KRT2

Official Full Name

Keratin 2
Background

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Synonyms

K2e; KRTE; CK-2e; KRT2A; KRT2E; MGC116967; MGC116968; KRT2; keratin, type II cytoskeletal 2 epidermal; keratin-2e; keratin-2 epidermis; cytokeratin-2e; type-II keratin Kb2; epithelial keratin-2e; epidermal ichthyosis bullosa of Siemens;

Type:
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse
Rat

Source :
E.coli
HEK293
Mammalian Cell

Tag :
His
His (Fc)
Avi
His|S
His|T7

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	KRT2-457H	Recombinant Human KRT2, His-tagged	E.coli	His	$319.00 / 25ug
Human	KRT2-2697H	Recombinant Human KRT2 protein, His-tagged	E.coli	His	Inquiry
Human	KRT2-2413H	Recombinant Human KRT2 Protein (Cys7-Leu160), His tagged	E.coli	His	Inquiry
Mouse	Krt2-2698M	Recombinant Mouse Krt2 protein, His & T7-tagged	E.coli	His/T7	Inquiry
Mouse	KRT2-8823M	Recombinant Mouse KRT2 Protein	Mammalian Cell	His	Inquiry
Mouse	KRT2-4915M-B	Recombinant Mouse KRT2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	KRT2-4915M	Recombinant Mouse KRT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	KRT2-3317R	Recombinant Rat KRT2 Protein	Mammalian Cell	His	Inquiry
Rat	Krt2-2699R	Recombinant Rat Krt2 protein, His & S-tagged	E.coli	His/S	Inquiry
Rat	Krt2-2700R	Recombinant Rat Krt2 protein, His-tagged	E.coli	His	Inquiry
Rat	KRT2-2973R	Recombinant Rat KRT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	KRT2-2973R-B	Recombinant Rat KRT2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KRT2 Related Articles

KRT2 involved in several pathways and played different roles in them. We selected most pathways KRT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

KRT2 has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT2 itself. We selected most functions KRT2 had, and list some proteins which have the same functions with KRT2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	TCEB2;HFE2;TFAP4;PPP2R1B;PRLR;KIAA1737;COPS7A;TARSL2;DYRK1A
structural constituent of cytoskeleton	TUBG1;ACTA1;TUBB4B;COX4I2;SPTBN1;KRT2;ATXN1;KRT6B;INA

KRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT2.

KRT13; KRT38; KRT19; KRT31; KRT40; PPP2R2B; midostaurin

Mckenzie, GW; Arora, R; et al. Genetic variation in the 5'UTR of the KRT2.13 gene of sheep. ANIMAL SCIENCE JOURNAL 83:194-198(2012).

Wang, WH; Song, SJ; et al. Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type. EUROPEAN JOURNAL OF DERMATOLOGY 20:567-572(2010).