Ihh

Official Full Name

indian hedgehog
Overview

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
Synonyms

IHH; indian hedgehog; BDA1; HHG2; indian hedgehog protein; HHG-2; Indian hedgehog homolog;

Type

Recombinant Proteins

Species

Chicken
Human
Human/Mouse
Mouse

Source

E.coli
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IHH-7884H	Recombinant Human IHH protein, His-tagged	E.coli	His	Phe240~Gly399	Inquiry
Human	IHH-656H	Recombinant Human IHH protein	E.coli	Non	176	Inquiry
Human	IHH-1673H	Recombinant Human IHH protein, His & T7-tagged	E.coli	His&T7	Val45~Ser195	Inquiry
Human	IHH-372I	Active Recombinant Human IHH Protein (178 aa)	E.coli		178	Inquiry
Human	IHH-3104H	Recombinant Human IHH Protein (Phe240-Gly399), His tagged	E.coli	His	Phe240-Gly399	Inquiry
Human	IHH-4428H	Recombinant Human IHH protein, His-tagged	E.coli	His	203-411aa	Inquiry
Mouse	Ihh-1892M	Active Recombinant Mouse Indian Hedgehog	E.coli	Non	Cys28-Gly202	Inquiry
Human/Mouse	IHH-124H	Recombinant Human/Mouse IHH Protein	E.coli			Inquiry
Human/Mouse	IHH-125H	Recombinant Human/Mouse IHH Protein	E.coli			Inquiry
Human/Mouse	IHH-126H	Recombinant Human/Mouse IHH Protein	E.coli			Inquiry
Chicken	IHH-6516C	Recombinant Chicken IHH	Mammalian Cell	His		Inquiry
Chicken	IHH-433C	Recombinant Chicken IHH protein, His&Myc-tagged	E.coli	His&Myc	24-408a.a.	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

Ihh involved in several pathways and played different roles in them. We selected most pathways Ihh participated on our site, such as Hedgehog signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ihh were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hedgehog signaling pathway	CSNK1DA;WNT7A;BMP4;IHHA;PRKACG;BMP2;WNT16;DHH;WNT8A

Ihh has several biochemical functions, for example, calcium ion binding, patched binding, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ihh itself. We selected most functions Ihh had, and list some proteins which have the same functions with Ihh. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PCDH18B;ARSA;CGREF1;ACTN3A;ITIH1;DOC2B;PPEF2;ENPP2;KCNIP4
patched binding	SMO;IHH;Shh;BBS1;CCNB1;SETD6;PTCH1;CAV1;DHH
peptidase activity	CAPN11;CAPN3B;CTSM;OVCH2;F2RL1.2;CTSL.1;DUB1;GZME;ADAM25

Ihh has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ihh here. Most of them are supplied by our site. Hope this information will be useful for your research of Ihh.

RHOD

Research Area

Hedgehogs

Other Cytokines & Receptors

Kebenko, M; Drenckhan, A; et al. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. CELLULAR SIGNALLING 27:373-381(2015).

Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).