L3MBTL1

Official Full Name

l(3)mbt-like 1 (Drosophila)
Overview

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

L3MBTL1; l(3)mbt-like 1 (Drosophila); l(3)mbt (Drosophila) like , l(3)mbt like (Drosophila) , L3MBTL; lethal(3)malignant brain tumor-like protein 1; dJ138B7.3; DKFZp586P1522; KIAA0681; lethal (3) malignant brain tumor l(3); RGD1307316; H-L(3)MBT; H-l(3)mbt protein; L(3)mbt protein homolog; L(3)mbt-like; L3MBT; LMBL1_HUMAN; L3MBTL;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	L3MBTL1-124H	Recombinant Human L3MBTL1 Protein, GST-tagged	E.coli	GST	200-522	Inquiry
Human	L3MBTL1-254H	Recombinant Human L3MBTL1 protein, GST-tagged	E.coli	GST	190-530	Inquiry
Human	L3MBTL1-125H	Recombinant Human L3MBTL1 Protein, His-tagged	E.coli	His	199-522	Inquiry
Human	L3MBTL1-255H	Recombinant Human CBX1 protein, GST-tagged	E.coli	GST	1-185	Inquiry
Human	L3MBTL1-964HCL	Recombinant Human L3MBTL1 cell lysate		Non		Inquiry
Human	L3MBTL1-5601H	Recombinant Human L3MBTL1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Mouse	L3MBTL1-8916M	Recombinant Mouse L3MBTL1 Protein	Mammalian Cell	His		Inquiry
Mouse	L3MBTL1-4970M-B	Recombinant Mouse L3MBTL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	L3MBTL1-4970M	Recombinant Mouse L3MBTL1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	L3mbtl1-3743M	Recombinant Mouse L3mbtl1 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
	Kit-1779	L3MBTL1 Inhibitor Screening Assay Kit		Non		Inquiry
	Kit-1780	L3MBTL1 TR-FRET Assay Kit		Non		Inquiry
	Kit-1966	L3MBTL1 MBT Domains TR-FRET Assay Kit		Non		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

L3MBTL1 involved in several pathways and played different roles in them. We selected most pathways L3MBTL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with L3MBTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

L3MBTL1 has several biochemical functions, for example, SAM domain binding, chromatin binding, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by L3MBTL1 itself. We selected most functions L3MBTL1 had, and list some proteins which have the same functions with L3MBTL1. You can find most of the proteins on our site.

Function	Related Protein
SAM domain binding
chromatin binding	SSRP1;HMGB3A;MEF2C;ZKSCAN3;FOXO1;MB21D2;PRDM11;TLE4;OST4
histone binding	SET;NCAPD2;BAZ2A;ANP32E;HIST1H3E;H3F3B;ATAD2;HIST1H4J;NCAPD3
identical protein binding	RIPK1;BNIP3L;ATG16L1;C;PLDN;SERPINA1;APLP2;PARK2;TNPO3
methylated histone binding	CHD8;CDYL2;SUZ12;MSL3;MPHOSPH8;CBX5;ING3;PHF1;L3MBTL1
nucleosomal histone binding	VRK1;L3MBTL1;UHRF1
nucleosome binding	SMARCA5;NOC2L;L3MBTL1;DNTTIP1;RNF4;MUM1;ARID1A;RNF169;HP1BP3
protein binding	C16orf45;NR1D2;NPHP3;UQCRH;APOBEC1;ADAMTSL5;OSBPL7;TEAD2;TECPR2
transcription factor activity, sequence-specific DNA binding	KDM5A;NFKB1;ZSCAN4F;RFXANK;FOXC1B;MAFG;NR4A2A;HOXB6;FOXD1
zinc ion binding	ACE;S100A12;BMP1B;CA15C;RNF121;CNOT4;QPCT;TRIM54;MMP1

L3MBTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L3MBTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of L3MBTL1.

HIST2H4B; HIST1H1E; HIST1H3D; RB1; CBX3

Research Area

Carlson, SM; Moore, KE; et al. Proteome-wide enrichment of proteins modified by lysine methylation. NATURE PROTOCOLS 9:37-50(2014).

Edwards, CR; Dang, WW; et al. Histone H4 Lysine 20 of Saccharomyces cerevisiae Is Monomethylated and Functions in Subtelomeric Silencing. BIOCHEMISTRY 50:10473-10483(2011).