kpna4 Protein, karyopherin alpha 4 (importin alpha 3)


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Official Full Name karyopherin alpha 4 (importin alpha 3)
Background The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
Synonyms KPNA4; karyopherin alpha 4 (importin alpha 3); importin subunit alpha-4; IPOA3; MGC12217; MGC26703; QIP1; SRP3; importin alpha Q1; karyopherin subunit alpha-4; FLJ31113
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KPNA4-29909TH Recombinant Human KPNA4 Protein, GST-tagged Wheat Germ GST
    Human KPNA4-4889HCL Recombinant Human KPNA4 293 Cell Lysate HEK293 N/A
    Mouse KPNA4-8800M Recombinant Mouse KPNA4 Protein Mammalian Cell His
    Chicken KPNA4-1811C Recombinant Chicken KPNA4 Mammalian Cell His
    Zebrafish KPNA4-11453Z Recombinant Zebrafish KPNA4 Mammalian Cell His

    kpna4 involved in several pathways and played different roles in them. We selected most pathways kpna4 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with kpna4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antiviral mechanism by IFN-stimulated genes IFIT12; DPF1; KPNA5; EIF4EB; MX2; EIF4G1; HERC5; IFIT14; UBE2L6; IFIT11
    Cytokine Signaling in Immune system ARIH1; HBEGF; SPRED2; UBE2L6; NRG2A; JAK3; HAVCR2; PAQR3A; TNFSF13B; TNIP2
    Disease PSTPIP2; VPS37A; AP2M1; NA; TH1L; CHMP4C; TIRAP; SYT2; RCC1; CTBP1
    Host Interactions with Influenza Factors KPNA5; CPSF4; KPNA4; KPNA3
    ISG15 antiviral mechanism USP18; EIF4G2A; IFIT12; HERC5; IFIT8; IFIT14; IFIT10; EIF4G2; KPNA3; ARIH1L
    Immune System TIRAP; WASF2; DEFA3; IgG3; LY86; CTSK; TRIM22; TRIM62; CD200R3; ASB7
    Infectious disease CHMP4C; LTF; KPNA3; STX1B; KPNA5; NMT2; DOCK2; APOBEC3G; AP1G1; CHMP4B
    Influenza Infection IPO5; KPNA3; CPSF4; KPNA4; KPNA5

    kpna4 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kpna4 itself. We selected most functions kpna4 had, and list some proteins which have the same functions with kpna4. You can find most of the proteins on our site.

    Function Related Protein
    nuclear localization sequence binding IPO4; KPNA7; KPNA5; IPO13; KPNA6; KPNA2; TNPO3; BRAP; KPNA4; KPNB3
    protein binding MIEN1; ANLN; PAK1; C1orf51; PIP5K1B; MEOX2; PAFAH1B1; YY1A; RHOH; TPX2
    protein transporter activity USO1; IPO11; AP2S1; AP1S1; TNPO3; KPNB3; AP1G2; IPO4; AP3S1; AP1S3B

    kpna4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kpna4 here. Most of them are supplied by our site. Hope this information will be useful for your research of kpna4.

    gag-pol; HNRNPC; CYHR1; Ranbp2; MAT2B; NUP50; PLAA

    Arjomand, A; Baker, MA; et al. The alpha-importome of mammalian germ cell maturation provides novel insights for importin biology. FASEB JOURNAL 28:3480-3493(2014).
    Whiley, PAF; Miyamoto, Y; et al. Changing subcellular localization of nuclear transport factors during human spermatogenesis. INTERNATIONAL JOURNAL OF ANDROLOGY 35:158-169(2012).

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