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LMAN2

  • Official Full Name

    lectin, mannose-binding 2

  • Overview

    This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control.
  • Synonyms

    LMAN2; lectin, mannose-binding 2; C5orf8, chromosome 5 open reading frame 8; vesicular integral-membrane protein VIP36; GP36B; VIP36; glycoprotein GP36b; vesicular integral protein of 36 kDa; vesicular integral-membrane protein 36; C5orf8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • HIS
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LMAN2-6979H Recombinant Human LMAN2 protein, His-tagged E.coli His Asp45-Arg322
Human LMAN2-053H Recombinant Human LMAN2 Protein, HIS-tagged HEK293 HIS
Human LMAN2-4718HCL Recombinant Human LMAN2 293 Cell Lysate HEK293 N/A
Human LMAN2-3945H Recombinant Human LMAN2 Protein (Asp45-Arg322), C-His tagged Mammalian cells C-His Asp45-Arg322
Human LMAN2-3947H Recombinant Human LMAN2 Protein (Asp45-Arg322), N-His tagged E.coli N-His Asp45-Arg322
Mouse LMAN2-9144M Recombinant Mouse LMAN2 Protein Mammalian Cell His
Mouse Lman2-3797M Recombinant Mouse Lman2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse LMAN2-5109M Recombinant Mouse LMAN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LMAN2-5109M-B Recombinant Mouse LMAN2 Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL26083CF Recombinant Full Length Dog Vesicular Integral-Membrane Protein Vip36(Lman2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (45-356)
Zebrafish LMAN2-5201Z Recombinant Zebrafish LMAN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LMAN2 Related Articles

LMAN2 involved in several pathways and played different roles in them. We selected most pathways LMAN2 participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMAN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationTRAPPC1;MAN1B1;OS9;ST8SIA3;DAD1;SEC24A;GNE;PPP6R1;SERPINA1L
COPII (Coat Protein 2) Mediated Vesicle TransportTRAPPC2L;TRAPPC5;PREB;TRAPPC6A;MCFD2;NAPAA;SEC24A;GOLGA2;PPP6R3
Cargo concentration in the ERSERPINA1L;AREG;CTSC;LMAN2;PREB;MCFD2;CNIH2;TMED10;CTSZ
ER to Golgi Anterograde TransportSEC16B;ANKRD28;LMAN2;PREB;NAPB;CNIH3;TRAPPC4;TRAPPC2L;SEC22A
Membrane TraffickingNSFB;HIP1RB;AP4B1;CNIH3;TMED2;EXOC3;BLOC1S3;RALAB;TRAPPC10
Metabolism of proteinsSCFD1;PFDN2;SFTPB;DOHH;FBXL5;ST3GAL3A;PAPPA2;MBOAT4;IGFBP2B
Post-translational protein modificationMPDU1B;PHC2;ZNF408;TFG;TRAPPC6BL;NAPG;ARSJ;NAPB;NEU3
Protein processing in endoplasmic reticulumBAX;EIF2S1B;PDIA3;HSPA1B;NFE2L2;SAR1A;PARK2;MAN1A2;UBE2D3

LMAN2 has several biochemical functions, for example, carbohydrate binding, glycoprotein binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMAN2 itself. We selected most functions LMAN2 had, and list some proteins which have the same functions with LMAN2. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingGALNTL1;PVRL1;CLEC9A;LMAN2;CD34;KLRA8;POC1BL;SIGLEC10;CHI3L2
glycoprotein bindingITGAM;THBS1;VWF;SERPINA1A;IDE;HSPA5;BMPR1B;ACE2;VLDLR
heat shock protein bindingDLST;BCOR;DNAJA3A;NFKB1;HDAC2;APAF1;TFAM;KCNJ11;DNAJA3B
mannose bindingMBL2;CLN5;COLEC10;DPM1;CD209B;CD209C;IGF2R;MAN2B1;CD209A
metal ion bindingCYP21A1;RPS6KAL;RPL37A;ACSM2;NAIP7;ZNF596;TGM5;KLF2B;ATP1A1B

LMAN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMAN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMAN2.

env; SUPT5H; MAPK9; FRAT1; ATP13A2; 15-deoxy-delta(12,14; 1C; env; P

Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).
Ribeiro, CH; Lynch, NJ; et al. Deficiency in Mannose-Binding Lectin-Associated Serine Protease-2 Does Not Increase Susceptibility to Trypanosoma cruzi Infection. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 92:320-324(2015).
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