kmt2a
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Official Full Name
Recombinant Proteins
- Human
- Zebrafish
- Insect Cells
- E.coli
- Mammalian Cells
- GST
- His
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KMT2A-189H |
Active Recombinant Human KMT2A protein, GST-tagged
|
Insect Cells | Human | GST | 3738-end |
|
| KMT2A-127H | Recombinant Human KMT2A Protein, His-tagged | E.coli | Human | His | 1566-1784 |
|
| KMT2A-128H | Recombinant Human KMT2A Complex, His-tagged | E.coli | Human | His | 3745-3969;22-334;1-538;2-534;1-99 a.a. |
|
| KMT2A-54H | Recombinant Human KMT2A, GST-tagged | E.coli | Human | GST | 3735-3973 a.a. |
|
| KMT2A-6125Z | Recombinant Zebrafish KMT2A | Mammalian Cells | Zebrafish | His |
|
|
| KMT2A-001H | Recombinant Human KMT2A Protein | E.coli | Human |
|
||
| KMT2A-002H | Recombinant Human KMT2A Protein | E.coli | Human | 3762-3969 a.a. |
|
|
| KMT2A-006H | Recombinant Human MLL1/WAR Complex Protein, SUMOpro-tagged | E.coli | Human | SUMO |
|
|
| KMT2A-007H | Recombinant Human MLL1/WARD Complex Protein, SUMOpro-tagged | E.coli | Human | SUMO |
|
Involved Pathway
kmt2a involved in several pathways and played different roles in them. We selected most pathways kmt2a participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with kmt2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | SUV420H1,SETDB2,HADHAA,HADH,HADHAB,PLOD3,AGPHD1,SETMAR,ALDH7A1,WHSC1 |
Protein Function
kmt2a has several biochemical functions, for example, DNA binding,histone methyltransferase activity (H3-K4 specific),histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kmt2a itself. We selected most functions kmt2a had, and list some proteins which have the same functions with kmt2a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | IKZF1,RARAB,ZNF254,Trl,CEBPG,POLE4,ZNF383,FOXJ1B,PALB2,TIGD4 |
| zinc ion binding | XIAP,RNF213,SOLH,TNKS,APOBEC2A,POLE,APOBEC1,RNF24,ADAM32,Car4 |
| histone methyltransferase activity (H3-K4 specific) | WDR82,ASH1L,MLL1,WBP7,SMYD1B,KMT2E,MLL5,SETD3,WHSC1L1,SETMAR |
| metal ion binding | PMELA,TTC4,ERCC5,ZNF358,FGD4A,PPP4CA,PLCH2,COLEC12,ZIC2A,SMAD5 |
| transferase activity | UGT2B1,UGT1B4,GBGT1L1,PANK1A,FUT9D,EPHB4A,GGACT.2,AK5L,EPHB3A,PRKRIRA |
| histone-lysine N-methyltransferase activity | WBP7,SMYD2A,MLL5,SETD8B,AAAS,PRDM7,EZH1,SUV420H1,SUV39H1A,SMYD1 |
| methyltransferase activity | DNMT3,COMTA,METTL13,PRDM11,PRDM14,PRDM1,PRMT10,MLL5,PCMT,SMYD1B |
Interacting Protein
kmt2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kmt2a here. Most of them are supplied by our site. Hope this information will be useful for your research of kmt2a.
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References
- Sutton, R; Shaw, PJ; et al. Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY 168:395-404(2015).
- Kato, M; Hasegawa, D; et al. Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with KMT2A (MLL) rearrangements: a retrospective study from the paediatric acute lymphoblastic leukaemia working group of the Japan Society for Haematopoietic Cell Transplantation. BRITISH JOURNAL OF HAEMATOLOGY 168:564-570(2015).
