LEF1
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Official Full Name
lymphoid enhancer-binding factor 1 -
Overview
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] -
Synonyms
LEF1;lymphoid enhancer-binding factor 1;LEF-1;TCF10;TCF7L3;TCF1ALPHA;TCF1-alpha;T cell-specific transcription factor 1-alpha
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- E. coli
- His
- Non
- GST
- Avi
- Fc
Involved Pathway
LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid cancer | RET,BRAF,MAPK1,PAX8,TPM3,CCND1,NTRK1,MAP2K1,MAPK3,TCF7L2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DAG1,ITGA8,AASS,CACNA2D4,ITGA1,SGCG,SGCB,ITGA6,CTNNA1,CTNNA3 |
| Pathways in cancer | LAMA4,GRB2,RASSF1,FZD6,ITGA6,FLT3LG,MAPK9,RXRA,WNT16,PTGER3 |
| Acute myeloid leukemia | MAP2K1,MYC,AKT3,TCF7,NFKB1,CCNA1,KRAS,MAPK1,PIM2,BRAF |
| Adherens junction | RAC1A,PTPRJA,PVRL1,RHOAD,WASF3B,PVRL3B,CTNND1,EP300,TGFBR2,WAS |
| Basal cell carcinoma | PTCH1,FZD8,SETD6,APC,WNT6,WNT9B,TRP53,FZD6,GLI3,BMP4 |
| Endometrial cancer | PIK3R5,PIK3R1,AKT2,AXIN1,MAP2K2,ILK,MAPK3,BRAF,AXIN2,TCF7L2 |
| Melanogenesis | KITA,ADCY1B,FZD8,KITB,KIT,GNA11A,FZD7A,TCF7L2,PRKACBB,FZD3B |
| Prostate Cancer | PDGFRA,NOXA1,HSP90AB1,CASP9,CCND1,MAPK1,FOXO1,PIK3R5,SPRY1,SPINK1 |
Protein Function
LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription regulatory region DNA binding | FOXA3,SNCA,DDIT3,WNT1,Arid4b,DLX5,ZNF821,PROX1,TFE3,ARRB1 |
| chromatin binding | ESR1,HMGB3,TFAM,HOXD10,SP110,EGFR,TRP53,POLD1,TP53,ARNTL1B |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GABPA,GMEB1,EGR2,AKNA,BSX,TLX1,CEBPG,ZFP292,CREB3,KLF13 |
| sequence-specific DNA binding | DBPA,LHX2,RXRGA,HOXC13B,ZBTB33,ZNF232,NKX1-2,HLF,SMAD3,TCF7L1B |
| transcription factor binding | HMGB1,TP73,PIAS1,ID1,FOXF2,SOX10,RELA,TCF7L2,ZFPM1,ZFPM2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CEBPE,NRF1,ZNF331,PATZ1,ZNF100,SKIL,BCL11B,SP1,ESR1,RFX5 |
| transcription factor activity, sequence-specific DNA binding | HIF1AL,CBFA2T2,TRPS1,ZNF45,KLF4,TEAD1,RXRBB,TARDBP,HOXB8,PKNOX1 |
| beta-catenin binding | BCL9L,PSEN1,TCF7L2,PTPRU,SALL1,AXIN1,CHD8,C,CXADR,DVL3 |
| estrogen receptor activity | ESR1,NKX3-1,ESR2A,GPR30,NKX3,ESR2,ESR2B |
Interacting Protein
LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1;IGF1R;TLE1;7242199;Hdac1;AURKA;BUB1;NRAS;RB1;MLH1;MSH2;BAX
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References
- Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).
- Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
