Recombinant Human KMT2A Protein


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Recombinant Human KMT2A Protein

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Cat.No. : KMT2A-002H
Product Overview : Recombinant C-terminal fragment of MLL1, residues 3762 - 3969, contains the SET1 domain for methyltransferase activity, and the WIN motif for binding the WAR complex without tag was expressed in E. coli. (An N-terminal hexahistidine tag and SUMOpro tag were removed by cleavage with SUMO protease 1)
Description : This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Molecular Mass : 24.1 kDa
Purity : ≥ 90% estimated by SDS-PAGE
Stability : ≥ 6 months
Storage : Store at -80 centigrade
Storage Buffer : 50 mM Tris, pH 8.0, with 400 nM sodium chloride, 10% glycerol, and 5 mM 2-mercaptoethanol
Shipping : Dry ice in continental US, may vary elsewhere.
Gene Name : KMT2A lysine methyltransferase 2A [ Homo sapiens (human) ]
Official Symbol : KMT2A
Synonyms : KMT2A; lysine methyltransferase 2A; HRX; MLL; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS; histone-lysine N-methyltransferase 2A; CXXC-type zinc finger protein 7; lysine (K)-specific methyltransferase 2A; lysine N-methyltransferase 2A; mixed lineage leukemia 1; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); trithorax-like protein; zinc finger protein HRX; EC
Gene ID : 4297
mRNA Refseq : NM_005933
Protein Refseq : NP_005924
MIM : 159555
UniProt ID : Q03164
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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