LRPPRC
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Official Full Name
leucine-rich pentatricopeptide repeat containing -
Overview
This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012] -
Synonyms
LRPPRC;leucine-rich pentatricopeptide repeat containing;LSFC;GP130;LRP130;CLONE-23970;leucine-rich PPR motif-containing protein, mitochondrial;LRP 130;130 kDa leucine-rich protein;leucine-rich PPR-motif containing;mitochondrial leucine-rich PPR motif-containing protein
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
- Flag
- GST
- DDK
- Myc
Involved Pathway
LRPPRC involved in several pathways and played different roles in them. We selected most pathways LRPPRC participated on our site, such as Gene Expression,Generic Transcription Pathway,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| The citric acid (TCA) cycle and respiratory electron transport | ETFA,UCP2,ATP5S,PDK3,NDUFAF5,NDUFAF6,COX14,NDUFAF3,PDK4,SLC25A27 |
| Gene Expression | ZKSCAN5,COX11,ZNF71,ZNF3,ZNF486,MBD3A,EEF1D,DARS,ZNF684,DDX6 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | SURF1,NDUFAF5,TIMMDC1,ATP5S,ETFDH,ETFB,COX14,C2orf56,TACO1,C20orf7 |
| TNF-alpha/NF-kB Signaling Pathway | PAPOLA,TRAIP,CRADD,KIAA1967,KPNA6,COMMD1,DPF2,UNC5CL,ZFAND5,COPS3 |
| Metabolism | AKR1C21,DPYS,PDPR,COX7C,SULT2ST1,OAZ1,CYP3A7,CYP2K22,MPC1,OSBP |
| Respiratory electron transport | TACO1,SCO1,NDUFAF2,NDUFAF7,C2orf56,COX11,ETFDH,COX18,COX16,COX14 |
| Generic Transcription Pathway | MED20,ZNF205,NR2E1,ZNF266,ZNF710,ZNF468,ZNF658,ZIM2,ZIM3,ZNF697 |
| TP53 Regulates Metabolic Genes | TACO1,SCO1,SURF1,COX18,COX16,FAM36A,SESN3,PRDX2,COX14 |
Protein Function
LRPPRC has several biochemical functions, for example, RNA binding,NOT actin filament binding,beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPPRC itself. We selected most functions LRPPRC had, and list some proteins which have the same functions with LRPPRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| single-stranded DNA binding | BLM,HMGB2,DMC1,ERCC5,SSBP3B,NUP35,RAD51,SSBP4,NCL,SWSAP1 |
| NOT actin filament binding | MAP1S,UXT |
| protein binding | TMEM11,PARP4,CDC40,PLG,ARVCF,CD1d1,TCP1,EXOSC5,HNRNPUL1,MRPL13 |
| ubiquitin protein ligase binding | ERLIN2,PRKACB,DNM1L,CUL4B,UBE2G1,PTPN22,TSG101,GSK3B,SNCAIP,NPLOC4 |
| beta-tubulin binding | TRPV4,CASC1,PACRG,SERPINB1A,OST4,IFT74,RGS2,HDAC6,ADNP,RANBP10 |
| microtubule binding | KIF9,KCNH2A,WDR43,KIF3C,KLC3,GAS2L3,ARHGEF2,FNTA,MAP4,EML2 |
| poly(A) RNA binding | MRPL1,NPM1,CCDC86,ABCF1,RPS8,MRPL28,TRMT6,STIP1,FYTTD1,YTHDF2 |
| RNA binding | RPL19,ENDOU,EIF2S1B,FARSB,RPLP2,CNOT4B,DDX3Y,DUSP11,IFIT10,EIF4E2RS1 |
Interacting Protein
LRPPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPPRC.
MYC;EIF4E;SLIRP;PPARGC1A;vpu;7242199;Ppargc1a
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References
- Baggio, F; Bratic, A; et al. Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. NUCLEIC ACIDS RESEARCH 42:13920-13938(2014).
- Zhou, JY; Zhang, FH; et al. Downregulation of LRPPRC Induces Apoptosis in Prostate Cancer Cells Through the Mitochondria-Mediated Pathway. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 29:345-350(2014).
