Active Recombinant Human IRAK1 Protein, GST-tagged

• Cat.No.: IRAK1-01H
• Product Overview: Recombinant full-length human IRAK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cell
• Species: Human
• Tag: GST
• Bio-activity: The specific activity of IRAK1 was determined to be 31 nmol/min/mg
• Molecular Mass: 132 kDa
• Purity: > 90%
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: 20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, and 25% glycerol.
• Shipping: Dry ice.

Gene Information

• Gene Name: IRAK1 interleukin 1 receptor associated kinase 1 [ Homo sapiens (human) ]
• Official Symbol: IRAK1
• Synonyms: IRAK1; interleukin 1 receptor associated kinase 1; IRAK; pelle; interleukin-1 receptor-associated kinase 1; IRAK-1; Pelle homolog; EC 2.7.11.1
• Gene ID: 3654
• mRNA Refseq: NM_001569
• Protein Refseq: NP_001560
• MIM: 300283
• UniProt ID: P51617

Reviews

04/01/2021

The IRAK1 protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

04/21/2020

The IRAK1 protein's compatibility with various experimental techniques adds to its versatility.

05/12/2017

Its stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.

Q&As

Are there any ongoing clinical trials targeting IRAK1 for cancer treatment?

Yes, there are several clinical trials exploring the inhibition of IRAK1 as a therapeutic strategy for various types of cancer.

How is IRAK1 protein implicated in autoimmune diseases?

IRAK1 is involved in the signaling pathways that can lead to the development of autoimmune diseases by regulating the immune system's response to self-antigens.

How does the expression of IRAK1 relate to inflammatory diseases?

Elevated levels of IRAK1 expression have been observed in inflammatory diseases, suggesting its involvement in the dysregulation of inflammatory responses.

In what ways can IRAK1 be a target for drug development in inflammatory conditions?

Inhibiting IRAK1 activity is being investigated as a potential therapeutic approach for managing inflammatory conditions, offering a target for drug development.

What clinical significance does IRAK1 hold in cancer research?

IRAK1 has been identified as a potential target for cancer therapy, as it plays a role in promoting tumor growth and evasion of the immune system.