lef1
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  • Official Full Name
  • lymphoid enhancer-binding factor 1
  • Background
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
  • Synonyms
  • LEF1; lymphoid enhancer-binding factor 1; LEF-1; TCF10; TCF7L3; TCF1ALPHA; TCF1-alpha; T cell-specific transcription factor 1-alpha;
Cat.#:LEF1-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1 protein, His-tagged
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Cat.#:LEF1-540HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LEF1, His-tagged
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Cat.#:LEF1-9035MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LEF1 Protein
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Cat.#:LEF1-3373RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LEF1 Protein
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Cat.#:LEF1-6571CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LEF1
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Cat.#:LEF1-8995ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LEF1
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Cat.#:LEF1-4778HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LEF1 293 Cell Lysate
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Involved Pathway

LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
PRKCB; WNT8A; TBL1XR1; NKD2; WNT4; DVL3A; FZD8; WNT1; MYCB; RHOAB
Hippo signaling pathway
WNT7A; PPP2R2C; WNT7B; BMPR2; LATS2; TCF7L2; YWHAE; BMPR1A; YWHAG; BMP7
Adherens junction
WASF1; LMO7A; RAC3B; CDC42; PTPRB; ACTN2; LMO7; FARP2; EGFRA; INSR
Melanogenesis
DVL1B; ASIP; FZD10; CAMK2D2; FZD2; LEF1; MITFB; GNA11A; KITLGB; WNT5B
Pathways in cancer
LPAR5; RELA; GNG2; Casp3; AGTR1B; CXCL12; FN1; F2RL3; GLI3; TPR
Colorectal cancer
TRP53; BAD; MAPK10; PIK3CB; CASP9; TGFB1; SMAD3; RAF1; RAC3; PIK3R2
Endometrial cancer
RAF1; MAP2K1; HRAS; TP53; PIK3R3; PIK3CB; MAPK3; CASP9; KRAS; PIK3R2
Prostate cancer
PIK3R3; SOS1; IKBKB; IKBKG; PDGFB; AKT2; MDM2; MAPK1; PIK3CG; CREB5
Thyroid cancer
RXRB; MAPK3; MAPK1; KRAS; BRAF; RET; MAP2K1; CCND1; CDH1; TFG
Basal cell carcinoma
SETD6; WNT2B; Fzd4; GLI3; FZD1; LEF1; WNT6; SUFU; APC; WNT8A
Acute myeloid leukemia
RELA; RPS6KB1; PML; IKBKB; CCND1; FLT3; EIF4EBP1; RPS6KB2; PIK3R1; PIM1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGA1; CACNA2D3; ITGA2B; SGCD; ITGA4; ITGB8; ACTN2; ITGB7; SGCG; ITGAV

Protein Function

LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.
Function
Related Protein
Function C2H2 zinc finger domain binding
Related Protein EHMT2; LEF1; THAP7; EBF1; ZXDC; WT1; U2AF2; HMGA2; TAF9; GATA1
Function DNA binding
Related Protein ZNF445; ZNF726; ATF4B1; ZNF292A; ZFP422; ZEB2B; NR5A5; PDS5B; HIST1H47; REV3L
Function DNA binding, bending
Related Protein TOP2A; HMGB1; FOXL1; TERF1; HHEX; HMGA2; FOXI1; LEF1; SRY; TFAM
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ZFP746; HSF1; OTX1; NRL; GATA4; RFX5; RBPJB; JUNBA; ALS2CR8; ISL1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein ZNF583; CUX2; TBX5; FOXF1; ZFY2; ETV5; RUNX3; KAT2B; MEF2D; SP5
Function armadillo repeat domain binding
Related Protein CTNNBIP1; CNOT1; CHD8; STRN; TCF7L2; AXIN1; AXIN2; LEF1; STRN4; CALCOCO1
Function beta-catenin binding
Related Protein CBY1; SHROOM2; DVL3; CXADR; CARM1; CALCOCO1; SMAD7; TCF7L1B; SALL1; APC2
Function chromatin binding
Related Protein PROP1; SETD7; PPARG; BRD4; NR5A1B; ARX; Ar; FABP1; TFAM; MORF4L1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein XIAP; BIRC3; SERPINB1A; GAS6; IGF1RB; BIRC7; CD27; PRDX5; LEF1; SNCA
Function enhancer binding
Related Protein SP1; TIPARP; LEF1; SOX9; SMAD3; TCF12; FOXH1; MESP1; TCF3; ARNT
Function estrogen receptor activity
Related Protein LEF1; NKX3-1; ESR2A; GPR30; ESR2; NKX3; ESR1; ESR2B
Function estrogen receptor binding
Related Protein MED1; CTNNB1; WIPI1; FOXL2; PHB2; NSD1; ARRB1; DDX5; STRN; MMS19
Function gamma-catenin binding
Related Protein DSG1; CDH2; TCF7L2; PTPRJ; PTBP3; CTNNA1; APC2; FER; Fert2; LEF1
Function histone binding
Related Protein UHRF1; PRKCBB; HIST1H3C; H2AFX; HIST1H4B; NCL; DTX3L; ATRX; JAK2; BRD7
Function protein binding
Related Protein PSME3; EIF4G2; DDX39B; MRPS12; FIP1L1; HAND1; SLC1A1; STMN1; SNRPE; PVRL2
Function sequence-specific DNA binding
Related Protein ZFP161; RORC; ALX4B; NR2F5; NKX6-1; ZNF187; DLX2B; NKX6.1; HOXA1; THRA
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein GATA5; TEAD2; PAX3; T; BHLHE40; FOXC2; SOX7; TLE4; SNAI2; FOXF1
Function transcription factor activity, sequence-specific DNA binding
Related Protein SIX2; MYF6; ZNF483; NFIL3-6; ZNF43; NR2F1A; RELA; ZKSCAN1; RFX1A; NANOG
Function transcription factor binding
Related Protein PPP1R13L; GATA4; PARK7; IGHMBP2; DIP2BA; PAX6; GATA2; MYOD1; GTF2A1; PITX2
Function transcription regulatory region DNA binding
Related Protein FOXM1; AIRE; TFE3; ZFHX3; SALL1; TFAP2A; GATA6; TNF; STAT3; ATF3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SMAD2; DLX5; SOX9; GATA3; ZIC3; PITX3; MESP1; NFKB2; GCM1; CREB3L1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein SRF; GATA6; ATF3; EAF2; CEBPA; GATA2B; CREB3L4; ONECUT3; IKZF3; ALX1

Interacting Protein

LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.
CTNNB1; IGF1R; TLE1; 7242199; Hdac1; AURKA; BUB1; NRAS; RB1; MLH1; MSH2; BAX

LEF1 Related Articles

Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).
Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).