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JAG2

  • Official Full Name

    jagged 2

  • Overview

    The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    JAG2; jagged 2; protein jagged-2; HJ2; SER2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • His
  • Avi
  • GST
  • T7
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAG2-229H Active Recombinant Human JAG2, Fc Chimera CHO Fc
Human JAG2-29877TH Recombinant Human JAG2 Wheat Germ Non 90 amino acids
Human JAG2-382H Recombinant Human JAG2, Fc-tagged HEK293 Fc 1-1054
Human JAG2-601H Recombinant Human JAG2 Mammalian Cell His
Human JAG2-3182H Recombinant Human JAG2 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human JAG2-1869H Recombinant Human JAG2 protein, His-tagged E.coli His Phe714~His981
Human JAG2-3397H Recombinant Human JAG2 protein, His-GST-tagged E.coli His&GST Phe714~His981
Human JAG2-3182H-B Recombinant Human JAG2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Jag2-5666M Active Recombinant Mouse Jagged 2, Fc-tagged Mammalian cells Fc Met27-Lys1084
Mouse Jag2-383M Recombinant Mouse Jag2, Fc-tagged HEK293 Fc 24-1082
Mouse JAG2-8407M Recombinant Mouse JAG2 Protein Mammalian Cell His
Mouse Jag2-79M Recombinant Mouse Jag2 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse Jag2-79M-B Recombinant Mouse Jag2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Jag2-1870M Recombinant Mouse Jag2 protein, His & T7-tagged E.coli His&T7 Cys709~Pro941
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

JAG2 involved in several pathways and played different roles in them. We selected most pathways JAG2 participated on our site, such as Activated NOTCH1 Transmits Signal to the Nucleus, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated NOTCH1 Transmits Signal to the NucleusJAG1;DTX2;JAG2;DNER;DLK1;MIB1;CNTN1;ADAM10
Constitutive Signaling by NOTCH1 HD Domain MutantsMIB1;JAG1;JAG2;ADAM10
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsHDAC6;HEY2;MIB1;HEY1;JAG2;ADAM10;HEYL;HDAC5;CDK8
Constitutive Signaling by NOTCH1 PEST Domain MutantsHDAC6;JAG2;HEY1;ADAM10;HEY2;JAG1;CCNC;HDAC5;MIB1
Constitutive Signaling by NOTCH1 t(7JAG1;JAG2
9)(NOTCH1:M1580_K2555) Translocation MutantJAG1;JAG2
Delta-Notch Signaling PathwayHIVEP3;ASCL1;SMAD3B;ZFPM1;MAGEA1;CNTN1B;TLE1;ADAM10A;CNTN1
DiseaseEEF2;FKBP1A;PRELP;GPC5;OPN1MW;AP1G1;PACS1;STRA6;FMOD
Diseases of signal transductionKREMEN1;TRIM24;OPN1MW2;MIB1;HEYL;CUX1;CDK8;STRA6;FGFR1OP

JAG2 has several biochemical functions, for example, Notch binding, calcium ion binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAG2 itself. We selected most functions JAG2 had, and list some proteins which have the same functions with JAG2. You can find most of the proteins on our site.

Function Related Protein
Notch bindingEGFL7;JAG1A;JAG2B;DTX1;JAG1B;ADAM17;JAG2;DLL1;SNW1
calcium ion bindingS100A11;MAN1A;GUCA1D;ENPP1;PCDHB15;ANXA7;CPNE6;S100A8;ATP2A1
growth factor activityPDGFA;NRG3;CECR1;TGFA;PDGFAB;VEGFAB;NRTN;OSGIN1;CSF3
protein bindingARF4;GRIN2A;AOC3;ADAM22;CAPZA1;MTA2;NOLC1;CCNA1;IFIT2

JAG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAG2.

GFI1B; CACNA1A; ATXN7; ATN1; thrS2; q81wx2_bacan; q9wmx2-pro_0000037548

Research Area

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