| Description : |
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
83.6 kDa |
| AA Sequence : |
MPLFFRKRKPSEEARKRLEYQMCLA KEAGADDILDISKCELSEIPFGAFA TCKVLQKKVLIVHTNHLTSLLPKSC SLLSLATIKVLDLHDNQLTALPDDL GQLTALQVLNVERNQLMQLPRSIGN LTQLQTLNVKDNKLKELPDTVGELR SLRTLNISGNEIQRLPQMLAHVRTL EMLSLDASAMVYPPREVCGAGTAAI LQFLCKESGLEYYPPSQYLLPILEQ DGIENSRDSPDGPTDRFSREELEWQ NRFSDYEKRKEQKMLEKLEFERRLE LGQREHTQLLQQSSSQKDEILQTVK EEQSRLEQGLSEHQRHLDAERQRLQ EQLKQTEQNISSRIQKLLQDNQRQK KSSEILKSLENERIRMEQLMSITQE ETESLRRRDVASAMQQMLTESCKNR LIQMAYESQRQNLVQQACSSMAEMD ERFQQILSWQQMDQNKAISQILQES AMQKAAFEALQVKKDLMHRQIRSQI KLIETELLQLTQLELKRKSLDTESL QEMISEQRWALSSLLQQLLKEKQQR EEELREILTELEAKSETRQENYWLI QYQRLLNQKPLSLKLQEEGMERQLV ALLEELSAEHYLPIFAHHRLSLDLL SQMSPGDLAKVGVSEAGLQHEILRR VQELLDAARIQPELKPPMGEVVTPT APQEPPESVRPSAPPAELEVQASEC VVCLEREAQMIFLNCGHVCCCQQCC QPLRTCPLCRQDIAQRLRIYHSSTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
