IL17RB
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Official Full Name
interleukin 17 receptor B
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Overview
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008] -
Synonyms
IL17RB; interleukin 17 receptor B; CRL4; EVI27; IL17BR; IL17RH1; interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus
- Rhesus Macaque
- E.coli
- HEK293
- Human Cell
- Insect Cell
- Mammalian cells
- C
- His
- Fc
- FLAG
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL17RB involved in several pathways and played different roles in them. We selected most pathways IL17RB participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | GDF5;BMP7;CCR8L;TNFSF13B;CCR8;XCR1;CCL4;IL17B;CCL21B |
IL17RB has several biochemical functions, for example, cytokine receptor activity, interleukin-17 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17RB itself. We selected most functions IL17RB had, and list some proteins which have the same functions with IL17RB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | IL12RB2;IL31RA;CRFB16;IL11RA;FLT3;F3B;LIFRA;CSF3R;IL12RB1 |
| interleukin-17 receptor activity | IL17RC;IL17RE;IL17RB;IL17RA;IL17RD |
IL17RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17RB here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17RB.
RPS6KA5; hasR
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewHigh stability.
Good for flow cytometry.
Potent in anti-viral assays.
Q&As (10)
Ask a questionAnimal models, flow cytometry, and tissue-specific knockout strategies uncover IL17RB's involvement in inflammation and cell recruitment.
CRISPR/Cas9, siRNA, and gene editing techniques manipulate IL17RB to investigate its role in autoimmune disease pathogenesis.
Biomarker analysis, patient stratification, and clinical correlation studies investigate IL17RB's association with disease severity.
Co-receptor binding assays, protein-protein interaction studies, and functional rescue experiments reveal IL17RB's interaction partners.
In vitro wound healing assays, fibroblast activation studies, and tissue regeneration models probe IL17RB's contribution to tissue repair.
Blocking antibodies, receptor activation assays, and cytokine profiling reveal IL17RB's impact on immune responses.
Animal models, therapeutic antibody studies, and safety assessments evaluate IL17RB-targeted therapies and clinical translation challenges.
Surface plasmon resonance, ELISA, and competitive binding assays determine IL17RB's affinity for various IL17 family members.
Tumor xenograft models, immune cell infiltration assays, and gene expression analysis explore IL17RB's role in cancer biology.
Phosphorylation assays, gene expression profiling, and co-immunoprecipitation studies elucidate IL17RB-mediated signaling networks.
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