IKZF1

Official Full Name

IKAROS family zinc finger 1
Overview

Ikaros functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyltransferase promoter as well as with the promoters for other genes expressed during early stages of B and T cell development.
Synonyms

IKZF1; IKAROS family zinc finger 1; DNA-binding protein Ikaros; ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; zinc finger protein subfamily 1A, 1; zinc finger protein, subfamily 1A, 1 (Ikaros); LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik; KIAA4227;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mamanlian cells
Mammalian Cell
Mammalian cells

Tag

Flag
His
Avi
T7
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IKZF1-182H	Recombinant Human IKZF1 protein, T7/His-tagged	E.coli	His&T7		Inquiry
Human	IKZF1-125H	Recombinant Human IKZF1 protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	IKZF1-850HCL	Recombinant Human IKZF1 cell lysate		Non		Inquiry
Human	IKZF1-2552H	Recombinant Human IKZF1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	IKZF1-4416H	Recombinant Human IKZF1 protein, His-Avi-tagged	E.coli	His&Avi	1-477aa	Inquiry
Human	IKZF1-9822HFL	Recombinant Full Length Human IKZF1 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	IKZF1-3889H	Recombinant Human IKZF1 Protein (Met1-Ser519), C-MYC/DDK tagged	Mammalian cells	Myc&DDK	Met1-Ser519	Inquiry
Mouse	Ikzf1-3498M	Recombinant Mouse Ikzf1 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Zebrafish	IKZF1-8622Z	Recombinant Zebrafish IKZF1	Mammalian Cell	His		Inquiry
Chicken	IKZF1-6645C	Recombinant Chicken IKZF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

IKZF1 involved in several pathways and played different roles in them. We selected most pathways IKZF1 participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	BATF3;JUNB;EGR2;CTLA4;IKZF1;CSF2;EGR1;POU2F1;DGKA

IKZF1 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF1 itself. We selected most functions IKZF1 had, and list some proteins which have the same functions with IKZF1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	Trl;PPP1R10;IRF1B;KDM5C;NR5A1A;AHR2;NKX3.2;CERS5;ARID3C
metal ion binding	ILKAP;ZFP354A;PDE11A;ZNRF2A;ACVR2AA;ZBTB7C;FOXP1;ZNHIT3;TRMT1L
protein binding	S100A16;SH2D1A;STARD10;AHNAK2;SPINLW1;KCTD17;LILRA4;TOR1B;PTPRG
protein heterodimerization activity	MID1;HIST1H4E;GTF2A2;H2-AA;ZFP423;NR2C2;USF2;DMRT3A;HIST1H4H
sequence-specific DNA binding	CALCOCO1;PRRXL1;RXRAA;ISL2;SIX2B;NEUROG2;NR1D2A;SOX2;LHX2B
transcription factor activity, sequence-specific DNA binding	FOXP1A;ZNF565;PA2G4;TFAP2B;TBX1;FOXO3A;USF2;RBPJL;SOX11B
transcription regulatory region DNA binding	TBL1XR1;ZNF567;NR1H3;TBX21;KCNA3;YAP1;AIRE;RCOR1;KLF11

IKZF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF1.

DCX; RAD51D; CTBP2; RWDD2B; FAM214B