KPNA3

Official Full Name

karyopherin alpha 3 (importin alpha 4)
Overview

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.
Synonyms

KPNA3; karyopherin alpha 3 (importin alpha 4); importin subunit alpha-3; hSRP1; IPOA4; SRP1gamma; SRP4; SRP1 gamma; IMA3_HUMAN; Importin alpha 3; Importin alpha 3 subunit; Importin alpha 4; Importin alpha Q2; Karyopherin alpha 3; Karyopherin alpha 3 importin alpha 4; Karyopherin alpha 3 subunit; Karyopherin subunit alpha 3; Karyopherin subunit alpha-3; KPNA 3; Qip2; SRP1; SRP1-gamma; importin alpha-3; importin-alpha-Q2; OTTHUMP00000018426;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KPNA3-29810TH	Recombinant Human KPNA3	Wheat Germ	Non	100 amino acids	Inquiry
Human	KPNA3-7882H	Recombinant Human KPNA3 protein, His & T7-tagged	E.coli	His&T7	Glu3~Val220	Inquiry
Human	KPNA3-4890HCL	Recombinant Human KPNA3 293 Cell Lysate	HEK293	Non		Inquiry
Human	KPNA3-4895H	Recombinant Human KPNA3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	KPNA3-8799M	Recombinant Mouse KPNA3 Protein	Mammalian Cell	His		Inquiry
Mouse	Kpna3-1280M	Recombinant Mouse Kpna3 Protein, MYC/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	KPNA3-4897M	Recombinant Mouse KPNA3 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	KPNA3-4897M-B	Recombinant Mouse KPNA3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KPNA3-11467Z	Recombinant Zebrafish KPNA3	Mammalian Cell	His		Inquiry
Chicken	KPNA3-4115C	Recombinant Chicken KPNA3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

KPNA3 involved in several pathways and played different roles in them. We selected most pathways KPNA3 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes	IFIT8;KPNA5;EIF4G1;UBE2L6;NUP50;EIF4G2;EIF4A2;IFIT14;JAK1
Cytokine Signaling in Immune system	IFI6;JAK3;GBP4;SPTB;EDA;RASGRP1;FCGR1B;EDAR;TRIM48
Disease	NUP50;PRELP;HEY1;KPNA3;CCDC167;ANTXR1;JAG1;CPSF6;AP2M1
Host Interactions with Influenza Factors	KPNA5;KPNA3;CPSF4;KPNA4
ISG15 antiviral mechanism	EIF4E3;IFIT14;IFIT11;UBE2L6;MX2;ARIH1;USP18;IFIT12;IFIT8
Immune System	STIM1B;UBE2E3;DCTN3;POLR3H;PPAPDC1A;ASB4;NOD1;CLEC4A;BTLA
Infectious disease	EEF2;CHMP4C;CCDC167;KPNA5;SYT2;AP1S1;AP1M2;CHMP4B;CPSF4
Influenza Infection	IPO5;KPNA3;KPNA4;KPNA5;CPSF4

KPNA3 has several biochemical functions, for example, nuclear localization sequence binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA3 itself. We selected most functions KPNA3 had, and list some proteins which have the same functions with KPNA3. You can find most of the proteins on our site.

Function	Related Protein
nuclear localization sequence binding	NUP214;BRAP;TNPO1;KPNA6;KPNB3;TNPO2;KPNA7;TNPO3;KPNA1
protein C-terminus binding	CEP120;ATXN2;SAE1;ITPR1;MAP2K1;PFKM;GRIP1;CLIC6;COIL
protein binding	TRIM28;ITM2B;TARSL2;GCC1;METTL9;LTC4S;ANXA10;CD1d1;KRT7
protein transporter activity	XPO5;ITGB1BP1;ZFYVE16;KPNA5;SNUPN;RAMP2;AP1S3B;USO1;SEC62

KPNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA3.

CDKN1B; KPNB1; Ranbp2; Mkl1; CBX5

Research Area

Adaptor Proteins

Ben-Efraim, I; Frosst, PD; et al. Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr. BMC CELL BIOLOGY 10:-(2009).