Recombinant Active Human IL20 Protein, His-tagged(C-ter)

Cat.No. : IL20-172H
Product Overview : Recombinant Active Human IL20 Protein with His tag (C-ter) was expressed in E. coli.
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Description : The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Source : E. coli
Species : Human
Tag : His(C-ter)
Form : Powder
Bio-activity : Determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with human IL-20R alpha and IL-20R beta. The ED50 for this effect is < 0.2 ng/mL.
AA Sequence : MLKTLNLGSCVIATNLQEIRNGFSE IRGSVQAKDGNIDIRILRRTESLQD TKPANRCCLLRHLLRLYLDRVFKNY QTPDHYTLRKISSLANSFLTIKKDL RLCHAHMTCHCGEEAMKKYSQILSH FEKLEPQAAVVKALGELDILLQWME ETE
Endotoxin : Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
Purity : > 98% (by SDS-PAGE)
Applications : SDS-PAGE
Notes : For laboratory research only, not for drug, diagnostic or other use.
Storage : Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Storage Buffer : PBS (pH 8.0)
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.
SDS-PAGE:
Gene Name : IL20 interleukin 20 [ Homo sapiens ]
Official Symbol : IL20
Synonyms : IL20; interleukin 20; interleukin-20; IL 20; IL10D; ZCYTO10; cytokine Zcyto10; four alpha helix cytokine; IL-20; MGC96907;
Gene ID : 50604
mRNA Refseq : NM_018724
Protein Refseq : NP_061194
MIM : 605619
UniProt ID : Q9NYY1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does IL-20 influence tissue repair and regeneration? 03/20/2022

IL-20 has been implicated in tissue repair processes, and harnessing its properties may have implications for regenerative medicine.

How is IL-20 protein clinically applied in treating autoimmune diseases? 01/12/2022

IL-20 is being explored as a potential therapeutic target in autoimmune diseases due to its involvement in immune system regulation.

In what ways does IL-20 contribute to inflammatory responses? 08/01/2020

IL-20 is known to promote inflammation, and understanding its mechanisms may lead to targeted anti-inflammatory therapies.

Are there any ongoing clinical trials involving IL-20 protein? 03/21/2019

Yes, there are several clinical trials exploring the safety and efficacy of IL-20 inhibitors in various disease contexts.

Can IL-20 be a target for personalized medicine in autoimmune conditions? 01/17/2016

Tailoring treatments based on individual IL-20 levels and responses is a potential avenue for personalized medicine.

Customer Reviews (3)

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Reviews
04/14/2023

    The reliability and reproducibility of the IL20 Protein's performance make it a go-to option for WB experiments.

    12/13/2022

      The IL20 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.

      06/25/2021

        By utilizing the IL20 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.

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