ikzf1
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  • Official Full Name
  • IKAROS family zinc finger 1
  • Background
  • Ikaros functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyltransferase promoter as well as with the promoters for other genes expressed during early stages of B and T cell development.
  • Synonyms
  • IKZF1; IKAROS family zinc finger 1; DNA-binding protein Ikaros; ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein subfamily 1A, 1; zinc finger protein, subfamily 1A, 1 (Ikaros); LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik; KIAA4227
Cat.#:IKZF1-125HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKZF1 protein, MYC/DDK-tagged
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Cat.#:IKZF1-182HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKZF1 protein, T7/His-tagged
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Cat.#:IKZF1-6645CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKZF1
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Cat.#:IKZF1-8622ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IKZF1
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Cat.#:IKZF1-850HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IKZF1 cell lysate
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Involved Pathway

IKZF1 involved in several pathways and played different roles in them. We selected most pathways IKZF1 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
CSF2; JUNB; DGKA; EGR2; CTLA4; POU2F1; EGR4; CDK4; IRF4; EGR3

Protein Function

IKZF1 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF1 itself. We selected most functions IKZF1 had, and list some proteins which have the same functions with IKZF1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TERT; NR5A1; NKX2.4A; ZNF526; SSRP1A; ZBTB22; IRX1A; HIST1H3A; HOXA11A; ARID1A
Function metal ion binding
Related Protein TP63; ZNF460; YOD1; ZNF395; SMAD7; ZNF740B; ITGAM; TRIM41; ATP13A5; THRAA
Function protein binding
Related Protein NEBL; C3orf62; CLK3; C14orf169; PPP2R1B; NAPG; LSM11; PLIN1; TOMM70A; ALDH1A2
Function protein heterodimerization activity
Related Protein NPM1; PPP1CBL; EXT1; SYT5; TLX1; HIST1H2B8; TLR2; HIST1H2BL; GABPA; DMRTA2
Function sequence-specific DNA binding
Related Protein MAFK; PPARDB; SALL3; RX2; DMRT2; FOXD5; ZSCAN16; HOXA7; ELF2B; TFCP2L1
Function transcription factor activity, sequence-specific DNA binding
Related Protein HOXB5A; DMRTA2; SALL1; TCF7L2; ZNF561; EFCAB11; TBX3A; SOX5; MNX1; SLC12A9
Function transcription regulatory region DNA binding
Related Protein TAL1; SNCA; MSX2; ATF5; BRD7; NKX2; RELA; PPARG; MEN1; SERPINB1A

Interacting Protein

IKZF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF1.
DCX; RAD51D; CTBP2; RWDD2B; FAM214B