Il20
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Official Full Name
interleukin 20
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Background
Human IL-20 or Interleukin-20, also known as Cytokine Zcyto10, is a 176 amino acid cytokine protein expressed from the IL20 gene located at locus 1q32 on chromosome 1. After initial synthesis of the protein, it undergoes proteolytic cleavage where the 24 residue signal sequence is cleaved, allowing for the proper folding and maturation of the IL-20 cytokine. Recent studies have determined that IL-20, belonging to the IL-10 family, may be involved in epidermal function and psoriasis via signal transduction through Signal Transducer and Activator of Transcription 3 (STAT3) in keratinocytes. It is expressed at very low levels in skin, trachea and other tissues. -
Synonyms
UNQ852/PRO1801; IL-20; IL10D; ZCYTO10; cytokine Zcyto10; four alpha helix cytokine; interleukin-20;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il20 Related Gene Family
- Il20 Related Research Area
Il20 involved in several pathways and played different roles in them. We selected most pathways Il20 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF25;IFNA1;OSTN;IL11;CCL24;Ifna11;IL17RB;CXCL8;CCL19 |
| Jak-STAT signaling pathway | LEPR;M17;AKT2;PIK3R3A;CRLF2;PIK3R2;IL10RA;IRX1;PIAS4A |
Il20 has several biochemical functions, for example, cytokine activity, interleukin-20 receptor binding, interleukin-22 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il20 itself. We selected most functions Il20 had, and list some proteins which have the same functions with Il20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | WNT5A;GPI1;CCL4;GDF11;C1QTNF4;BMP5;GM13288;IL17B;ILTIFB |
| interleukin-20 receptor binding | |
| interleukin-22 receptor binding | IL20;IL22 |
Il20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il20 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il20.
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