IDH1
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Official Full Name
isocitrate dehydrogenase 1 (NADP+), soluble
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Overview
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. -
Synonyms
Cytosolic NADP isocitrate dehydrogenase; Cytosolic NADP-isocitrate dehydrogenase; ICDH; IDCD; IDH; IDH1; IDHC_HUMAN; IDP; IDPC; Isocitrate dehydrogenase [NADP] cytoplasmic; Isocitrate dehydrogenase 1 (NADP+) soluble; NADP dependent isocitrate dehydrogenase cytosolic; NADP dependent isocitrate dehydrogenase peroxisomal; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; PICD; Isocitrate dehydrogenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Human
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- C
- His
- DDK
- Flag
- His (Fc)
- Avi
- His|GST
- MYC
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- IDH1 Related Articles
- IDH1 Related Research Area
IDH1 involved in several pathways and played different roles in them. We selected most pathways IDH1 participated on our site, such as Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Citrate cycle (TCA cycle) | IDH2;MDH1;IDH3A;FH1;CS;PCK2;IDH3G;SUCLG1;PC |
Glutathione metabolism | GPX7;SMS;RRM2;G6PDX;MGST1.1;GSTA2;GPX5;GPX1A;GSTAL |
Metabolic pathways | NNMT;ETNK1;MT-ND1;MGAT5B;POLR3B;CHKA;UGP2A;ALDH5A1;IVD |
Carbon metabolism | FBP2;ACADS;PGAM1;PCXB;ackA;PDHA1B;PGK2;TPI1;GPT |
-Oxocarboxylic acid metabolism | ACO1;GPT2;ACY1;BCAT2;ACO2;GOT1;AADAT;GOT2A;BCAT1 |
Biosynthesis of amino acids | ALDOB;GOT2A;SDS;TPI1;ASL2;ARG2;PFKMA;ASS1;TALDO1 |
Peroxisome | NOS2;PEX19;DAO.2;AMACR;PEX10;ACSL4;SOD1;ACOX3;PEX12 |
Central carbon metabolism in cancer | GLS2;PIK3CG;PDK1;SIRT6;PIK3R1;PFKP;PDHB;PIK3R3;SLC7A5 |
IDH1 has several biochemical functions, for example, NAD binding, NADP binding, isocitrate dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH1 itself. We selected most functions IDH1 had, and list some proteins which have the same functions with IDH1. You can find most of the proteins on our site.
Function | Related Protein |
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NAD binding | GRHPRB;TESCA;ADH1;DLD;ME2;IDH3B;GPD1C;GPD1B;GPD1L |
NADP binding | HMGCRB;NOS1;FMO3;NOS3;ME1;G6PD;NOS2;POR;HMGCRA |
isocitrate dehydrogenase (NADP+) activity | IDH2;IDH1 |
magnesium ion binding | BPNT1;CIB2;HPRT1L;GTPBP5;RPS6KAL;PGM1;CDC42BPB;CDC42BPG;PSPH |
protein homodimerization activity | SNX9;ADRA2A;MCL1;KCNK3;ADRA2C;ASNSD1;C6orf108;MYH9;GPD1A |
receptor binding | CHRNA10;HFE;IDE;CD200;PTK2B;GDNF;CXADR;FGF11A;CSNK2B |
IDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH1.
gltX; mtfA; CEP57L1; ZHX1; 15-deoxy-delta(12,14; ere_dna
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