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LAMA2

  • Official Full Name

    laminin, alpha 2

  • Overview

    Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix compo
  • Synonyms

    LAMA2; laminin, alpha 2; LAMM; laminin subunit alpha-2; congenital muscular dystrophy; merosin; laminin M chain; merosin heavy chain; laminin-2 subunit alpha; laminin-4 subunit alpha; laminin-12 subunit alpha;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LAMA2-27944TH Recombinant Human LAMA2 protein, GST-tagged Wheat Germ GST
Human LAMA2-0367H Active Recombinant Human LAMA2 protein, Fc-tagged HEK293 Fc Leu1900-Ala2722(Lamininalpha2E8)&Leu1573-Gln1798(Lamininbeta2E8)&Asn1364-Pro1609(Laminingamma1E8)
Mouse Lama2-210M Recombinant Mouse Lama2 Protein, His-tagged E.coli His Ser2901~Asn3106
Zebrafish LAMA2-8310Z Recombinant Zebrafish LAMA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LAMA2 Related Articles

LAMA2 involved in several pathways and played different roles in them. We selected most pathways LAMA2 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayITGA1;GYS1;GNGT2;Il6ra;PPP2CA;RPTOR;HSP90AB1;IFNA4;CD19
Focal adhesionKDR;PIK3R3B;ARHGAP35;TNR;PDPK1;TNXB;HRASB;CCND2A;ROCK2B
ECM-receptor interactionGP6;COL3A1;LAMC1;LAMC3;COL1A1A;ITGA6;TNC;VTNB;ITGA7
ToxoplasmosisLAMB2;MAP3K7;ITGA6;PIK3CD;PIK3CA;IKBKG;LAMA3;MAP2K3;BCL2
AmoebiasisPLCB2;LAMB3;SERPINB10;TNF;CD1d1;TLR2;COL4A3;Casp3;SERPINB3
Pathways in cancerPRKACG;HSP90B1;PIK3R3;STK36;PTGER1;APPL1;RELA;FGF1;TCF7L2
Small cell lung cancerLAMB1;BCL2;SKP2;RB1;COL4A1;NFKB1;LAMB2;LAMB3;LAMA5
Hypertrophic cardiomyopathy (HCM)DMD;RYR2;ITGA6;CACNA2D2;MYL2;ITGA7;TPM1;CACNA2D4;IL6
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CACNA2D2;Itga10&Itgb1;SGCA;CACNG7;DSP;ITGB8;CTNNA1;ITGB4;CACNB1
Dilated cardiomyopathyACTB;TPM1;ITGA4;ITGA2;ITGA6;TNNC1;ITGA5;ITGB1;SLC8A1
Viral myocarditisSGCB;HLA-DRA;FYN;CCND1;HLA-B;CD86;ICAM1;HLA-C;HLA-F

LAMA2 has several biochemical functions, for example, receptor binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA2 itself. We selected most functions LAMA2 had, and list some proteins which have the same functions with LAMA2. You can find most of the proteins on our site.

Function Related Protein
receptor bindingICOSLG;WNT5B;WIPI1;WNT2BB;KNG1;H2-Q10;HACL1;CADM1;ABCA1
structural molecule activityLAMA3;COPG;CLTA;EIF3A;PGM5;SNTG2;PRPH;KRT73;KRT39

LAMA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA2.

DAG1; GAMMAHV.ORF33; SNAPIN; TRIM63; ENTHD2; SMC6; Naa10

Niibori-Nambu, A; Midorikawa, U; et al. Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin alpha V. PLOS ONE 8:-(2013).
Mendell, JR; Boue, DR; et al. The congenital muscular dystrophies: Recent advances and molecular insights. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY 9:427-443(2006).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How do I measure the expression level of LAMA2 protein? 07/28/2023

The expression level of LAMA2 protein can be detected by a variety of methods, such as western blotting, immunofluorescence staining, PCR, etc. These methods can help us understand the expression of LAMA2 protein in different tissues and cells, as well as how it changes under different physiological or pathological conditions.

What is the expression pattern of LAMA2 protein? 04/23/2023

The expression pattern of LAMA2 protein may be tissue-specific, and expression levels may vary in different tissues. Its expression pattern may be affected by a variety of factors, including gene regulation, transcription factors, etc.

What diseases are associated with the abnormal expression of LAMA2 protein?The abnormal expression of LAMA2 01/29/2022

Protein may be related to a variety of diseases, such as hereditary muscular dystrophy, cardiomyopathy, etc. The occurrence of these diseases may be related to mutations or abnormal expression of the LAMA2 gene, resulting in abnormal extracellular matrix and destruction of tissue structure.

What are the effects of mutations or modifications in the LAMA2 protein on organisms? 08/29/2021

Mutations or modifications of the LAMA2 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification, which may lead to abnormalities in the tissue structure and the occurrence of disease.

What is the function of the LAMA2 protein? 08/26/2021

The main function of the LAMA2 protein may be that it is a component of the extracellular matrix and is involved in maintaining tissue structure and stability. It may exert these functions through interactions with cell surface receptors or other matrix components.

How does LAMA2 protein interact with other proteins? 09/12/2020

The LAMA2 protein may interact with other proteins to fulfill its function. These interactions may involve multiple types of protein-protein interactions, such as the binding of integrin receptors to LAMA2. Understanding these interactions can help unravel the mechanism of action of the LAMA2 protein in cells.

Customer Reviews (3)

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Reviews
12/04/2022

    LAMA2 has a wide range of applications and is suitable for a wide range of biological experiments.

    10/22/2021

      It is very qualitative, and it can maintain its structural and functional stability even after a lot of use, which shows its excellent quality and reliability.

      06/07/2021

        With high safety and high expression levels, it is ideal for laboratory and real-world applications.

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