Recombinant Human IRAK1 Protein, Myc/DDK-tagged

Cat.No. : IRAK1-1200H
Product Overview : Recombinant protein of human interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 3 with a C-Myc/DDK tag was expressed in HEK293T.
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Description : This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : HEK293T
Species : Human
Tag : Myc/DDK
Molecular Mass : 67.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
SDS-PAGE: Coomassie blue staining of purified IRAK1 protein. The protein was produced from HEK293T cells transfected with IRAK1 cDNA clone using MegaTran 2.0.
Gene Name : IRAK1 interleukin 1 receptor associated kinase 1 [ Homo sapiens (human) ]
Official Symbol : IRAK1
Synonyms : IRAK1; interleukin 1 receptor associated kinase 1; IRAK; pelle; interleukin-1 receptor-associated kinase 1; IRAK-1; Pelle homolog; EC 2.7.11.1
Gene ID : 3654
mRNA Refseq : NM_001025243
Protein Refseq : NP_001020414
MIM : 300283
UniProt ID : P51617

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting IRAK1 for cancer treatment? 03/16/2023

Yes, there are several clinical trials exploring the inhibition of IRAK1 as a therapeutic strategy for various types of cancer.

How is IRAK1 protein implicated in autoimmune diseases? 06/19/2020

IRAK1 is involved in the signaling pathways that can lead to the development of autoimmune diseases by regulating the immune system's response to self-antigens.

How does the expression of IRAK1 relate to inflammatory diseases? 01/08/2020

Elevated levels of IRAK1 expression have been observed in inflammatory diseases, suggesting its involvement in the dysregulation of inflammatory responses.

In what ways can IRAK1 be a target for drug development in inflammatory conditions? 08/23/2016

Inhibiting IRAK1 activity is being investigated as a potential therapeutic approach for managing inflammatory conditions, offering a target for drug development.

What clinical significance does IRAK1 hold in cancer research? 03/31/2016

IRAK1 has been identified as a potential target for cancer therapy, as it plays a role in promoting tumor growth and evasion of the immune system.

Customer Reviews (3)

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Reviews
04/01/2021

    The IRAK1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    04/21/2020

      The IRAK1 protein's compatibility with various experimental techniques adds to its versatility.

      05/12/2017

        Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

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