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IRF4

  • Official Full Name

    interferon regulatory factor 4

  • Overview

    The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the Ig heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenesis of B-cell lymphomas. It is an excellent marker for Reed-Sternberg cells of classic Hodgkin’s disease.
  • Synonyms

    IRF4; interferon regulatory factor 4; MUM1; LSIRF; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; NF-EM5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRF4-105H Recombinant Human IRF4 protein, T7/His-tagged E.coli T7/His
Human IRF4-726H Recombinant Human IRF4 Protein, GST-His-tagged E.coli GST/His
Human IRF4-142H Recombinant Human Human Interferon Regulatory Factor 4 E.coli N/A
Human IRF4-28543TH Recombinant Human IRF4 E.coli N/A
Human IRF4-5165HCL Recombinant Human IRF4 293 Cell Lysate HEK293 N/A
Human IRF4-1197H-B Recombinant Human IRF4 Protein Pre-coupled Magnetic Beads HEK293
Human IRF4-5039H Recombinant Human IRF4 Protein, GST-tagged Wheat Germ GST
Human IRF4-3565H Recombinant Human IRF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRF4-5739HF Recombinant Full Length Human IRF4 Protein, GST-tagged In Vitro Cell Free System GST 451 amino acids
Human IRF4-106H Recombinant Human IRF4 protein, His-tagged E.coli His 1-451 aa
Human IRF4-404HFL Recombinant Full Length Human IRF4 Protein, C-Flag-tagged Mammalian cells Flag
Human IRF4-1197H Recombinant Human IRF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRF4-2889H Recombinant Human IRF4 Protein (Glu130-Glu451), N-His tagged E.coli N-His Glu130-Glu451
Mouse Irf4-1749M Recombinant Mouse Irf4 protein, His & T7-tagged E.coli His/T7 Asp175~His433 (Accession # Q64287)
Mouse Irf4-3575M Recombinant Mouse Irf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque IRF4-2298R Recombinant Rhesus monkey IRF4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRF4-2119R Recombinant Rhesus Macaque IRF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IRF4-2119R-B Recombinant Rhesus Macaque IRF4 Protein Pre-coupled Magnetic Beads HEK293
Chicken IRF4-5872C Recombinant Chicken IRF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRF4 Related Articles

IRF4 involved in several pathways and played different roles in them. We selected most pathways IRF4 participated on our site, such as Apoptosis, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisTRADD;CASP9;TP53;DBNLA;DERL3;CASP10;IRF4;DSP;PPP3CCB
Calcineurin-regulated NFAT-dependent transcription in lymphocytesIRF4;DGKA;EGR4;POU2F1;CSF2;IKZF1;JUNB;BATF3;CDK4
Cytokine Signaling in Immune systemIFI35;ISG20;IRF2;FGF8B;IRF4;SPTBN2;DUSP1;PEA15A;MARK3
IL4-mediated signaling eventsPARP14;EGR2;MYBL1;DOK2;RETNLB;NIPAL1;IgG3;CCL26;IRF4
Immune SystemSOCS3A;KLRB1F;SUGT1;UBR1;DYNC1I2;FCN1;ASB14;GAN;RNF41
Interferon SignalingIFI6;TRIM62;IFI27;HLA-DQB2;TRIM26;ADAR;IRF4;TRIM68;GBP6
Interferon alpha/beta signalingXAF1;USP18;IRF9;IRF4;OASL;SAMHD1;GBP2;ISG20;MX2
Interferon gamma signalingTRIM17;TRIM38;TRIM3;TRIM68;TRIM29;TRIM31;TRIM45;OASL;IFI30

IRF4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF4 itself. We selected most functions IRF4 had, and list some proteins which have the same functions with IRF4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingHOXD13;EN1;ZSCAN21;ZFP746;NEUROD1;HNRNPK;ZNF92;RBPJB;TLX1
protein bindingDBC1;UBE2R2;AP4B1;NCOR2;OPA1;UBE3C;SLC9A7;FAM131B;C1orf105
protein-lysine N-methyltransferase activityAAAS;TRMT10B;EHMT1;EHMT2;METTL20;DIMT1;SMYD2;METTL23;PRDM12
sequence-specific DNA bindingHOXA3A;HOXD12;MAFGA;NR2F6A;ATF5;BCL6;HOXA13;BARHL1A;LMX1BA
transcription factor activity, sequence-specific DNA bindingZSCAN4D;MSRB2;GATAD2B;ZFP583;ALX3;E2F2;RARAA;ETS1;HNF1BA
transcription factor bindingTRIM11;IGHMBP2;MED12L;THRA;HES6;TRIM6;MYOD1;TBP;HDAC5
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingRAX;RBPJ;PPARA;POU3F2;NFIB;SIX4;SOX4;TLX1;TFE3B

IRF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF4.

IKBKAP; IRAK1; TLK2; YTHDC2; TRAF2; sSL2; caspa_human_gene; cflar_human_gene; PEG10; CARM1; VPS35; BAT2L

Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).
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