JUND
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Official Full Name
jun D proto-oncogene -
Overview
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013] -
Synonyms
JUND;jun D proto-oncogene;AP-1;transcription factor jun-D;JunD-FL isoform;activator protein 1
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
JUND involved in several pathways and played different roles in them. We selected most pathways JUND participated on our site, such as ATF-2 transcription factor network,AhR pathway,Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUND were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | APPL2,TNK2,WNK1,RALBA,CEACAM1,KRT7,PITPNAA,GRB14,RALBB,DOK2 |
| Oncostatin M Signaling Pathway | CYR61 |
| MAPK signaling pathway | ARR3A,CACNG7A,FGFR3,RAC3,MOS,MEF2CB,CACNG6,MAPK8IP2,MAPT,PDGFRA |
| Corticotropin-releasing hormone | CYP11B1,CRHR1,KRT1,JUNB,KRT14,TBX19,CRHR2,CRH,PARP1,CYP11A1 |
| Integrated Pancreatic Cancer Pathway | CASP12,BRF1,CST3,NOXA1,MST1,FST,PPP1R13L,TOP2A,WRN,FKBP1B |
| AhR pathway | CYP1B1,JUN,NQO1,AIP,PTGES3,CYP1A1,CDKN1B,CYP1A2,EGFR,AHRR |
| ATF-2 transcription factor network | ATF2,CREB1,DUSP1,CBFB,RUVBL2,DUSP10,CSRP2,POU2F1,GADD45A,JUNB |
| Hypertrophy Model | MYOG,ADAM10A,MSTNB,MSTN,DUSP14,ANKRD1,ZEB1B,HBEGFB,IFRD1,CYR61 |
Protein Function
JUND has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUND itself. We selected most functions JUND had, and list some proteins which have the same functions with JUND. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | TP53,MTERFD1,KLF2A,CREB3L1,Arid4b,CREB3L2,IKZF2,NKX2,HOXA13,KLF4 |
| transcription coactivator activity | MED16,VGLL1,YAP1,MED17,USP16,TAF9,FHL5,RNF20,KDM5A,RNF14 |
| protein binding | BID,GPAA1,ZFPM2A,POLR3C,PTS,C3orf15,RRP8,UTP3,EPHA3,TRIM28 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MAFB,FOSB,RFX6,HELT,NKX2-5,FOXL2,MYBL2,FOSL1A,MAX,ZNF395 |
| ligand-dependent nuclear receptor binding | NCOR1,NCOA1,NCOA2,NCOR2,SLC30A9,BAZ2A,ARID1A,TRIP4,SMARCD3,TADA3 |
| enzyme binding | KDM4C,RCOR3,PTPN1,CDK19,AKT1,PHKG1,PDCD2,NOTCH3,NLRP1,DIS3L |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | PAX6,TFAP2E,ZSCAN1,ETV6,ZMYM5,ZNF488,FLI1A,PHB,FOXJ3,ZNF174 |
| transcription factor binding | DRG1,PAX2,SOX17,TRAPPC2,DNAJA3,IFI203,IRF4,ETS1,TAF7,HEY1 |
Interacting Protein
JUND has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUND here. Most of them are supplied by our site. Hope this information will be useful for your research of JUND.
FOS;q7lyy4_9dela;FOSL2;ACTR3;MDM2;AR
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References
- Matsumura, H; Ogata, Y; et al. Melatonin regulates human bone sialoprotein gene transcription. JOURNAL OF ORAL SCIENCE 56:67-76(2014).
- Zhou, LM; Matsumura, H; et al. Protamine stimulates bone sialoprotein gene expression. GENE 516:228-237(2013).
