LRSAM1

  • Official Full Name

    leucine rich repeat and sterile alpha motif containing 1

  • Overview

    This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways;and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis.;Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding;different isoforms have been identified for this gene.

  • Synonyms

    LRSAM1;leucine rich repeat and sterile alpha motif containing 1;E3 ubiquitin-protein ligase LRSAM1;FLJ31641;E3 ubiquitin protein ligase LRSAM1;EC 6.3.2.-;hTAL;Leucine rich repeat and sterile alpha motif containing protein 1;OTTHUMP00000022174;OTTHUMP00000022175;RIFLE;TAL;Tsg101 associated ligase;Tsg101-associated ligase;leucine-rich repeat and sterile alpha motif-containing protein 1

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • HEK293
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • DDK
  • Myc
  • His
  • Non
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
LRSAM1-2342H Recombinant Human LRSAM1 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
LRSAM1-29433TH Recombinant Human LRSAM1, His-tagged E.coli Human His 491-723 a.a.
LRSAM1-5811Z Recombinant Zebrafish LRSAM1 Mammalian Cells Zebrafish His
LRSAM1-1036HCL Recombinant Human LRSAM1 cell lysate Human Non
LRSAM1-1702H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
LRSAM1-2558H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
LRSAM1-2794H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Lrsam1-3847M Recombinant Mouse Lrsam1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
LRSAM1-4624H Recombinant Human LRSAM1 Protein, GST-tagged Wheat Germ Human GST
LRSAM1-6111HF Recombinant Full Length Human LRSAM1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 723 amino acids

    Involved Pathway

    LRSAM1 involved in several pathways and played different roles in them. We selected most pathways LRSAM1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRSAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    presentation TRIM11,UBE2V2,UBE2E3,MKRN1,ASB17,CTSS,SPSB2,FBXO27,ERAP2,RNF123
    Adaptive Immune System KIF26A,SLAMF6,KIF3A,IGLC2,RAET1E,CD200,ASB14,KIF3C,B2ML,Siglece
    Immune System TRIM22,TRIM46,EIF4E3,RACGAP1,EDAR,LILRA1,HCST,UBA5,KIR2DS2,DYNC1I2
    Antigen processing: Ubiquitination &amp ASB8,RNF144B,CMTM2A,PJA2,KLHL21,ASB4,ASB2,RNF182,UFL1,HUWE1
    Class I MHC mediated antigen processing &amp B2ML,FBXO27,FBXO17,ASB8,LTN1,TRAF7,TRIM9,TRIM69,SPSB4,TRIM63
    Proteasome degradation STUB1,ASB8,ARIH2,RNF182,VPRBP,RNF19B,RNF111,UBR2,SPSB1,TRIM9

    Protein Function

    LRSAM1 has several biochemical functions, for example, hormone activity,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRSAM1 itself. We selected most functions LRSAM1 had, and list some proteins which have the same functions with LRSAM1. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity HERC6,UBE2KB,RNF4,UBE3A,PARK2,UBE1Y1,TMEM129,RNF6,SHRPRBCK1R,HUWE1
    ubiquitin protein ligase activity UBR1,RNF144AA,UBE2S,MSL2,CDC42,BRAP,UBE3A,SIAH1A,MED21,TRIM59
    zinc ion binding POLR1A,ATXN7L3,RNF34A,BRF1B,RNF113A,RNF121,DTNA,ZNF207,CECR1,XAF1
    ubiquitin-protein transferase activity KLHL20,FBXL21,MARCH2,CDC23,RNF125,FEM1B,UBE3C,RNF144AA,RFWD3,FBXL6
    hormone activity PRL7B1,NPPB,INHBB,GPHB5,NPPC,UCN2,INSL5A,STC2A,IGF2B,UTS2A
    protein binding HSPG2,FGFR4,ILK,DCP1A,SPTLC1,RNF185,TIPIN,COPS2,TOM1L1,CHID1

    Interacting Protein

    LRSAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRSAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRSAM1.

    TSG101;UBE2N;TERF1;UBA1;UBE2V1;HSP90AB1;HIP2;TNFRSF10C;MDM4;ATXN7;MYL2;RXRG;UBE2D1

    Resources

    References

    • Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).

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