IRAK1

  • Official Full Name

    interleukin-1 receptor-associated kinase 1

  • Overview

    Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
  • Synonyms

    IRAK1; interleukin-1 receptor-associated kinase 1; IRAK; pelle; IRAK-1; Pelle homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • C
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRAK1-1542H Recombinant Human IRAK1 Protein, His tagged E.coli N-His
Human IRAK1-27500TH Recombinant Human IRAK1 Wheat Germ N/A
Human IRAK1-7068H Recombinant Human IRAK1 protein, His-tagged E.coli His
Human IRAK1-5436H Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged Insect Cell GST
Human IRAK1-27502TH Recombinant Human IRAK1 Wheat Germ N/A
Human IRAK1-5173HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
Human IRAK1-5174HCL Recombinant Human IRAK1 293 Cell Lysate HEK293 N/A
Human IRAK1-869H Recombinant Human IRAK1 protein, His-tagged Insect cell His
Human IRAK1-1200H Recombinant Human IRAK1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human IRAK1-2103H Recombinant Human IRAK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRAK1-5056H Recombinant Human IRAK1 Protein, GST-tagged Wheat Germ GST
Human IRAK1-1171H Recombinant Human IRAK1 Protein (R194-S712), GST tagged Insect Cell GST
Human IRAK1-5726HF Recombinant Full Length Human IRAK1 Protein, GST-tagged In Vitro Cell Free System GST
Human IRAK1-799H Recombinant Human IRAK1 Protein, GST/His-tagged E.coli N-GST and C-His
Human IRAK1-257HF Recombinant Full Length Human IRAK1 Protein In Vitro Cell Free System
Human IRAK1-01H Active Recombinant Human IRAK1 Protein, GST-tagged Insect Cell GST
Human IRAK1-1170H Recombinant Human IRAK1 Protein (R194-S712), Tag Free Insect Cell No tag
Human IRAK1-2647H Recombinant Human IRAK1 Protein (Phe212-Leu434), N-His tagged E.coli N-His
Mouse Irak1-1243M Recombinant Mouse Irak1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRAK1 Related Articles
  • IRAK1 Related Signal Pathway

IRAK1 involved in several pathways and played different roles in them. We selected most pathways IRAK1 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayTNF;NFKBIA;Ccl21c;RELB;CD14;CCL19;TNFSF11;CARD11;GM1987
ApoptosisPRKAR2B;CASP3A;AKT2;IRAK1;BNIP3LB;PIK3R3B;PRKACG;Fasl;IL1B
Toll-like receptor signaling pathwayPIK3CD;PIK3R1;LBP;TLR2-1;TLR4;CXCL10;RAC1A;PIK3R3;AKT2L
Neurotrophin signaling pathwayNFKBIA;AKT1;HRAS;MAP2K2;BRAF;MAP3K1;RIPK2;GSK3B;SH2B2
PertussisC2;CALM3;ITGA5;GNAI2;IRAK1;CASP7;C1QB;C1S;MAPK11
LeishmaniasisIFNG;HLA-DRB4;FCGR1;HLA-DRB3;IRAK4;HLA-DOA;NCF1;IRAK1;MYD88
Chagas disease (American trypanosomiasis)MAPK12;MAPK9;MAPK13;PIK3CB;TLR2;PIK3R3;NOS2;Il2;MAP2K4
ToxoplasmosisMAP2K3;HLA-DQA1;BIRC2;IL12A;Toxoplasma Gondii Major Surface Antigen P30;IKBKG;TYK2;IL12B;IL10RA
TuberculosisATP6V0A4;CAMP;IFNA13;IFNA14;RFX5;PPP3R1;CLEC4E;RFXAP;FCGR3B
MeaslesMSN;TNFRSF10D;Cd209g;IRF3;Fasl;TLR4;STAT3;IFNA4;TNFAIP3
Epstein-Barr virus infectionPOLR3B;PSMD12;EIF2AK2;RBPJL;CCNA1;SKP2;POLR3E;PLCG1;NFKBIE

IRAK1 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK1 itself. We selected most functions IRAK1 had, and list some proteins which have the same functions with IRAK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEPHA7;NADKD1;PSKH1;MYO6B;EK1;NLK1;CDK14;UBE2G1B;TTN
NF-kappaB-inducing kinase activityALK;MAP3K14;IKBKE;RIPK3;IRAK1;ALPK2;PPP4C
heat shock protein bindingBAK1;GRXCR2;APAF1;KCNJ11;DNAJA2;PDXP;DNAJA3;IRAK1;FAF1
interleukin-1 receptor bindingIL36RN;IL1RN;IL37;TLR9;IL1F10;IRAK4;IRAK1;IL36B;Il1f6
kinase activityMOB1BA;NUCKS1A;CKMT2A;CAMK2B1;DNAJC3B;FGGY;GUK1B;CKMB;CDC7
protein bindingE2F3;KIRREL3;PWWP2B;GTPBP3;ZNF350;RARG;POLH;RCOR3;ALX1
protein heterodimerization activityBMP6;DDIT3;EXT2;H2AFJ;HIST2H2L;DMBX1;MYOG;TAF8;SYT14
protein homodimerization activityTIMELESS;DMRTB1;MAFA;PON1;TREX2;C16orf89;TBX18;RAG1;PVRL1A
protein kinase activityPRKCHA;MAP4K6;BMPR1AB;CDK11A;GRK1;TBRG4;TRIM28;NTRK3A;SRPK1B
protein serine/threonine kinase activitySLC14A2;BMPR1BA;SGK3;ULK1;LATS1;MYLK4;SLKA;ACVR1B;NEK11
ubiquitin-protein transferase activityUBE2R2;KLHL20;MUL1B;FEM1B;CDC34;RBCK1;HECTD3;BRCA1;RAG1

IRAK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK1.

TRAF6; PELI2; PIN1; MYD88; PELI1

Zhang, JM; Jia, G; et al. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis. IMMUNOLOGY 144:56-67(2015).
Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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Are there any ongoing clinical trials targeting IRAK1 for cancer treatment? 03/16/2023

Yes, there are several clinical trials exploring the inhibition of IRAK1 as a therapeutic strategy for various types of cancer.

How is IRAK1 protein implicated in autoimmune diseases? 06/19/2020

IRAK1 is involved in the signaling pathways that can lead to the development of autoimmune diseases by regulating the immune system's response to self-antigens.

How does the expression of IRAK1 relate to inflammatory diseases? 01/08/2020

Elevated levels of IRAK1 expression have been observed in inflammatory diseases, suggesting its involvement in the dysregulation of inflammatory responses.

In what ways can IRAK1 be a target for drug development in inflammatory conditions? 08/23/2016

Inhibiting IRAK1 activity is being investigated as a potential therapeutic approach for managing inflammatory conditions, offering a target for drug development.

What clinical significance does IRAK1 hold in cancer research? 03/31/2016

IRAK1 has been identified as a potential target for cancer therapy, as it plays a role in promoting tumor growth and evasion of the immune system.

Customer Reviews (3)

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Reviews
04/01/2021

    The IRAK1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    04/21/2020

      The IRAK1 protein's compatibility with various experimental techniques adds to its versatility.

      05/12/2017

        Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

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