• Official Full Name

    immunoglobulin superfamily, member 8

  • Overview

    This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
  • Synonyms

    IGSF8; immunoglobulin superfamily, member 8; EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1; immunoglobulin superfamily member 8; CD81 partner 3; prostaglandin regulatory-like protein; glu-Trp-Ile EWI motif-containing protein 2; keratinocytes-associated transmembrane protein 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGSF8-29100TH Recombinant Human IGSF8, His-tagged E.coli His
Human IGSF8-14128H Recombinant Human IGSF8, His-tagged E.coli His
Human IGSF8-500H Recombinant Human IGSF8 Protein, His-tagged HEK293 His
Human IGSF8-312H Recombinant Human IGSF8, His tagged Human Cell Fc
Human IGSF8-977HCL Recombinant Human IGSF8 cell lysate Human Cell N/A
Human IGSF8-5321H Recombinant Human IGSF8 Protein (Met1-Thr579), C-His tagged Mammalian cells C-His
Human IGSF8-2919H Recombinant Human IGSF8 Protein (Arg28-Thr579), C-His tagged Mammalian cells C-His
Human IGSF8-311H Recombinant Human IGSF8(Arg28-Thr579) Protein, C-Fc-tagged HEK293 Fc
Mouse IGSF8-953M Recombinant Mouse IGSF8 Protein, Fc-tagged HEK293 Fc
Mouse Igsf8-8697M Recombinant Mouse Igsf8, His tagged Human Cell His
Mouse IGSF8-1378MCL Recombinant Mouse IGSF8 cell lysate Human Cell N/A
Cynomolgus Monkey IGFBP5-151C Recombinant Cynomolgus IGSF8, His tagged Human Cell His
Zebrafish IGSF8-11826Z Recombinant Zebrafish IGSF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGSF8 Related Articles
  • IGSF8 Related Research Area

IGSF8 involved in several pathways and played different roles in them. We selected most pathways IGSF8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IGSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

IGSF8 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGSF8 itself. We selected most functions IGSF8 had, and list some proteins which have the same functions with IGSF8. You can find most of the proteins on our site.

Function Related Protein
protein bindingTHAP11;BARD1;EPB41B;RAB39B;MAL2;KIF2C;RPP25;CXXC5;PDZK1

IGSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGSF8.

KRTAP10-4; KRTAP10-7; KRTAP10-8; KRTAP10-9; CD9

Rappa, G; Green, TM; et al. The Nuclear Pool of Tetraspanin CD9 Contributes to Mitotic Processes in Human Breast Carcinoma. MOLECULAR CANCER RESEARCH 12:1840-1850(2014).
Glazar, AI; Evans, JP; et al. Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. REPRODUCTION FERTILITY AND DEVELOPMENT 21:293-303(2009).
Murdoch, JN; Doudney, K; et al. Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. MOLECULAR AND CELLULAR NEUROSCIENCE 22:62-74(2003).
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