Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged

• Cat.No.: IRAK1-5436H
• Product Overview: Recombinant humanIRAK1 catalytic domain (amino acids 194-712), GST-tagged. No special measureswere taken to activate this kinase.

Specification

• Cat. No.: IRAK1-5436H
• Description: Nuclear factor kappa B (NF-κB)is a ubiquitous transcription factor and an essential mediator of geneexpression during activation of immune and inflammatory responses. NF-κBmediates the expression of a great variety of genes in response toextracellular stimuli including IL-1, TNFα and LPS. A serine/threonineprotein kinase associated with IL-1 receptor (IRAK) and its homologue mousepelle-like protein kinase (mPLK) were identified recently. IRAK is associatedwith the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding andserves as a signaling molecule to mediate IL-1 response.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Purity: ≥ 95% as determinedby SDS-PAGE analysis
• Molecular Weight: 83.4 kDa
• Biological Activity: 255 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 3.33μg/ml.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IRAK1

Gene Information

• Gene Name: IRAK1 interleukin-1receptor-associated kinase 1 [ Homo sapiens ]
• Synonyms: IRAK1; interleukin-1receptor-associated kinase 1; IRAK; pelle; EC 2.7.11.1; interleukin-1receptor-associated kinase 1; Pelle homolog
• Gene ID: 3654
• mRNA Refseq: NM_001025242
• Protein Refseq: NP_001020413
• MIM: 300283
• UniProt ID: P51617
• Chromosome Location: Xq28
• Pathway: Apoptosis; Neurotrophinsignaling pathway; Toll-like receptor signaling pathway; Signaling in Immunesystem; Signalling by NGF
• Function: ATP binding; NF-kappaB-inducingkinase activity; interleukin-1 receptor binding; nucleotide binding; proteinhomodimerization activity; protein serine/threonine kinase activity;transcription activator activity; transferase activity

Reviews

04/01/2021

The IRAK1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

04/21/2020

The IRAK1 protein's compatibility with various experimental techniques adds to its versatility.

05/12/2017

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

Q&As

Are there any ongoing clinical trials targeting IRAK1 for cancer treatment?

Yes, there are several clinical trials exploring the inhibition of IRAK1 as a therapeutic strategy for various types of cancer.

How is IRAK1 protein implicated in autoimmune diseases?

IRAK1 is involved in the signaling pathways that can lead to the development of autoimmune diseases by regulating the immune system's response to self-antigens.

How does the expression of IRAK1 relate to inflammatory diseases?

Elevated levels of IRAK1 expression have been observed in inflammatory diseases, suggesting its involvement in the dysregulation of inflammatory responses.

In what ways can IRAK1 be a target for drug development in inflammatory conditions?

Inhibiting IRAK1 activity is being investigated as a potential therapeutic approach for managing inflammatory conditions, offering a target for drug development.

What clinical significance does IRAK1 hold in cancer research?

IRAK1 has been identified as a potential target for cancer therapy, as it plays a role in promoting tumor growth and evasion of the immune system.