KRT2
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Official Full Name
Keratin 2 -
Overview
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. -
Synonyms
K2e;KRTE;CK-2e;KRT2A;KRT2E;MGC116967;MGC116968;KRT2;keratin, type II cytoskeletal 2 epidermal;keratin-2e;keratin-2 epidermis;cytokeratin-2e;type-II keratin Kb2;epithelial keratin-2e;epidermal ichthyosis bullosa of Siemens
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- T7
- S
- Avi
- Fc
- Myc
Involved Pathway
KRT2 involved in several pathways and played different roles in them. We selected most pathways KRT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KRT2 has several biochemical functions, for example, protein binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT2 itself. We selected most functions KRT2 had, and list some proteins which have the same functions with KRT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | GFAP,TUBB6,TUBGCP3,NEFM,SYNM,TUBGCP2,KRT17,KRT20,TUBA4A,ACTR2 |
| protein binding | EHD1,RLTPR,KIF2C,PLXND1,FAM156A,BAIAP2,FST,MYRIP,OAZ1,SGPL1 |
Interacting Protein
KRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT2.
KRT13;KRT38;KRT19;KRT31;KRT40;PPP2R2B;midostaurin
Resources
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References
- Mckenzie, GW; Arora, R; et al. Genetic variation in the 5'UTR of the KRT2.13 gene of sheep. ANIMAL SCIENCE JOURNAL 83:194-198(2012).
- Wang, WH; Song, SJ; et al. Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type. EUROPEAN JOURNAL OF DERMATOLOGY 20:567-572(2010).
