Recombinant Human Interleukin-1 Receptor-Associated Kinase 1, GST-tagged
Cat.No. : | IRAK1-5436H |
Product Overview : | Recombinant humanIRAK1 catalytic domain (amino acids 194-712), GST-tagged. No special measureswere taken to activate this kinase. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IRAK1-5436H |
Description : | Nuclear factor kappa B (NF-κB)is a ubiquitous transcription factor and an essential mediator of geneexpression during activation of immune and inflammatory responses. NF-κBmediates the expression of a great variety of genes in response toextracellular stimuli including IL-1, TNFα and LPS. A serine/threonineprotein kinase associated with IL-1 receptor (IRAK) and its homologue mousepelle-like protein kinase (mPLK) were identified recently. IRAK is associatedwith the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding andserves as a signaling molecule to mediate IL-1 response. |
Source : | Insect cells |
Species : | Human |
Form : | Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol. |
Purity : | ≥ 95% as determinedby SDS-PAGE analysis |
Molecular Weight : | 83.4 kDa |
Biological Activity : | 255 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 3.33μg/ml. |
Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | IRAK1 |
Gene Name : | IRAK1 interleukin-1receptor-associated kinase 1 [ Homo sapiens ] |
Synonyms : | IRAK1; interleukin-1receptor-associated kinase 1; IRAK; pelle; EC 2.7.11.1; interleukin-1receptor-associated kinase 1; Pelle homolog |
Gene ID : | 3654 |
mRNA Refseq : | NM_001025242 |
Protein Refseq : | NP_001020413 |
MIM : | 300283 |
UniProt ID : | P51617 |
Chromosome Location : | Xq28 |
Pathway : | Apoptosis; Neurotrophinsignaling pathway; Toll-like receptor signaling pathway; Signaling in Immunesystem; Signalling by NGF |
Function : | ATP binding; NF-kappaB-inducingkinase activity; interleukin-1 receptor binding; nucleotide binding; proteinhomodimerization activity; protein serine/threonine kinase activity;transcription activator activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
IRAK1-1170H | Recombinant Human IRAK1 Protein (R194-S712), Tag Free | +Inquiry |
IRAK1-1171H | Recombinant Human IRAK1 Protein (R194-S712), GST tagged | +Inquiry |
IRAK1-869H | Recombinant Human IRAK1 protein, His-tagged | +Inquiry |
IRAK1-1542H | Recombinant Human IRAK1 Protein, His tagged | +Inquiry |
IRAK1-01H | Active Recombinant Human IRAK1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
IRAK1-5174HCL | Recombinant Human IRAK1 293 Cell Lysate | +Inquiry |
IRAK1-5173HCL | Recombinant Human IRAK1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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