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LIMK1

  • Official Full Name

    LIM domain kinase 1

  • Overview

    There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
  • Synonyms

    LIMK1; LIM domain kinase 1; LIMK; LIMK-1; LIM motif-containing protein kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIMK1-1029H Active Recombinant Human LIMK1, GST-tagged Sf9 Insect Cell GST
Human LIMK1-1542H Active Recombinant human LIMK1, GST-tagged Sf9 Insect Cell GST
Human LIMK1-123H Active Recombinant Human LIMK1(285-638) Protein, N-His-tagged Sf21 His 285-638 aa
Human LIMK1-124H Unactive Recombinant Human LIMK1(285-638) Protein, N-His-tagged Sf21 His 285-638 aa
Human LIMK1-29945TH Recombinant Human LIMK1 N/A
Human LIMK1-321H Recombinant Human LIMK1 protein, GST-tagged Wheat Germ GST
Human LIMK1-131H Recombinant Human LIMK1, GST-tagged Sf9 Insect Cell GST
Human LIMK1-531H Recombinant Human LIMK1 Mammalian Cell His
Human LIMK1-4739HCL Recombinant Human LIMK1 293 Cell Lysate HEK293 N/A
Human LIMK1-3693H Recombinant Human LIMK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LIMK1-1176H Recombinant Human LIMK1 Protein (R329-G638), Tag Free Insect Cell No tag R329-G638
Human LIMK1-675HF Recombinant Full Length Human LIMK1 Protein, GST-tagged In Vitro Cell Free System GST 647 amino acids
Human LIMK1-39H Recombinant Human LIMK1 Protein (285-638), N-GST tagged Sf9 Insect Cell N-GST 285-638
Human LIMK1-1177H Recombinant Human LIMK1 Protein (R329-G638), His tagged Insect Cell His R329-G638
Mouse LIMK1-9108M Recombinant Mouse LIMK1 Protein Mammalian Cell His
Mouse LIMK1-5085M Recombinant Mouse LIMK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Limk1-1320M Recombinant Mouse Limk1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse LIMK1-5085M-B Recombinant Mouse LIMK1 Protein Pre-coupled Magnetic Beads HEK293
Chicken LIMK1-5707C Recombinant Chicken LIMK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIMK1 Related Articles
  • LIMK1 Related Signal Pathway

LIMK1 involved in several pathways and played different roles in them. We selected most pathways LIMK1 participated on our site, such as Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceMYL12A;COL4A5;MAPK1;SEMA6D;SRGAP3;ANK2B;ROCK2;FGF20A;PPP3CB
Fc gamma R-mediated phagocytosisWASL;ASAP2;PRKCE;AMPH;INPPL1;WAS;MYO10;MAPK3;AKT1
Regulation of actin cytoskeletonRAC1A;INSB;WASL;RAC3B;ITGA9;RHOAA;CDC42L2;FGF19;WASF1

LIMK1 has several biochemical functions, for example, ATP binding, heat shock protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMK1 itself. We selected most functions LIMK1 had, and list some proteins which have the same functions with LIMK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTRP53;HSPA4B;UBE2R2;BLM;RET;ATP1A3B;PDXK;MAPK8A;C10orf2
heat shock protein bindingDNAJA2;TFAM;DLST;BAK1;HSPA1L;TOMM34;DAXX;IRAK1;DMPK
protein bindingSCNN1G;LSM11;RPGR;POLR1C;PTPN23;MVP;FGFR3;TTC35;TTR
protein heterodimerization activityUNC13A;PRMT5;CLCF1;TAF9B;HIST1H2BD;KATNA1;Fzd4;SRI;H2-AB1
protein kinase activityCASKA;RPS6KB1B;GRK1;PLK5;CSNK1DB;ROCK2A;NPR1;PRKCZ;OXSR1B
protein serine/threonine kinase activityMAPK12B;MAP4K4;DYRK4;ERN1;CAMK2G1;PDPK1;TAF1;STK30;CIT
zinc ion bindingDBF4;RNF114;C11orf54;RFWD2;RYBPA;CXXC5;USP20;RABGGTB;RORA

LIMK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMK1.

SSH1; PAK1; LATS1; PAK2; Arrb1

Li, S; Leshchyns'ka, I; et al. The Neural Cell Adhesion Molecule (NCAM) Associates with and Signals through p21-Activated Kinase 1 (Pak1). JOURNAL OF NEUROSCIENCE 33:790-+(2013).
Davies, AH; Barrett, I; et al. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. ONCOGENE 30:3649-3660(2011).
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