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LEO1

  • Official Full Name

    Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

  • Overview

    LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
  • Synonyms

    LEO1; Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); RDL; RNA polymerase-associated protein LEO1; replicative senescence down-regulated leo1-like protein;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LEO1-4774HCL Recombinant Human LEO1 293 Cell Lysate HEK293 N/A
Human LEO1-2081HFL Recombinant Full Length Human LEO1 Protein, C-Flag-tagged Mammalian cells Flag
Human LEO1-5824H Recombinant Human LEO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LEO1-1288H Recombinant Human LEO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LEO1-1288H-B Recombinant Human LEO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse LEO1-9047M Recombinant Mouse LEO1 Protein Mammalian Cell His
Mouse LEO1-5040M Recombinant Mouse LEO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LEO1-5040M-B Recombinant Mouse LEO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Leo1-3774M Recombinant Mouse Leo1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat LEO1-3375R Recombinant Rat LEO1 Protein Mammalian Cell His
Rat LEO1-3031R Recombinant Rat LEO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LEO1-3031R-B Recombinant Rat LEO1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LEO1-11799Z Recombinant Zebrafish LEO1 Mammalian Cell His
Chicken LEO1-5518C Recombinant Chicken LEO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LEO1 Related Articles
  • LEO1 Related Research Area

LEO1 involved in several pathways and played different roles in them. We selected most pathways LEO1 participated on our site, such as Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Formation of the beta-catenin:TCF transactivating complexCDC73;BCL9;TLE2;PYGO1;SMARCA4;RBBP5;TLE3;PYGO2;LEO1
Signal TransductionGPBAR1;STARD13;CDC42EP3;TAX1BP1B;FABP11B;CRABP2B;AMOTL2;MKS1;FAM13B1
Signaling by WntKREMEN1;SRY;TLE3B;TMED5;WLS;KREMEN2;HECW1;WNT8-2;CDC73
TCF dependent signaling in response to WNTLGR6;TNKS;DACT1;USP34;LGR5;WNT8-2;HECW1;SOX4A;RNF146

LEO1 has several biochemical functions, for example, RNA polymerase II C-terminal domain phosphoserine binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEO1 itself. We selected most functions LEO1 had, and list some proteins which have the same functions with LEO1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II C-terminal domain phosphoserine binding
protein bindingTET3;PYGL;IRF5;FBXO46;CNNM3;TRIM54;COL8A1;CD177;VAPB

LEO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEO1.

PAF1

Chong, PSY; Zhou, JB; et al. LEO1 Is Regulated by PRL-3 and Mediates Its Oncogenic Properties in Acute Myelogenous Leukemia. CANCER RESEARCH 74:3043-3053(2014).
Wang, JC; Dixon, SE; et al. Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation. PLOS PATHOGENS 10:-(2014).
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