LRPPRC

  • Official Full Name

    leucine-rich pentatricopeptide repeat containing

  • Overview

    This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

  • Synonyms

    LRPPRC;leucine-rich pentatricopeptide repeat containing;LSFC;GP130;LRP130;CLONE-23970;leucine-rich PPR motif-containing protein, mitochondrial;LRP 130;130 kDa leucine-rich protein;leucine-rich PPR-motif containing;mitochondrial leucine-rich PPR motif-containing protein

Recombinant Proteins

  • Rat
  • Zebrafish
  • Mouse
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • GST
  • DDK
  • Myc

    Involved Pathway

    LRPPRC involved in several pathways and played different roles in them. We selected most pathways LRPPRC participated on our site, such as Gene Expression,Generic Transcription Pathway,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    The citric acid (TCA) cycle and respiratory electron transport NDUFAF6,SURF1,PDK3,ETFDH,PDP2,ETFA,MPC1,NDUFAF7,COX14,ETFB
    Metabolism NDUFAF2,DDAH2,EBP,ARL2BP,CYP2K22,OMD,SLC35D1A,GNG13B,EPM2A,GRX2
    TP53 Regulates Metabolic Genes PRDX2,FAM36A,TACO1,COX14,SESN3,SCO1,COX18,SURF1,COX16
    TNF-alpha/NF-kB Signaling Pathway COPS3,RNF25,TRPC4AP,DPF2,USP2,PAPOLA,NKIRAS1,TXLNA,G3BP2,PDCD2
    Generic Transcription Pathway ZNF79,ZNF37A,TACO1,NR1I2,ZNF565,KRBOX4,PPARAA,ZNF266,ZNF398,RARAB
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. TIMMDC1,NDUFAF3,NDUFAF7,ETFA,UCP2,COX14,ATP5S,C20orf7,NDUFAF4,NDUFAF5
    Respiratory electron transport C20orf7,FAM36A,TACO1,NDUFAF4,ETFA,NDUFAF5,COX14,TIMMDC1,COX18,COX16
    Gene Expression TYW3,ZNF202,ZNF668,TRMT61A,ZNF311,C2orf29,ZNF446,DARS,ZNF18,DDX20

    Protein Function

    LRPPRC has several biochemical functions, for example, RNA binding,NOT actin filament binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPPRC itself. We selected most functions LRPPRC had, and list some proteins which have the same functions with LRPPRC. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GABRG2,RGS6,CLEC1B,CLCN1,PTS,ERP44,TET2,RECK,TRIP6,MRPS23
    NOT actin filament binding MAP1S,UXT
    beta-tubulin binding OST4,GABARAP,GABARAPL1,GABARAPL2,CASC1,AKAP1,RACGAP1,VAPB,PDCD5,PEX14
    ubiquitin protein ligase binding CUL2,GABARAP,CASC3,UBE2NB,ERBB2,GLMN,POLR2A,RELA,H2-AB1,AURKA
    single-stranded DNA binding SSBP2,NABP2,ANXA1,RPA3,RAD51C,CSDA,RAD51L1,SSBP4,NEIL3,HNRNPK
    RNA binding Akap17b,PTBP1,HNRNPR,PUS7L,HNRNPF,DAZL,ZFML,PCBP3,RPLP2,NOL9
    poly(A) RNA binding YARS,ZFP598,ARCN1,FKBP4,HIST1H4I,DCD,MRPL14,PRPF4B,RPL35,MRPL11
    microtubule binding TRPV4,MAP205,MTUS2,PLK1,CHD4,GLI1,APC,KIF3B,SYBU,NEFH

    Interacting Protein

    LRPPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPPRC.

    MYC;EIF4E;SLIRP;PPARGC1A;vpu;7242199;Ppargc1a

    Resources

    References

    • Baggio, F; Bratic, A; et al. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. NUCLEIC ACIDS RESEARCH 42:13920-13938(2014).
    • Zhou, JY; Zhang, FH; et al. Downregulation of LRPPRC Induces Apoptosis in Prostate Cancer Cells Through the Mitochondria-Mediated Pathway. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 29:345-350(2014).

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