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IDH1

  • Official Full Name

    isocitrate dehydrogenase 1 (NADP+), soluble

  • Overview

    Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.
  • Synonyms

    Cytosolic NADP isocitrate dehydrogenase; Cytosolic NADP-isocitrate dehydrogenase; ICDH; IDCD; IDH; IDH1; IDHC_HUMAN; IDP; IDPC; Isocitrate dehydrogenase [NADP] cytoplasmic; Isocitrate dehydrogenase 1 (NADP+) soluble; NADP dependent isocitrate dehydrogenase cytosolic; NADP dependent isocitrate dehydrogenase peroxisomal; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; PICD; Isocitrate dehydrogenase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • DDK
  • Flag
  • His (Fc)
  • Avi
  • His|GST
  • MYC
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IDH1-1044H Active Recombinant Human IDH1 Protein, His-tagged E.coli His Met1-Leu414
Human IDH1-044H Active Recombinant Human IDH1 Protein, DDK-tagged Insect Cell DDK
Human IDH1-043H Active Recombinant Human IDH1 Protein, His-tagged Insect Cell His
Human IDH1-246H Recombinant Human IDH1 Mammalian Cell His
Human IDH1-2527H Recombinant Human IDH1 protein, His-tagged E.coli His Met1-Leu414
Human IDH1-1284H Recombinant Human Isocitrate Dehydrogenase 1 (NADP+), Soluble, His-tagged Human His
Human IDH1-111H Recombinant Human IDH1(R132C) Protein, His-tagged E.coli His 1-414
Human IDH1-112H Recombinant Human IDH1(R132H) Protein, His-tagged E.coli His 1-414
Human IDH1-14047H Recombinant Human IDH1, His-tagged E.coli His C-term-74a.a.
Human IDH1-114H Recombinant Human IDH1(Y139D) Protein, His-tagged E.coli His 1-414
Human IDH1-108H Recombinant Human IDH1(G97D) Protein, His-tagged E.coli His 1-414
Human IDH1-5849H Recombinant Human IDH1 protein, DDK-tagged Insect Cell DDK
Human IDH1-109H Recombinant Human IDH1(R100A) Protein, His-tagged E.coli His 1-414
Human IDH1-110H Recombinant Human IDH1(R100Q) Protein, His-tagged E.coli His 1-414
Human IDH1-042H Recombinant Human IDH1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IDH1-5307HCL Recombinant Human IDH1 293 Cell Lysate HEK293 N/A
Human IDH1-1134H Recombinant Human IDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IDH1-022H Recombinant Human IDH1 Protein, His-tagged E.coli His
Human IDH1-1116HFL Recombinant Full Length Human IDH1 Protein, C-Flag-tagged Mammalian cells Flag
Human IDH1-030H Recombinant Human IDH1 (R132H mutation) Protein, His-tagged E. coli His 2-414
Human IDH1-3401H Recombinant Human IDH1 Protein (Met1-Leu414), His tagged E.coli His Met1-Leu414
Human IDH1-023H Recombinant Human IDH1 Protein, His-tagged E.coli His 2-414
Human IDH1-0133H Recombinant Human IDH1 Protein (S2-L414), Tag Free E.coli No tag S2-L414
Human IDH1-0134H Recombinant Human IDH1 Protein (S2-L414), His tagged E.coli His S2-L414
Human IDH1-1134H-B Recombinant Human IDH1 Protein Pre-coupled Magnetic Beads HEK293
Human IDH1-029H Recombinant Human IDH1 Protein, His-tagged E. coli His
Human IDH1-5679HFL Recombinant Full Length Human IDH1 protein, Flag-tagged Mamanlian cells Flag
Human IDH1-13H Active Recombinant Human IDH1 Protein (1-414aa), N-His tagged E.coli N-His 1-414 aa
Human IDH1-3029H Recombinant Human IDH1 Protein(1-414aa), His-tagged E. coli C-His 1-414aa
Mouse IDH1-7984M Recombinant Mouse IDH1 Protein Mammalian Cell His
Mouse IDH1-4409M-B Recombinant Mouse IDH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse IDH1-565M Recombinant Mouse IDH1 Protein (7-407 aa), His-tagged E.coli His 7-407 aa
Mouse IDH1-4409M Recombinant Mouse IDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Idh1-1212M Recombinant Mouse Idh1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Idh1-1583M Recombinant Mouse Idh1 protein, His & GST-tagged E.coli His/GST Ile99~Thr325 (Accession # O88844)
Rat IDH1-2985R Recombinant Rat IDH1 Protein Mammalian Cell His
Rat Idh1-1584R Recombinant Rat Idh1 protein, His-tagged E.coli His Pro78~Ile330 (Accession # P41562)
Rat IDH1-2640R Recombinant Rat IDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IDH1-2640R-B Recombinant Rat IDH1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IDH1-2191R Recombinant Rhesus monkey IDH1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IDH1-2012R Recombinant Rhesus Macaque IDH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IDH1-2012R-B Recombinant Rhesus Macaque IDH1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IDH1-11544Z Recombinant Zebrafish IDH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IDH1 Related Articles
  • IDH1 Related Research Area

