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LOXL1

  • Official Full Name

    lysyl oxidase-like 1

  • Overview

    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
  • Synonyms

    LOXL1; lysyl oxidase-like 1; LOL; LOXL; lysyl oxidase homolog 1; lysyl oxidase-like protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LOXL1-149H Recombinant Human LOXL1, GST-tagged Sf9 Insect Cell GST
Human LOXL1-1028HCL Recombinant Human LOXL1 cell lysate N/A
Human LOXL1-2696H Recombinant Human LOXL1 protein, His-tagged E.coli His 283-366 aa
Human LOXL1-3182H Recombinant Human LOXL1 protein E.coli N/A 95-574aa
Human LOXL1-3181H Recombinant Human LOXL1 protein, His-tagged E.coli His 106-574aa
Human LOXL1-4732H Recombinant Human LOXL1 Protein, GST-tagged Wheat Germ GST
Human LOXL1-5964HF Recombinant Full Length Human LOXL1 Protein, GST-tagged In Vitro Cell Free System GST 574 amino acids
Human LOXL1-268H Recombinant Human LOXL1 Protein, His-tagged E.coli His Leu369~Ser574
Human LOXL1-28H Recombinant Human LOXL1 Protein, T7-His-tagged E.coli T7/His
Mouse LOXL1-9185M Recombinant Mouse LOXL1 Protein Mammalian Cell His
Mouse LOXL1-5131M Recombinant Mouse LOXL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LOXL1-1446M Recombinant Mouse LOXL1 Protein (95-607 aa), His-tagged Yeast His 95-607 aa
Mouse Loxl1-270M Recombinant Mouse Loxl1 Protein, His-tagged E.coli His Val392~Ser598
Mouse LOXL1-5131M-B Recombinant Mouse LOXL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse LOXL1-629M Recombinant Mouse LOXL1 Protein (95-607 aa), His-tagged E.coli His 95-607 aa
Rat Loxl1-271R Recombinant Rat Loxl1 Protein, His-tagged E.coli His Val393~Cys603
Zebrafish LOXL1-3850Z Recombinant Zebrafish LOXL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LOXL1 Related Articles
  • LOXL1 Related Research Area

LOXL1 involved in several pathways and played different roles in them. We selected most pathways LOXL1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of collagen fibrils and other multimeric structuresPCOLCE;MMP13;LOXL2;COL10A1A;CTSB;COL4A3;COL8A1;TLL1;COL4A4
Collagen formationCOL4A5;COL5A3A;COL8A2;LOXL3;COL17A1A;COL4A3;COL2A1;PCOLCEB;COL6A3
Crosslinking of collagen fibrilsLOXL4;PCOLCE;BMP1A;ABHD1;LOXL2;BMP1B;LOXL3;TLL2;LOXL1
Elastic fibre formationBMP10;LOXL2;LTBP3;EFEMP2;MFAP2;FBN2;FBN1;ABHD1;LTBP4
Extracellular matrix organizationMMP10;COL6A3;COMP;PCOLCE2B;COL9A3;PCOLCEB;LRP4;COL28A1D;DMP1

LOXL1 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL1 itself. We selected most functions LOXL1 had, and list some proteins which have the same functions with LOXL1. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingMT3;DBH;AOC1;LOXL1;ABHD1;MOXD2;COX17;LOXL5A;P2RX2
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptorLOXL1;LOXL2A;LOXL5B;LOXL3B;LOXL2B;LOXL5A;LOXL3A

LOXL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL1.

FBLN5; GATAD2B; TFAP2A; ATXN1; TFAP2C

Creasey, R; Sharma, S; et al. Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in Pseudoexfoliation Syndrome. ULTRAMICROSCOPY 111:1055-1061(2011).
Kumarasamy, A; Schmitt, I; et al. Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human Lungs. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:1239-1252(2009).
Fujimoto, E; Tajima, S; et al. Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 55:91-98(2009).
Pascual, G; Mendieta, C; et al. Down-regulation of lysyl oxydase-like in aging and venous insufficiency. HISTOLOGY AND HISTOPATHOLOGY 23:179-186(2008).
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