17.1.2;DNA binding protein inhibitor ID 1;DNA binding protein inhibitor ID1;Dominant negative helix loop helix protein;ID 1;ID;Inhibitor of Differentiation 1;Inhibitor of DNA binding 1;OTTHUMP00000030534;OTTHUMP00000030535;class B basic helix-loop-helix protein 24;dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- SUMO
- Flag
Involved Pathway
ID1 involved in several pathways and played different roles in them. We selected most pathways ID1 participated on our site, such as Rap signaling pathway,TGF-beta signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | OTX1,FGFR4,BMPR1B,PIK3CA,PIK3CG,LEFTY2,HOXB1,WNT11,REST,INHBA |
| TGF-beta signaling pathway | TGFB3,BMPR2,GDF5,BMPR1AB,LFT1,SMAD4,TGFB1,BMP6,FSTA,TGIF2 |
| Rap signaling pathway | LPAR3,FGF16,RAP1A,PIK3CA,APBB1IP,PDGFRA,INSR,CALM2,RRAS,RAC3 |
| Hippo signaling pathway | AFP,PRKCI,PPP2R2D,DLG3,PPP2R2C,SERPINE1,CRB2,PPP2R1A,STK3,GDF7 |
Protein Function
ID1 has several biochemical functions, for example, proteasome binding,protein C-terminus binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ID1 itself. We selected most functions ID1 had, and list some proteins which have the same functions with ID1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GSDMD,RNF32,CMTM5,ZNF404,GAB2,Fert2,MTAP1A,RPL23,VBP1,ADAMTS13 |
| proteasome binding | ADRM1,PSMF1,PSMD14,UBD,USP13,DNAJB2,UCHL5,BAG6,USP14,PSMG1 |
| protein homodimerization activity | SUPV3L1,PCYT1A,NR4A3,IL6ST,CADM1,EIF2AK1,EVLA,HINT2,PRMT8,PVRL1A |
| protein C-terminus binding | MIF4GD,XRCC5,BLOC1S2A,ATP1B1,JAK2,SHANK1,BCL10,XRCC6,ERCC6,C11orf60 |
| transcription factor binding | KCTD1,ZEB1,IFI16,TRERF1,DIP2C,PAX2,CEBPB,MED25,TCF7L2,TRIB1 |
| protein N-terminus binding | ERCC5,RASSF1,SDCBP,EIF3E,PIAS3,VPS25,NFE2,NBN,MEN1,TAF11 |
Interacting Protein
ID1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID1.
CAV1;CASK;APPL1;PSMD4;SUV39H1;TCF4;TCF3;COPB1;COL12A1;TCF3;PIAS1
Resources
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References
- Bordbar, B; Ndam, NT; et al. Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: Impact on vaccine design for placental malaria. INFECTION GENETICS AND EVOLUTION 25:81-92(2014).
- Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).
