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LEPRE1

  • Official Full Name

    leucine proline-enriched proteoglycan (leprecan) 1

  • Overview

    This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined.
  • Synonyms

    LEPRE1; leucine proline-enriched proteoglycan (leprecan) 1; prolyl 3-hydroxylase 1; GROS1; growth suppressor 1; LEPRECAN; MGC117314; P3H1; prolyl 3 hydroxylase 1; leucine- and proline-enriched proteoglycan 1; OI8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LEPRE1-29940TH Recombinant Human LEPRE1, His-tagged E.coli His
Human LEPRE1-4772HCL Recombinant Human LEPRE1 293 Cell Lysate HEK293 N/A
Human LEPRE1-2692H Recombinant Human LEPRE1 protein, His-tagged E.coli His 23-109 aa
Mouse LEPRE1-9050M Recombinant Mouse LEPRE1 Protein Mammalian Cell His
Mouse LEPRE1-5043M-B Recombinant Mouse LEPRE1 Protein Pre-coupled Magnetic Beads HEK293
Mouse LEPRE1-5043M Recombinant Mouse LEPRE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LEPRE1-3377R Recombinant Rat LEPRE1 Protein Mammalian Cell His
Rat LEPRE1-3033R Recombinant Rat LEPRE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LEPRE1-3033R-B Recombinant Rat LEPRE1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LEPRE1-2498R Recombinant Rhesus monkey LEPRE1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LEPRE1-2319R-B Recombinant Rhesus Macaque LEPRE1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LEPRE1-2319R Recombinant Rhesus Macaque LEPRE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken LEPRE1-1119C Recombinant Chicken LEPRE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LEPRE1 Related Articles

LEPRE1 involved in several pathways and played different roles in them. We selected most pathways LEPRE1 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPRE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Collagen biosynthesis and modifying enzymesCOL1A2;COL6A3;COL10A1A;COL8A1;COL2A1;BMP1;LEPREL2;EMID2;COL9A1B
Collagen formationPRP;SERPINH1;COL28A1;PCOLCEA;TLDC2;COL16A1;ABHD1;COL17A1A;COL10A1A
Extracellular matrix organizationCOL4A3;FAM49BA;BSG;COL1A1;COL13A1;TIMP2;PCOLCEB;COL19A1;COL9A1A

LEPRE1 has several biochemical functions, for example, L-ascorbic acid binding, contributes_to collagen binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPRE1 itself. We selected most functions LEPRE1 had, and list some proteins which have the same functions with LEPRE1. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingP4HA1A;EGLN2;DBH;P3H2;P4HA2;FAM125B;LEPRE1;OGFOD2;EGLN3
contributes_to collagen bindingLEPRE1;PPIB
iron ion bindingCYP46A1.2;CYP19A1;CYP2Y3;XDH;AOX3L1;CYP4X1;CYP3A7;CYP1B1;CYP2N13
molecular_functionECRG4A;TMEM144A;TMEM188;CCDC46;FAM3A;TSPAN3;PBDC1;FAM154B;PRL3C1
procollagen-proline 3-dioxygenase activityP3H2;LEPRE1;LEPREL2;LEPREL1
protein complex bindingC8B;RXRA;FBN1;PPIB;NSF;PGAM5;RIPK3;Cel;RAP1A

LEPRE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPRE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPRE1.

Sf3a1; WDR48; Mtx1; SEC16A; NUDT21; KIF21B; VPS26A; MED26; MYC; cona_canen; Sod1; H2AFX; SNCA; CDK18; RNPS1; Srsf1; Smad3; CEP170P1; MAP1LC3B; Sart3

Rauch, F; Lalic, L; et al. Targeted Sequencing of a Pediatric Metabolic Bone Gene Panel Using a Desktop Semiconductor Next-Generation Sequencer. CALCIFIED TISSUE INTERNATIONAL 95:323-331(2014).
Rubinato, E; Morgan, A; et al. A novel deletion mutation involving TMEM38B in a patient with autosomal recessive osteogenesis imperfecta. GENE 545:290-292(2014).
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