KRT5

  • Official Full Name

    keratin 5

  • Overview

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
  • Synonyms

    KRT5; keratin 5; K5; CK5; DDD; DDD1; EBS2; KRT5A; keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KRT5-05H Recombinant Human KRT5 protein, GST-tagged Wheat Germ GST
Human KRT5-147H Recombinant Human KRT5, His-tagged E.coli His
Human KRT5-468H Recombinant Human KRT5, GST-tagged E.coli GST
Human KRT5-2691H Recombinant Human KRT5 protein, His & S-tagged E.coli His/S
Human KRT5-4868HCL Recombinant Human KRT5 293 Cell Lysate HEK293 N/A
Human KRT5-2708H Recombinant Human KRT5 protein, His-tagged E.coli His
Human KRT5-1078H Recombinant Human KRT5 Protein, His-tagged E.coli N-His
Human KRT5-737HF Recombinant Full Length Human KRT5 Protein, GST-tagged In Vitro Cell Free System GST
Human KRT5-4383H Recombinant Human KRT5 Protein (Thr166-Leu474), N-His tagged E.coli N-His
Mouse Krt5-2692M Recombinant Mouse Krt5 protein, His-tagged E.coli His
Rat KRT5-3326R Recombinant Rat KRT5 Protein Mammalian Cell His
Rat Krt5-2693R Recombinant Rat Krt5 protein, His & S-tagged E.coli His/S
Rat KRT5-2982R Recombinant Rat KRT5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KRT5-2982R-B Recombinant Rat KRT5 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KRT5-8770Z Recombinant Zebrafish KRT5 Mammalian Cell His
Chicken KRT5-1075C Recombinant Chicken KRT5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KRT5 Related Articles

KRT5 involved in several pathways and played different roles in them. We selected most pathways KRT5 participated on our site, such as Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glucocorticoid receptor regulatory networkCSN2;KRT17;NR1I3;SMARCD1;BGLAP;KRT14;SMARCA4;EGR1;POU2F1

KRT5 has several biochemical functions, for example, protein binding, scaffold protein binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT5 itself. We selected most functions KRT5 had, and list some proteins which have the same functions with KRT5. You can find most of the proteins on our site.

Function Related Protein
protein bindingNUAK2;ZCCHC12;FAM64A;CD47;ECM1;MRPS9;F3;SCMH1;SRMS
scaffold protein bindingMAP2K2;DSP;PARK7;CAV2;NCK2;HOMER1;CACNA1H;TREM2;SHANK3
structural constituent of cytoskeletonTUBA1L;SPRR2A1;YEATS4;EPB41L3;NEFL;ACTL7A;DES;NEFH;SORBS3

KRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT5.

KRT38; KRT15; KRT31; KRT40; KIFC3; ALOX12

Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).
Shum, WW; Smith, TB; et al. Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 90:-(2014).
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