LPA

  • Official Full Name

    lipoprotein, Lp(a)
  • Overview

    Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophage white blood cells and promoted by low-density lipoproteins (plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high density lipoproteins (HDL), (see apoA-1 Milano). It is commonly referred to as a hardening or furring of the arteries. It is caused by the formation of multiple plaques within the arteries.
  • Synonyms

    Oxidized Lipoprotein (a);Oxidized Lp (a);Lipoprotein(a) Oxidized-Lp(a);Oxidized Lipoprotein;LPA
Cat.# Product name Source (Host) Species Tag Protein Length Price
LPA-8453H Native Human LPA Human Plasma Human Non
LPA-7813H Recombinant Human LPA protein, His-tagged E.coli Human His Asp1719~Arg2038
LPA-352L Native Legionella Pneumophila Antigen Protein LP LP Non
LPA-8454H Native Human lipoprotein Lp(a) Serum Human Non

    Involved Pathway

    LPA involved in several pathways and played different roles in them. We selected most pathways LPA participated on our site, such as LDL-mediated lipid transport,Lipid digestion, mobilization, and transport,Lipoprotein metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    amb2 Integrin signaling MST1,HP,ELANE,MST1R,NIPAL1,CYR61
    Metabolism of lipids and lipoproteins ARF3,SLC25A1,PPM1L,FABP9,CRAT,NEU4,ARSK,FA2H,SCP2B,YY2
    LDL-mediated lipid transport APOF,CETP,APOBB.1
    Metabolism ACOT8,TYMP,CHP,NEU3,MAPK1IP1L,ARL2,AWAT1,PDK2,PTPMT1,CTRC
    Lipid digestion, mobilization, and transport APOA4B.2,APOA5,FABP11B,LMF1,APOA4B.1,FABP11A,ABCA1,FABP9,Alb,APOA1B
    Lipoprotein metabolism APOA5,APOC2,APOA4B.1,APOA4A,APOBB.1,APOA1B,CETP,APOEA,APOF,Alb

    Protein Function

    LPA has several biochemical functions, for example, apolipoprotein binding,endopeptidase inhibitor activity,fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPA itself. We selected most functions LPA had, and list some proteins which have the same functions with LPA. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activity GZMB,KLK1B9,FURIN,KLK1B1,HTRA1A,KLK1B4,PCSK9,PRSS23,C2,PREPL
    apolipoprotein binding ABCA1,MAPT,LRP1,SCARB1,LIPC,CANX,LRP6,LRP4,PLG,PCSK9
    heparin binding UBE4A,GREM2,MSTN,FMOD,FGF2,WISP1,FGFR1A,ANG,ELANE,ADAMTSL5
    fibronectin binding FSTL3,CTGF,ITGAV,IGFBP3,ITGA3,SFRP2,LACRT,FBLN1,IGFBP5A,THBS1
    protein binding SNX19,MBD3,ATP6V1D,NOSIP,PRKCE,DPEP3,CDKN1B,LSM7,SEC23IP,BIRC7
    endopeptidase inhibitor activity SERPINA1D,CST3,SLPI,USP14,C5,WFDC2,UCHL5,CAST,Hc,ITIH2

    Interacting Protein

    LPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPA here. Most of them are supplied by our site. Hope this information will be useful for your research of LPA.

    APOH;FN1

    Resources

    References

    • Leblanc, R; Lee, SC; et al. Interaction of platelet-derived autotaxin with tumor integrin alpha(V)beta(3) controls metastasis of breast cancer cells to bone. BLOOD 124:3141-3150(2014).
    • Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).

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