IRAK1 Protein


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Official Full Name interleukin-1 receptor-associated kinase 1
Background Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
Synonyms IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    • N-GST and C-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRAK1-1542H Recombinant Human IRAK1, His-tagged E.coli His
    Human IRAK1-27500TH Recombinant Human IRAK1 Wheat Germ N/A
    Human IRAK1-27502TH Recombinant Human IRAK1 Wheat Germ N/A
    Human IRAK1-5436H Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged Insect Cell GST
    Human IRAK1-7068H Recombinant Human IRAK1 protein, His-tagged E.coli His
    Human IRAK1-5173HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
    Human IRAK1-5174HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
    Human IRAK1-01H Recombinant Human IRAK1 Protein, GST-tagged Insect Cell GST
    Human IRAK1-1200H Recombinant Human IRAK1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IRAK1-257HF Recombinant Full Length Human IRAK1 Protein In Vitro Cell Free System
    Human IRAK1-5726HF Recombinant Full Length Human IRAK1 Protein, GST-tagged In Vitro Cell Free System GST
    Human IRAK1-799H Recombinant Human IRAK1 Protein, GST/His-tagged E.coli N-GST and C-His
    Human IRAK1-2103H Recombinant Human IRAK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IRAK1-5056H Recombinant Human IRAK1 Protein, GST-tagged Wheat Germ GST
    Human IRAK1-869H Recombinant Human IRAK1 protein, His-tagged Insect cell His
    Mouse Irak1-1243M Recombinant Mouse Irak1 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    IRAK1 involved in several pathways and played different roles in them. We selected most pathways IRAK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway LYN; LTA; BCL2A1A; ICAM1; CD40LG; LAT; TRAF2; CXCL2; XIAP; BTK
    Toll-like receptor signaling pathway MAPK8A; Ifna11; PIK3R2; IFNA6; TLR2; IFNA1; MAPK3; CD40; TLR7; CXCL8B.3
    Neurotrophin signaling pathway MAPK3; SH2B3; NGFR; PIK3CD; PSEN1; SHC1; RIPK2; NTF3; NTRK2; FASLG
    Pertussis PYCARD; GM5077; IRF1; Il23a; Il12b; RHOA; CALM3; ITGB2L; IL12B; MAPK10; TRAF6
    Leishmaniasis IL4; IFNG; IRAK4; FCGR2A; IL12A; FCGR3; MAPK12; ITGB2L; HLA-DMA; TLR4
    Chagas disease (American trypanosomiasis) CCL5; PIK3R3; IL1B2; CCL3L3; PLCB3; PIK3CD; TNF; PLCB4; IL-8; MAPK8
    Toxoplasmosis NFKBIA; TLR4; HLA-DRB4; HSPA2; IKBKG; HLA-DPB1; TLR2; MAPK12; PIK3R1; HSPA1A
    Tuberculosis IFNA17; H2-AB1; Il23a; Il12b; ITGAM; ITGAX; RAB7; CORO1A; CAMP; CASP10; LAMP2
    Measles MAVS; SH2D1A; STAT2; PIK3CG; TRAF6; CD46; MYD88; IL2RA; HSPA1L; EIF2AK1
    Epstein-Barr virus infection YWHAH; YWHAE; NUP214; PIK3R3; SNW1; TRP53; HSPA6; TNFAIP3; PSMD4; PIK3CG

    IRAK1 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK1 itself. We selected most functions IRAK1 had, and list some proteins which have the same functions with IRAK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DCLK1; TOR1L3; TSSK6; CCT8; ACSF3; P2RX3A; TNK2; KALRN; UBE2E1; PAK7
    NF-kappaB-inducing kinase activity RIPK3; IRAK1; MAP3K14; ALPK2; PPP4C; ALK; IKBKE
    heat shock protein binding EEF1D; LMAN2; HSPA6; DNAJC7; PPP5C; FKBP4; DAXX; CDC37L1; HSPA8; NFKB1
    interleukin-1 receptor binding TLR9; Il1f6; IRAK4; IL1RN; IL36G; TRIP6; IL1F10; TLR5; IL36RN; IL37
    kinase activity GM7168; ACVR1BA; TRIOA; TRIO; STK24B; PRKAB1B; NME2B.1; GRK7A; CAMK2A; AKT1
    protein binding MOXD1; SIN3A; GPR177; JAKMIP1; SYTL1; ALDH18A1; UTP23; MTUS2; SERP2; FMO4
    protein heterodimerization activity DDX1; USF1; RELA; ATF2; Defa-rs7; TFAP2B; HIST1H2AC; TENM1; HIST2H2L; MCL1A
    protein homodimerization activity FBXO4; JAM3; APOA4; TRIM37; Pdgfa&Pdgfb; CARD9; MAP3K9; LRRK2; GSTM1; GREM2
    protein kinase activity MAP3K14; SLKA; PLK5; CSNK1G2B; PIK3C3; GM4922; MKNK2B; PAN3; PRKCHB; MAPKAPK2B
    protein serine/threonine kinase activity CSNK1G2; DCLK1A; ULK1A; PRKCHB; TLK2; PKZ; SMOK2B; MAP2K4; CHEK2; CSNK1DA
    ubiquitin-protein transferase activity PDZRN3B; BIRC5B; RNF20; ANKIB1A; G2E3; FBXO25; LTN1; CNOT4; RAG1; SHPRH

    IRAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK1.

    TRAF6; PELI2; PIN1; MYD88; PELI1

    Zhang, JM; Jia, G; et al. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis. IMMUNOLOGY 144:56-67(2015).
    Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).

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