KRT5
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Official Full Name
keratin 5 -
Overview
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] -
Synonyms
KRT5;keratin 5;K5;CK5;DDD;DDD1;EBS2;KRT5A;keratin, type II cytoskeletal 5;CK-5;cytokeratin-5;58 kda cytokeratin;type-II keratin Kb5;epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types;keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- S
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KRT5-468H | Recombinant Human KRT5, GST-tagged | E.coli | Human | GST | 67-130aa | |
| KRT5-2708H | Recombinant Human KRT5 protein, His-tagged | E.coli | Human | His | 316-491 aa | |
| KRT5-05H | Recombinant Human KRT5 protein, GST-tagged | Wheat Germ | Human | GST |
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| KRT5-1075C | Recombinant Chicken KRT5 | Mammalian Cells | Chicken | His |
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| KRT5-147H | Recombinant Human KRT5, His-tagged | E.coli | Human | His | 1-590aa |
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| KRT5-2691H | Recombinant Human KRT5 protein, His & S-tagged | E.coli | Human | His&S | Thr166~Leu474 |
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| Krt5-2692M | Recombinant Mouse Krt5 protein, His-tagged | E.coli | Mouse | His | Arg163~Glu471 |
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| Krt5-2693R | Recombinant Rat Krt5 protein, His & S-tagged | E.coli | Rat | His&S | Ile335~Glu473 |
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| KRT5-3326R | Recombinant Rat KRT5 Protein | Mammalian Cells | Rat | His |
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| KRT5-8770Z | Recombinant Zebrafish KRT5 | Mammalian Cells | Zebrafish | His |
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| KRT5-4868HCL | Recombinant Human KRT5 293 Cell Lysate | HEK293 | Human | Non |
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| KRT5-1078H | Recombinant Human KRT5 Protein, His-tagged | E.coli | Human | His | Ile335-Glu473 |
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| KRT5-2982R | Recombinant Rat KRT5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KRT5-2982R-B | Recombinant Rat KRT5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KRT5-4383H | Recombinant Human KRT5 Protein (Thr166-Leu474), N-His tagged | E.coli | Human | His | Thr166-Leu474 |
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| KRT5-737HF | Recombinant Full Length Human KRT5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 590 amino acids |
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Involved Pathway
KRT5 involved in several pathways and played different roles in them. We selected most pathways KRT5 participated on our site, such as Glucocorticoid receptor regulatory network, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glucocorticoid receptor regulatory network | BGLAP,NR1I3,SMARCC2,CSN2,EGR1,KRT14,SMARCD1,POU2F1,SMARCA4,KRT17 |
Protein Function
KRT5 has several biochemical functions, for example, protein binding,scaffold protein binding,structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT5 itself. We selected most functions KRT5 had, and list some proteins which have the same functions with KRT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| scaffold protein binding | HOMER1,SHANK1,CHUK,TREM1,KRT8,GRID2,GRIN2A,DLG4,MAPK3,DSP |
| structural constituent of cytoskeleton | TUBA4A,KRT71,SPTAN1,YEATS4,ARPC4,BICD1,TUBA1A,CYLC2,NEFH,TNNT2A |
| protein binding | ADAP1,CDK5RAP3,SEC22B,CSF3R,MALSU1,SEC61B,TLN1,CAV3,SGK1,CCNF |
Interacting Protein
KRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT5.
KRT38;KRT15;KRT31;KRT40;KIFC3;ALOX12
Resources
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References
- Shum, WW; Smith, TB; et al. Epithelial Basal Cells Are Distinct from Dendritic Cells and Macrophages in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 90:-(2014).
- Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).
