KLF5

  • Official Full Name

    Kruppel-like factor 5 (intestinal)

  • Overview

    This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
  • Synonyms

    KLF5; Kruppel-like factor 5 (intestinal); CKLF; IKLF; BTEB2; Krueppel-like factor 5; BTE-binding protein 2; GC box binding protein 2; colon kruppel-like factor; colon krueppel-like factor; transcription factor BTEB2; intestinal-enriched kruppel-like factor; intestinal-enriched krueppel-like factor; basic transcription element binding protein 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N
  • T7|His
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLF5-133H Recombinant Human KLF5 protein, T7/His-tagged E.coli T7/His
Human KLF5-134H Recombinant Human KLF5 protein, His-tagged E.coli His Asp216~Asn457
Human KLF5-3003H Recombinant Human KLF5 Protein E.coli Tag Free
Human KLF5-3002H Recombinant Human KLF5 Protein (Leu85-Ala177), N-His tagged E.coli N-His Leu85-Ala177
Mouse KLF5-8685M Recombinant Mouse KLF5 Protein Mammalian Cell His
Mouse KLF5-4840M Recombinant Mouse KLF5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KLF5-4840M-B Recombinant Mouse KLF5 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KLF5 involved in several pathways and played different roles in them. We selected most pathways KLF5 participated on our site, such as Adipogenesis, Mus musculus biological processes, PluriNetWork, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisMEF2AA;GATA2A;HMGA1-RS1;BMP1;E2F4;KLF7A;CYP26A1;FOXC2;KLF6
Mus musculus biological processesSYNE2;SYCE2;SYCP1;MED11;POT1A;KLF5;SUN2
PluriNetWorkZFP143;ZMYM2;KLF5;SALL3;ZFP57;ZSCAN10;SMARCC1;IPO7;XPO4
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytesMED11;KLF5

KLF5 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF5 itself. We selected most functions KLF5 had, and list some proteins which have the same functions with KLF5. You can find most of the proteins on our site.

Function Related Protein
DNA bindingARID3B;THOC1;ORC1L;FOXN4;HLFB;FOXF1;HIST1H4H;CRY2;THAP3
RNA polymerase II core promoter proximal region sequence-specific DNA bindingCUX2;T;TFE3;PRDM5;ISL1;SMAD1;PRDM1;HOXA7;MYOD1
metal ion bindingCYP46A1.3;MEP1A.2;GM5077;ZBTB14;ZNF800B;PLAG1;ING5B;DMRTC2;ZNF559-ZNF177
nucleic acid bindingZNF831;ZXDB;BCL11AB;RNASE4;EGR2B;SALL3;ZFP579;ZFP553;RBPMS2
protein bindingACLY;SCRN2;Car8;HINFP;BMPR1B;RBM44;BTG3;SHMT2;RNF7
sequence-specific DNA bindingFOXL1;HOXA1;LEF1;GSX1;ZSCAN10;MAFK;POU2F2;PRRX1A;OTX1A
transcription factor activity, sequence-specific DNA bindingZNF37A;NCOR1;YEATS4;GABPA;RARGB;KAT7;FOXH1;RFX5;ATOH8
transcription factor bindingCEBPA;ATG7;VDRA;TAF7;TCF7L2;PIANP;MYOD1;TBP;PPARGC1A
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMYOCD;POU2F2;FUBP3;HOXD13;NR4A3;TLX1;OTX1;MITFA;HOXA5

KLF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF5.

Lyn; Pou5f1; Tfcp2l1; Nanog; Sall4

Research Area

Related articles

Gyorffy, B; Schafer, R; et al. Biomarkers Downstream of RAS: A Search for Robust Transcriptional Targets. CURRENT CANCER DRUG TARGETS 10:858-868(2010).
Rageul, J; Mottier, S; et al. KLF4-dependent, PPAR gamma-induced expression of GPA33 in colon cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 125:2802-2809(2009).
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