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KRT2

  • Official Full Name

    Keratin 2

  • Overview

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
  • Synonyms

    K2e; KRTE; CK-2e; KRT2A; KRT2E; MGC116967; MGC116968; KRT2; keratin, type II cytoskeletal 2 epidermal; keratin-2e; keratin-2 epidermis; cytokeratin-2e; type-II keratin Kb2; epithelial keratin-2e; epidermal ichthyosis bullosa of Siemens;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|S
  • His|T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KRT2-457H Recombinant Human KRT2, His-tagged E.coli His 210-331aa
Human KRT2-2697H Recombinant Human KRT2 protein, His-tagged E.coli His Cys7~Leu160 (Accession # P35908)
Human KRT2-2413H Recombinant Human KRT2 Protein (Cys7-Leu160), His tagged E.coli His Cys7-Leu160
Mouse Krt2-2698M Recombinant Mouse Krt2 protein, His & T7-tagged E.coli His/T7 Arg200~Glu508 (Accession # Q3TTY5)
Mouse KRT2-8823M Recombinant Mouse KRT2 Protein Mammalian Cell His
Mouse KRT2-4915M-B Recombinant Mouse KRT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse KRT2-4915M Recombinant Mouse KRT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KRT2-3317R Recombinant Rat KRT2 Protein Mammalian Cell His
Rat Krt2-2699R Recombinant Rat Krt2 protein, His & S-tagged E.coli His/S Glu508~Arg685 (Accession # Q6IG02)
Rat Krt2-2700R Recombinant Rat Krt2 protein, His-tagged E.coli His Ile368~Glu507 (Accession # Q6IG02)
Rat KRT2-2973R Recombinant Rat KRT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KRT2-2973R-B Recombinant Rat KRT2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KRT2 involved in several pathways and played different roles in them. We selected most pathways KRT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

KRT2 has several biochemical functions, for example, protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT2 itself. We selected most functions KRT2 had, and list some proteins which have the same functions with KRT2. You can find most of the proteins on our site.

Function Related Protein
protein bindingPRLHR;PRELID1;XRCC1;MNAT1;NAT2;PLK1S1;EHMT1;IL13RA1;ATG14
structural constituent of cytoskeletonTUBB2B;TUBA8L;TNNT2A;ACTL7A;BFSP1;CCDC6;TUBA3E;F-KER;TUBA1B

KRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT2.

KRT13; KRT38; KRT19; KRT31; KRT40; PPP2R2B; midostaurin

Research Area

Related articles

Mckenzie, GW; Arora, R; et al. Genetic variation in the 5'UTR of the KRT2.13 gene of sheep. ANIMAL SCIENCE JOURNAL 83:194-198(2012).
Wang, WH; Song, SJ; et al. Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type. EUROPEAN JOURNAL OF DERMATOLOGY 20:567-572(2010).
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