ISL1
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Official Full Name
ISL LIM homeobox 1
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Overview
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008] -
Synonyms
ISL1; ISL LIM homeobox 1; Isl-1; ISLET1; insulin gene enhancer protein ISL-1; islet-1; ISL1 transcription factor, LIM/homeodomain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- T7
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ISL1-28841TH | Recombinant Human ISL1 | E.coli | Non | 100 amino acids |
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| Human | ISL1-149H | Recombinant Human ISL1 Protein, T7/His/TEV-11R-tagged | E.coli | His&T7 |
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| Human | ISL1-129H | Recombinant Human ISL1 | E.coli | Non | 1-100 |
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| Human | ISL1-5149HCL | Recombinant Human ISL1 293 Cell Lysate | HEK293 | Non |
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| Human | ISL1-130H | Recombinant Human ISL1 protein, His-T7-tagged | E.coli | His&T7 | Met1~Gln191 |
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| Human | ISL1-5015H | Recombinant Human ISL1 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ISL1-3120H | Recombinant Human ISL1 Protein (Met1-Ala349), N-His tagged | E.coli | His | Met1-Ala349 |
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| Human | ISL1-5764HF | Recombinant Full Length Human ISL1 Protein, GST-tagged | In Vitro Cell Free System | GST | 346 amino acids |
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| Rat | ISL1-3102R | Recombinant Rat ISL1 Protein | Mammalian Cell | His |
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| Rat | ISL1-2758R | Recombinant Rat ISL1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | ISL1-2758R-B | Recombinant Rat ISL1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ISL1-8599Z | Recombinant Zebrafish ISL1 | Mammalian Cell | His |
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| Chicken | ISL1-6965C | Recombinant Chicken ISL1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ISL1 involved in several pathways and played different roles in them. We selected most pathways ISL1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | BMP4;RAF1;ID4;MAPK12;TCF3;SMARCAD1;FGFR4;SMAD5;ID1 |
ISL1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ISL1 itself. We selected most functions ISL1 had, and list some proteins which have the same functions with ISL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II activating transcription factor binding | T;MAD2L2;NHLH2;NFE2L2;EP300;EOMES;NEUROD1;LDB1;HIPK2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | TP73;PITX3;HOXA5;ALS2CR8;FOSL1;ZGPAT;JDP2;TCF4;NKX2-8 |
| RNA polymerase II transcription coactivator activity | ISL1;MED12L;POU1F1;MKL1B;PRRX1;SOX4;ANKRD1;SMARCA2;HYAL2 |
| bHLH transcription factor binding | ASCL1;BHLHE40;TWIST1;EP300;TCF3B;MAP3K10;LMO2;USF2;FOXH1 |
| chromatin binding | CBX1;GLI2;RCC1;FANCM;ARID3A;RNF20;DNMT3B;CITED1;RBPJ |
| enhancer sequence-specific DNA binding | FOXN4;KLF7B;LMO4;SOX11;TWIST1B;YY1;XBP1;MYT1;GATA2 |
| estrogen receptor binding | PRMT2;STRN;PPARGC1A;NKX3;PCNA;PPARG;TAF10;MED1;PPARGC1B |
| ligand-dependent nuclear receptor binding | SLC30A9;ISL1;JUND;NCOR2;PPARGC1A;TRIM24;MED1;ARID1A;SMARCE1 |
| protein binding | ZNF622;ZCCHC8;ADAMTSL5;C11orf54;DIAP1;CCNT1;MAGEA11;ZNF69;ELP3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NFAT5;MIXL1;POU4F3;MYB;FOXJ1;ATF2;HOXD13;PAX8;CARF |
| zinc ion binding | MEX3B;SF3A2;RNF182;TET1;UBR7;NR6A1B;TRIM60;SPG7;PXNA |
ISL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISL1.
ZNF511; CDK6; KDM1A; PLCG2; CDKN2B; CRK; SMAD3; RELA
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewIts stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the ISL1 protein.
It has consistently demonstrated outstanding results, consistently producing clear and sharp bands, allowing for accurate and reliable protein detection and quantification.
I highly recommend the ISL1 protein for its exceptional performance in Western blot analysis.
Q&As (5)
Ask a questionISL1 protein is utilized in clinical research to better understand its role in development and disease, and to develop potential therapeutic interventions.
Yes, ISL1 protein has been implicated in various heart diseases, including congenital heart defects and cardiac regeneration.
Some preclinical studies are exploring the potential of targeting ISL1 protein for cardiac regeneration and treatment of heart disease.
Mutations in the ISL1 gene have been associated with certain congenital heart defects and developmental disorders.
Some research suggests a potential link between ISL1 protein and neurodegenerative diseases, but further studies are needed to establish a definitive connection.
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