Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged IRAK1-5436H

Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged

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Cat.No. : IRAK1-5436H Optional Service: Optional requirements on this protein
Product Overview : Recombinant humanIRAK1 catalytic domain (amino acids 194-712), GST-tagged. No special measureswere taken to activate this kinase.
Description : Nuclear factor kappa B (NF-κB)is a ubiquitous transcription factor and an essential mediator of geneexpression during activation of immune and inflammatory responses. NF-κBmediates the expression of a great variety of genes in response toextracellular stimuli including IL-1, TNFα and LPS. A serine/threonineprotein kinase associated with IL-1 receptor (IRAK) and its homologue mousepelle-like protein kinase (mPLK) were identified recently. IRAK is associatedwith the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding andserves as a signaling molecule to mediate IL-1 response.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Purity : ≥ 95% as determinedby SDS-PAGE analysis
Molecular Weight : 83.4 kDa
Biological Activity : 255 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 3.33μg/ml.
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : IRAK1
Gene Name : IRAK1 interleukin-1receptor-associated kinase 1 [ Homo sapiens ]
Synonyms : IRAK1; interleukin-1receptor-associated kinase 1; IRAK; pelle; EC 2.7.11.1; interleukin-1receptor-associated kinase 1; Pelle homolog
Gene ID : 3654
mRNA Refseq : NM_001025242
Protein Refseq : NP_001020413
MIM : 300283
UniProt ID : P51617
Chromosome Location : Xq28
Pathway : Apoptosis; Neurotrophinsignaling pathway; Toll-like receptor signaling pathway; Signaling in Immunesystem; Signalling by NGF
Function : ATP binding; NF-kappaB-inducingkinase activity; interleukin-1 receptor binding; nucleotide binding; proteinhomodimerization activity; protein serine/threonine kinase activity;transcription activator activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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