LEF1

  • Official Full Name

    lymphoid enhancer-binding factor 1

  • Overview

    This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

  • Synonyms

    LEF1;lymphoid enhancer-binding factor 1;LEF-1;TCF10;TCF7L3;TCF1ALPHA;TCF1-alpha;T cell-specific transcription factor 1-alpha

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • Non
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
LEF1-540H Recombinant Human LEF1, His-tagged E.coli Human His 1-399aa
LEF1-166H Recombinant Human LEF1 protein, His-tagged E.coli Human His
LEF1-3373R Recombinant Rat LEF1 Protein Mammalian Cells Rat His
LEF1-6571C Recombinant Chicken LEF1 Mammalian Cells Chicken His
LEF1-8995Z Recombinant Zebrafish LEF1 Mammalian Cells Zebrafish His
LEF1-9035M Recombinant Mouse LEF1 Protein Mammalian Cells Mouse His
LEF1-4778HCL Recombinant Human LEF1 293 Cell Lysate HEK293 Human Non
LEF1-301549H Recombinant Human LEF1 protein, GST-tagged E.coli Human GST Met1-Asp98
LEF1-3029R Recombinant Rat LEF1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
LEF1-3029R-B Recombinant Rat LEF1 Protein Pre-coupled Magnetic Beads HEK293 Rat
LEF1-4817H Recombinant Human LEF1 Protein (Glu45-His260), N-His tagged E.coli Human His Glu45-His260
LEF1-5032M Recombinant Mouse LEF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
LEF1-5032M-B Recombinant Mouse LEF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
LEF1-7687H Recombinant Human LEF1 protein, His-tagged E. coli Human His

    Involved Pathway

    LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acute myeloid leukemia RPS6KB2,PIM1,AKT1,FLT3,KIT,MAPK3,AKT2,KRAS,MAP2K1,PIK3R2
    Prostate Cancer ARAF,FOXO1,INS1,IKBKB,NOXA1,AKT2,MAPK1,PIK3CB,TRP53,TCF7L2
    Hippo signaling pathway GDF7,PARD6A,WNT2B,SMAD1,LATS2,YWHAG,GDF5,DVL3,BIRC2,WNT11
    Thyroid cancer KRAS,TPR,RXRB,TPM3,CCND1,RET,CCDC6,TFG,MAP2K2,TCF7
    Basal cell carcinoma FZD10,GLI3,WNT4,TP53,WNT10B,WNT7B,HHIP,GSK3B,APC2,WNT9A
    Colorectal cancer BRAF,SMAD4,PIK3R2,TGFB3,TCF7,APC,Casp3,MAPK10,MAPK9,BIRC5
    Wnt signaling pathway SMAD3,FZD2,RHOAC,SERPINF1,SFRP2,AXIN1,PRKACB,PRKACA,TBL1XR1,DKK2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) PKP2,EMD,ACTN4,DES,ACTB,DMD,CACNG1,CACNG4,CACNB3,ACTG1
    Endometrial cancer AKT1,MAP2K1,AXIN1,PIK3CA,PIK3R2,MAPK3,RAF1,PTEN,PIK3CD,ERBB2

    Protein Function

    LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.

    Function Related Protein
    armadillo repeat domain binding AXIN1,TCF7L2,STRN4,AXIN2,CALCOCO1,STRN,CTNNBIP1,CNOT1,CHD8
    protein binding CCDC70,STBD1,PTRH1,PPP2R2B,DDX18,DDRGK1,DAXX,TNNI3K,NR0B1,FGF3
    DNA binding, bending HMGB3,GATA1,HMGB1,FOXL1,TOP2B,FOXD4,CRIP1,TFAM,HMGB2,HMGA2
    gamma-catenin binding PTPRJ,Fert2,DSG1,CTNNA1,CDH2,FER,APC,PTBP3,PTPRK,CDH1
    DNA binding ZNF697,MYRFL,ZBTB44,SP110,OTX1B,HER1,ZKSCAN6,HOXD11A,MYCL1,ZNF254
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding FOXC2,THRA,SOX17,MYOG,GATA6,MEIS1,SPI1,POU3F3,RFX1,OLIG2
    C2H2 zinc finger domain binding TAF9,WT1,ZXDC,THAP7,EHMT2,GATA1,EBF1,EHMT1,U2AF2,GATA2
    transcription factor activity, sequence-specific DNA binding CEBPD,TBX2B,MEF2D,SOX11B,CNOT7,FOXH1,ZFP821,GTF2IRD1,BTBD8,NR1D1
    histone binding ASF1B,APBB1,PYGO2,ATAD2,USP3,WDTC1,SMARCA4A,HJURP,HIST1H3E,IPO7

    Interacting Protein

    LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.

    CTNNB1;IGF1R;TLE1;7242199;Hdac1;AURKA;BUB1;NRAS;RB1;MLH1;MSH2;BAX

    Resources

    Research Area

    References

    • Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).
    • Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All LEF1 Products

    Required fields are marked with *

    My Review for All LEF1 Products

    Required fields are marked with *