IDH1 involved in several pathways and played different roles in them. We selected most pathways IDH1 participated on our site, such as Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)IDH2;MDH1;IDH3A;FH1;CS;PCK2;IDH3G;SUCLG1;PC
Glutathione metabolismGPX7;SMS;RRM2;G6PDX;MGST1.1;GSTA2;GPX5;GPX1A;GSTAL
Metabolic pathwaysNNMT;ETNK1;MT-ND1;MGAT5B;POLR3B;CHKA;UGP2A;ALDH5A1;IVD
Carbon metabolismFBP2;ACADS;PGAM1;PCXB;ackA;PDHA1B;PGK2;TPI1;GPT
-Oxocarboxylic acid metabolismACO1;GPT2;ACY1;BCAT2;ACO2;GOT1;AADAT;GOT2A;BCAT1
Biosynthesis of amino acidsALDOB;GOT2A;SDS;TPI1;ASL2;ARG2;PFKMA;ASS1;TALDO1
PeroxisomeNOS2;PEX19;DAO.2;AMACR;PEX10;ACSL4;SOD1;ACOX3;PEX12
Central carbon metabolism in cancerGLS2;PIK3CG;PDK1;SIRT6;PIK3R1;PFKP;PDHB;PIK3R3;SLC7A5

IDH1 has several biochemical functions, for example, NAD binding, NADP binding, isocitrate dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH1 itself. We selected most functions IDH1 had, and list some proteins which have the same functions with IDH1. You can find most of the proteins on our site.

Function Related Protein
NAD bindingGRHPRB;TESCA;ADH1;DLD;ME2;IDH3B;GPD1C;GPD1B;GPD1L
NADP bindingHMGCRB;NOS1;FMO3;NOS3;ME1;G6PD;NOS2;POR;HMGCRA
isocitrate dehydrogenase (NADP+) activityIDH2;IDH1
magnesium ion bindingBPNT1;CIB2;HPRT1L;GTPBP5;RPS6KAL;PGM1;CDC42BPB;CDC42BPG;PSPH
protein homodimerization activitySNX9;ADRA2A;MCL1;KCNK3;ADRA2C;ASNSD1;C6orf108;MYH9;GPD1A
receptor bindingCHRNA10;HFE;IDE;CD200;PTK2B;GDNF;CXADR;FGF11A;CSNK2B

IDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH1.

gltX; mtfA; CEP57L1; ZHX1; 15-deoxy-delta(12,14; ere_dna

Bunse, L; Schumacher, T; et al. Proximity ligation assay evaluates IDH1(R132H) presentation in gliomas. JOURNAL OF CLINICAL INVESTIGATION 125:593-606(2015).
Kawasoe, T; Takeshima, H; et al. Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. JOURNAL OF NEUROSURGERY 122:317-323(2015).
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