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KRT5

Official Full Name

keratin 5
Overview

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Synonyms

KRT5; keratin 5; K5; CK5; DDD; DDD1; EBS2; KRT5A; keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KRT5-05H	Recombinant Human KRT5 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	KRT5-147H	Recombinant Human KRT5, His-tagged	E.coli	His	1-590aa	Inquiry
Human	KRT5-468H	Recombinant Human KRT5, GST-tagged	E.coli	GST	67-130aa	$319 / 25μg
Human	KRT5-2691H	Recombinant Human KRT5 protein, His & S-tagged	E.coli	His&S	Thr166~Leu474	Inquiry
Human	KRT5-4868HCL	Recombinant Human KRT5 293 Cell Lysate	HEK293	Non		Inquiry
Human	KRT5-2708H	Recombinant Human KRT5 protein, His-tagged	E.coli	His	316-491 aa	$319 / 25μg
Human	KRT5-1078H	Recombinant Human KRT5 Protein, His-tagged	E.coli	His	Ile335-Glu473	Inquiry
Human	KRT5-737HF	Recombinant Full Length Human KRT5 Protein, GST-tagged	In Vitro Cell Free System	GST	590 amino acids	Inquiry
Human	KRT5-4383H	Recombinant Human KRT5 Protein (Thr166-Leu474), N-His tagged	E.coli	His	Thr166-Leu474	Inquiry
Mouse	Krt5-2692M	Recombinant Mouse Krt5 protein, His-tagged	E.coli	His	Arg163~Glu471	Inquiry
Rat	KRT5-3326R	Recombinant Rat KRT5 Protein	Mammalian Cell	His		Inquiry
Rat	Krt5-2693R	Recombinant Rat Krt5 protein, His & S-tagged	E.coli	His&S	Ile335~Glu473	Inquiry
Rat	KRT5-2982R	Recombinant Rat KRT5 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	KRT5-2982R-B	Recombinant Rat KRT5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KRT5-8770Z	Recombinant Zebrafish KRT5	Mammalian Cell	His		Inquiry
Chicken	KRT5-1075C	Recombinant Chicken KRT5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

KRT5 involved in several pathways and played different roles in them. We selected most pathways KRT5 participated on our site, such as Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glucocorticoid receptor regulatory network	SMARCA4;SMARCC2;POU2F1;BGLAP;KRT14;CSN2;KRT17;SMARCD1;EGR1

KRT5 has several biochemical functions, for example, protein binding, scaffold protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT5 itself. We selected most functions KRT5 had, and list some proteins which have the same functions with KRT5. You can find most of the proteins on our site.

Function	Related Protein
protein binding	LDLRAD1;GPI1;ZBTB5;KHDRBS1;PRDM4;RFX5;TLX3;FBXL12;CCND3
scaffold protein binding	GRIN2A;VIM;SHANK3;CIT;NLGN1;CASP8;CRIPT;KCNQ1;MAPK3
structural constituent of cytoskeleton	TUBA2;KRT6B;KRT5;TUBA3E;SPTBN1;BKJ;VIM;TPM1;TNNT2A

KRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT5.

KRT38; KRT15; KRT31; KRT40; KIFC3; ALOX12

Research Area

Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).

Shum, WW; Smith, TB; et al. Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 90:-(2014).