irf4

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irf4

Official Full Name interferon regulatory factor 4
Background The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
Synonyms IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF4-105H Recombinant Human IRF4 protein, T7/His-tagged E.coli T7/His
    Human IRF4-142H Recombinant Human Human Interferon Regulatory Factor 4 E.coli N/A
    Human IRF4-28543TH Recombinant Human IRF4 E.coli N/A
    Human IRF4-3565H Recombinant Human IRF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IRF4-5039H Recombinant Human IRF4 Protein, GST-tagged Wheat Germ GST
    Human IRF4-5165HCL Recombinant Human IRF4 293 Cell Lysate HEK293 N/A
    Human IRF4-726H Recombinant Human IRF4 Protein, GST-His-tagged E.coli GST/His
    Mouse Irf4-1749M Recombinant Mouse Irf4 protein, His & T7-tagged E.coli His/T7
    Mouse Irf4-3575M Recombinant Mouse Irf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque IRF4-2298R Recombinant Rhesus monkey IRF4 Protein, His-tagged Mammalian Cell His
    Chicken IRF4-5872C Recombinant Chicken IRF4 Mammalian Cell His

    irf4 involved in several pathways and played different roles in them. We selected most pathways irf4 participated on our site, such as Apoptosis, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with irf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis CYCSB; TNFSF10; HIST1H1E; TNF; AKT3A; PRKACAB; CASP12; BIRC5A; BMX; HIST1H1A
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes EGR3; EGR1; BATF3; EGR4; DGKA; CTLA4; CSF2; POU2F1; JUNB; IKZF1
    Cytokine Signaling in Immune system CSF2; TNIP2; FGF18B; IL1RN; CSF2RA; EIF4E3; IL17RD; DUSP5; IFIT3; SPRED1
    IL4-mediated signaling events TFF3; IRF4; EGR2; PARP14; IgG3; MYBL1; CCL26; NIPAL1; RETNLB; DOK2
    Immune System KIF20A; AP1S1; CTSLL; CTSK; ERAP2; SEC24A; CTSB; AMICA1; CR1; SIGLEC6
    Interferon Signaling HERC5; ISG20; TRIM8; IFI27; TRIM62; EIF4E3; TRIM3; IFI30; ADAR; TRIM6
    Interferon alpha/beta signaling IFI35; IFI6; XAF1; IFITM3; IFI27; IRF4; SAMHD1; GBP2; ISG20; BST2
    Interferon gamma signaling IRF4; TRIM29; TRIM48; GBP4; TRIM14; TRIM3; OASL; GBP6; TRIM62; TRIM6

    irf4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by irf4 itself. We selected most functions irf4 had, and list some proteins which have the same functions with irf4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NFATC2; SREBF2; TTC6; PAXBP1; RFX2; CTCFL; OTX2; ZNF543; SALL1; SPI1
    protein binding KCNJ5; LOX; LMNA; KCNJ15; ADRA2C; PPP6C; FHIT; SLC4A1A; RPAP3; CCDC53
    protein-lysine N-methyltransferase activity SETD4; METTL23; VCPKMT; PRDM12; SMYD2A; SMYD2B; PRMT8B; SETD7; RNMTL1A; EHMT1
    sequence-specific DNA binding SOX14; MEOX2B; DLX4B; DMBX1B; FOXN1; NKX6-1; RORCB; POU3F2A; PBX3B; DBX1B
    transcription factor activity, sequence-specific DNA binding TAL1; CSRNP2; ZNF573; PAX8; HOXA3A; IKZF3; ZFP35; KLF11; RXRA; ZNF286A
    transcription factor binding DACT2; NKX3; MYOCD; MAPK9; TLE1; CREBBP; TFDP1A; KEAP1; NAAA; FOXC1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MYOCD; NR4A1; RBPJ; HNRNPK; ONECUTL; GRHL1; NKX2; DDIT3; PAX8; KLF4

    irf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with irf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of irf4.

    IKBKAP; IRAK1; TLK2; YTHDC2; TRAF2; sSL2; caspa_human_gene; cflar_human_gene; PEG10; CARM1; VPS35; BAT2L

    Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
    White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

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