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Recombinant Human IL17RB Protein, His-tagged

Cat.No. : IL17RB-2295H
Product Overview : Recombinant Human IL17RB Protein (Asp61-Thr200) with a N-His tag was expressed in E. coli.
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  • Gene Information
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Description : The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Source : E. coli
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 19.4 kDa
Accurate Molecular Mass: 19 kDa
Protein length : Asp61-Thr200
Endotoxin : <1.0 EU per 1µg (determined by the LAL method).
Purity : > 80%
Applications : Cell culture; Activity Assays.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : IL17RB interleukin 17 receptor B [ Homo sapiens (human) ]
Official Symbol : IL17RB
Synonyms : IL17RB; interleukin 17 receptor B; IL17BR, interleukin 17B receptor; interleukin-17 receptor B; CRL4; EVI27; IL17RH1; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1; IL17BR; MGC5245;
Gene ID : 55540
mRNA Refseq : NM_018725
Protein Refseq : NP_061195
MIM : 605458
UniProt ID : Q9NRM6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can you elaborate on the techniques employed to study the role of IL17RB in tissue-specific inflammation and immune cell recruitment? 11/17/2021

Animal models, flow cytometry, and tissue-specific knockout strategies uncover IL17RB's involvement in inflammation and cell recruitment.

How do researchers manipulate IL17RB expression and function in cellular and animal models to understand its contribution to autoimmune diseases? 07/10/2021

CRISPR/Cas9, siRNA, and gene editing techniques manipulate IL17RB to investigate its role in autoimmune disease pathogenesis.

Could you explain how patient samples and clinical data are utilized to investigate the correlation between IL17RB expression and disease severity in various inflammatory disorders? 01/06/2020

Biomarker analysis, patient stratification, and clinical correlation studies investigate IL17RB's association with disease severity.

What molecular and cellular assays are employed to explore the interaction between IL17RB and other immune receptors or cytokines? 09/15/2019

Co-receptor binding assays, protein-protein interaction studies, and functional rescue experiments reveal IL17RB's interaction partners.

What experimental strategies are used to dissect the involvement of IL17RB in tissue repair processes, such as wound healing and fibrosis? 05/23/2019

In vitro wound healing assays, fibroblast activation studies, and tissue regeneration models probe IL17RB's contribution to tissue repair.

What techniques are used to study the impact of IL17RB inhibition or activation on immune responses and inflammation in experimental settings? 07/29/2018

Blocking antibodies, receptor activation assays, and cytokine profiling reveal IL17RB's impact on immune responses.

How is the potential of IL17RB as a therapeutic target evaluated in preclinical studies, and what challenges exist in translating these findings into clinical applications? 12/31/2017

Animal models, therapeutic antibody studies, and safety assessments evaluate IL17RB-targeted therapies and clinical translation challenges.

How is the ligand binding affinity of IL17RB to different IL17 family members determined experimentally? 12/02/2017

Surface plasmon resonance, ELISA, and competitive binding assays determine IL17RB's affinity for various IL17 family members.

How do researchers investigate the role of IL17RB in cancer and tumor microenvironment modulation, and what experimental models are commonly used? 08/23/2017

Tumor xenograft models, immune cell infiltration assays, and gene expression analysis explore IL17RB's role in cancer biology.

What experimental methods are used to investigate the downstream signaling pathways activated by IL17RB, and how are these pathways integrated with other immune responses? 04/18/2017

Phosphorylation assays, gene expression profiling, and co-immunoprecipitation studies elucidate IL17RB-mediated signaling networks.

Customer Reviews (3)

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Reviews
10/07/2022

    High stability.

    06/23/2022

      Good for flow cytometry.

      05/20/2017

        Potent in anti-viral assays.

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